MAP3K3


Summary: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase kinase kinase 3MIM:602539Ensembl:ENSG00000198909HGNC:HGNC:6855PA3059917q23.3

GO terms in MAP3K3


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIEAGO:0004709MAP kinase kinase kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0046872metal ion binding
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
BPTASGO:0000165MAPK cascade
BPIEAGO:0000186activation of MAPKK activity
BPIEAGO:0001568blood vessel development
BPIBAGO:0007346regulation of mitotic cell cycle
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIBAGO:0032147activation of protein kinase activity
BPIDAGO:0035556intracellular signal transduction
BPIEPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0046777protein autophosphorylation
BPTASGO:0070498interleukin-1-mediated signaling pathway
BPIMPGO:0071864positive regulation of cell proliferation in bone marrow
BPIGIGO:0090050positive regulation of cell migration involved in sprouting angiogenesis
BPIEAGO:1900745positive regulation of p38MAPK cascade
BPIMPGO:2000773negative regulation of cellular senescence

Gene expression in normal tissue: MAP3K3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP3K3


DatabasePathway IDPathway Des.
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP262EBV LMP1 signaling
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP422MAPK Cascade
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
netpathPathway_EGFR1EGFR1
netpathPathway_TNFalphaTNFalpha
pidil1pathwayIL1-mediated signaling events
pidp38_mkk3_6pathwayp38 MAPK signaling pathway
pidp38alphabetapathwayRegulation of p38-alpha and p38-beta
pidtnfpathwayTNF receptor signaling pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
biocartamapkpathwaymapkinase signaling pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-9020702Interleukin-1 signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD221Tamoxifen3
iGMDRD546BMS-7548073
iGMDRD483SCH-5290743
iGMDRD77Itraconazole2
iGMDRD474Avrainvillamide3
iGMDRD505Pevonedistat3
iGMDRD280CYTOCHALASIN B3
iGMDRD883CIL55A3
iGMDRD499PDMP3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K3

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