PIK3C2G
Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma | MIM:609001 | Ensembl:ENSG00000139144 | HGNC:HGNC:8973 | PA33306 | 12p12.3 |
GO terms in PIK3C2G
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | NAS | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | NAS | GO:0016307 | phosphatidylinositol phosphate kinase activity |
| MF | IBA | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| MF | IEA | GO:0035091 | phosphatidylinositol binding |
| MF | IBA | GO:0052742 | phosphatidylinositol kinase activity |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005942 | phosphatidylinositol 3-kinase complex |
| CC | IBA | GO:0016020 | membrane |
| BP | IEA | GO:0006935 | chemotaxis |
| BP | IBA | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | IBA | GO:0016477 | cell migration |
| BP | IBA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | IMP | GO:0039694 | viral RNA genome replication |
| BP | IBA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IBA | GO:0048015 | phosphatidylinositol-mediated signaling |
Gene expression in normal tissue: PIK3C2G
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIK3C2G
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| humancyc | PWY-6352 | 3-phosphoinositide biosynthesis |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| biocarta | ccr3pathway | ccr3 signaling in eosinophils |
| biocarta | cxcr4pathway | cxcr4 signaling pathway |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-1660499 | Synthesis of PIPs at the plasma membrane |
| reactome | R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD871 | BRD6368 | 8 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD227 | Fatostatin A | 3 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD499 | PDMP | 6 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD424 | Tamatinib | 5 |
| iGMDRD523 | Cyanoquinoline, 11 | 5 |
| iGMDRD405 | PIK-75 | 5 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD885 | Compound 110 | 4 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD359 | OSW-1 | 3 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD483 | SCH-529074 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIK3C2G
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