ACKR3

Summary: This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameatypical chemokine receptor 3
OMIM IDMIM:610376
Ensembl IDEnsembl:ENSG00000144476
HGNC IDHGNC:HGNC:23692
PHARMGKB IDPA162383053
Map Location2q37.3

GO terms in ACKR3


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0005634 nucleus
CC IDA GO:0005768 endosome
CC IEA GO:0005769 early endosome
CC IDA GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
CC IDA GO:0005905 clathrin-coated pit
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Gene expression in normal tissue: ACKR3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined18DNA replication1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Apoptosis regulation1Drug metabolism - cytochrome P4501Genome integrity1Chromatin histone acetylation1

Pathways in ACKR3


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Database
Pathway ID
Pathway Des.
wikipathways WP2880 Glucocorticoid Receptor Pathway
wikipathways WP2882 Nuclear Receptors Meta-Pathway
wikipathways WP289 Myometrial Relaxation and Contraction Pathways
wikipathways WP3888 VEGFA-VEGFR2 Signaling Pathway
wikipathways WP455 GPCRs, Class A Rhodopsin-like
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD132 (-)-gallocatechin-3-O-gallate 4
iGMDRD85 Ursolic acid 1
iGMDRD446 LY 2183240 1
iGMDRD499 PDMP 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACKR3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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