OLIG2
Summary: This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| oligodendrocyte transcription factor 2 | MIM:606386 | Ensembl:ENSG00000205927 | HGNC:HGNC:9398 | PA31919 | 21q22.11 |
GO terms in OLIG2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0071837 | HMG box domain binding |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005737 | cytoplasm |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0021522 | spinal cord motor neuron differentiation |
| BP | IEA | GO:0021530 | spinal cord oligodendrocyte cell fate specification |
| BP | IEA | GO:0021794 | thalamus development |
| BP | IEA | GO:0042552 | myelination |
| BP | IEA | GO:0045665 | negative regulation of neuron differentiation |
| BP | IEA | GO:0048663 | neuron fate commitment |
| BP | IEA | GO:0048714 | positive regulation of oligodendrocyte differentiation |
Gene expression in normal tissue: OLIG2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD221 | Tamoxifen | 1 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD144 | NSC95397 | 8 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD420 | Leucascandrolide A | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in OLIG2
CLASSFICATION
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