PIK3C2G
Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609001 Ensembl IDEnsembl:ENSG00000139144 HGNC IDHGNC:HGNC:8973 PHARMGKB IDPA33306 Map Location12p12.3 | |||||
GO terms in PIK3C2G
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | NAS | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | NAS | GO:0016307 | phosphatidylinositol phosphate kinase activity |
| MF | IBA | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| MF | IEA | GO:0035091 | phosphatidylinositol binding |
Gene expression in normal tissue: PIK3C2G
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIK3C2G
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| humancyc | PWY-6352 | 3-phosphoinositide biosynthesis |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIK3C2G
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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