XPA


Summary: This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
XPA, DNA damage recognition and repair factorMIM:611153Ensembl:ENSG00000136936HGNC:HGNC:12814PA3689q22.33

Gene Categories:

DNA REPAIR

GO terms in XPA


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0000110nucleotide-excision repair factor 1 complex
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005662DNA replication factor A complex
CCIEAGO:0005737cytoplasm
CCIDAGO:0045171intercellular bridge
BPIBAGO:0000715nucleotide-excision repair, DNA damage recognition
BPIDAGO:0006281DNA repair
BPIMPGO:0006281DNA repair
BPTASGO:0006283transcription-coupled nucleotide-excision repair
BPIBAGO:0006284base-excision repair
BPTASGO:0006293nucleotide-excision repair, preincision complex stabilization
BPTASGO:0006294nucleotide-excision repair, preincision complex assembly
BPTASGO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion
BPIEAGO:0006979response to oxidative stress
BPIEAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0009636response to toxic substance
BPIDAGO:0009650UV protection
BPIMPGO:0009650UV protection
BPIEAGO:0010996response to auditory stimulus
BPIBAGO:0033683nucleotide-excision repair, DNA incision
BPIMPGO:0033683nucleotide-excision repair, DNA incision
BPTASGO:0033683nucleotide-excision repair, DNA incision
BPIMPGO:0034504protein localization to nucleus
BPIEAGO:0035264multicellular organism growth
BPTASGO:0070911global genome nucleotide-excision repair
BPIBAGO:0070914UV-damage excision repair
BPIBAGO:1901255nucleotide-excision repair involved in interstrand cross-link repair
MFIBAGO:0003684damaged DNA binding
MFIDAGO:0003684damaged DNA binding
MFIPIGO:0005515protein binding
MFIPIGO:0019904protein domain specific binding
MFIPIGO:0042803protein homodimerization activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: XPA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in XPA


DatabasePathway IDPathway Des.
smpdbSMP00478Nucleotide Excision Repair
kegghsa03420Nucleotide excision repair - Homo sapiens (human)
reactomeR-HSA-5696395Formation of Incision Complex in GG-NER
reactomeR-HSA-5696398Nucleotide Excision Repair
reactomeR-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)
reactomeR-HSA-5696400Dual Incision in GG-NER
reactomeR-HSA-6781823Formation of TC-NER Pre-Incision Complex
reactomeR-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)
reactomeR-HSA-6782135Dual incision in TC-NER
reactomeR-HSA-73894DNA Repair

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD599Salermide6
iGMDRD5Tyrphostin AG 14783
iGMDRD330BRD41321
iGMDRD221Tamoxifen3
iGMDRD2PK-111953
iGMDRD85Ursolic acid3
iGMDRD264Bryostatin 11
iGMDRD375GW-4058333

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in XPA

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