ACKR3
Summary: This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| atypical chemokine receptor 3 | MIM:610376 | Ensembl:ENSG00000144476 | HGNC:HGNC:23692 | PA162383053 | 2q37.3 |
GO terms in ACKR3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0005768 | endosome |
| CC | IEA | GO:0005769 | early endosome |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005905 | clathrin-coated pit |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IEA | GO:0055037 | recycling endosome |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001570 | vasculogenesis |
| BP | IBA | GO:0006935 | chemotaxis |
| BP | IEA | GO:0006935 | chemotaxis |
| BP | IBA | GO:0006955 | immune response |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | IEA | GO:0016032 | viral process |
| BP | IBA | GO:0019722 | calcium-mediated signaling |
| BP | IMP | GO:0031623 | receptor internalization |
| BP | IBA | GO:0060326 | cell chemotaxis |
| BP | IMP | GO:0070098 | chemokine-mediated signaling pathway |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IEA | GO:1905322 | positive regulation of mesenchymal stem cell migration |
| MF | IMP | GO:0005044 | scavenger receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0015026 | coreceptor activity |
| MF | IBA | GO:0016493 | C-C chemokine receptor activity |
| MF | IMP | GO:0016494 | C-X-C chemokine receptor activity |
| MF | IBA | GO:0019956 | chemokine binding |
| MF | IBA | GO:0019957 | C-C chemokine binding |
| MF | IMP | GO:0019958 | C-X-C chemokine binding |
Gene expression in normal tissue: ACKR3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ACKR3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-380108 | Chemokine receptors bind chemokines |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD499 | PDMP | 6 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD150 | RITA | 6 |
| iGMDRD307 | Manumycin A | 6 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD772 | BRD4770 | 6 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD82 | Quiflapon | 6 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD202 | Curcumin | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ACKR3
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.