OLIG2

Summary: This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameoligodendrocyte transcription factor 2
OMIM IDMIM:606386
Ensembl IDEnsembl:ENSG00000205927
HGNC IDHGNC:HGNC:9398
PHARMGKB IDPA31919
Map Location21q22.11

GO terms in OLIG2


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IEA GO:0003677 DNA binding
MF IEA GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
MF IEA GO:0042803 protein homodimerization activity
Showing 1 to 6 of 18 rows rows per page

Gene expression in normal tissue: OLIG2

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 28undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 9LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 42BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 4

Gene-drug pathway distribution

undefined22Protein stability and degradation1PI3K/MTOR signaling1Biosynthesis of secondary metabolites1Drug metabolism - cytochrome P4501

Pathways in OLIG2


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP2064 Neural Crest Differentiation
Showing 1 to 1 of 1 rows

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD705 Nakiterpiosin 3
iGMDRD221 Tamoxifen 1
iGMDRD192 CIL56 3
iGMDRD782 DC-45-A2 3
Showing 1 to 4 of 26 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in OLIG2

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.