MAP3K3
Summary: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase 3 | MIM:602539 | Ensembl:ENSG00000198909 | HGNC:HGNC:6855 | PA30599 | 17q23.3 |
GO terms in MAP3K3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000186 | activation of MAPKK activity |
| BP | IEA | GO:0001568 | blood vessel development |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IMP | GO:0071864 | positive regulation of cell proliferation in bone marrow |
| BP | IGI | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| BP | IEA | GO:1900745 | positive regulation of p38MAPK cascade |
| BP | IMP | GO:2000773 | negative regulation of cellular senescence |
Gene expression in normal tissue: MAP3K3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP3K3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP262 | EBV LMP1 signaling |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP422 | MAPK Cascade |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TNFalpha | TNFalpha |
| pid | il1pathway | IL1-mediated signaling events |
| pid | p38_mkk3_6pathway | p38 MAPK signaling pathway |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| pid | tnfpathway | TNF receptor signaling pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| biocarta | mapkpathway | mapkinase signaling pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD499 | PDMP | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP3K3
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