PIK3C2G


Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gammaMIM:609001Ensembl:ENSG00000139144HGNC:HGNC:8973PA3330612p12.3

GO terms in PIK3C2G


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005524ATP binding
MFIBAGO:00163031-phosphatidylinositol-3-kinase activity
MFNASGO:00163031-phosphatidylinositol-3-kinase activity
MFNASGO:0016307phosphatidylinositol phosphate kinase activity
MFIBAGO:00350051-phosphatidylinositol-4-phosphate 3-kinase activity
MFIEAGO:0035091phosphatidylinositol binding
MFIBAGO:0052742phosphatidylinositol kinase activity
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCIBAGO:0005942phosphatidylinositol 3-kinase complex
CCIBAGO:0016020membrane
BPIEAGO:0006935chemotaxis
BPIBAGO:0014065phosphatidylinositol 3-kinase signaling
BPIBAGO:0016477cell migration
BPIBAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIMPGO:0039694viral RNA genome replication
BPIBAGO:0046854phosphatidylinositol phosphorylation
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPIBAGO:0048015phosphatidylinositol-mediated signaling

Gene expression in normal tissue: PIK3C2G

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIK3C2G


DatabasePathway IDPathway Des.
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP710DNA Damage Response (only ATM dependent)
humancycPWY-63523-phosphoinositide biosynthesis
humancycPWY-6371superpathway of inositol phosphate compounds
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
biocartaccr3pathwayccr3 signaling in eosinophils
biocartacxcr4pathwaycxcr4 signaling pathway
biocartaedg1pathwayphospholipids as signalling intermediaries
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483255PI Metabolism
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-1660499Synthesis of PIPs at the plasma membrane
reactomeR-HSA-1660514Synthesis of PIPs at the Golgi membrane
reactomeR-HSA-556833Metabolism of lipids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD871BRD63688
iGMDRD300Tozasertib2
iGMDRD886Compound 1541A2
iGMDRD227Fatostatin A3
iGMDRD221Tamoxifen2
iGMDRD105Triptolide2
iGMDRD289Parthenolide2
iGMDRD434BMS-5369243
iGMDRD481Dactolisib1
iGMDRD85Ursolic acid1
iGMDRD499PDMP6
iGMDRD698Neratinib2
iGMDRD219Bax channel blocker3
iGMDRD84Lovastatin acid3
iGMDRD584VER 1550082
iGMDRD150RITA2
iGMDRD424Tamatinib5
iGMDRD523Cyanoquinoline, 115
iGMDRD405PIK-755
iGMDRD100Zebularine2
iGMDRD188Piperlongumine4
iGMDRD399Selumetinib3
iGMDRD887Compound 23 citrate3
iGMDRD577BIX012944
iGMDRD562Navitoclax3
iGMDRD780PP-303
iGMDRD64Parbendazole3
iGMDRD23Gossypol5
iGMDRD138PX 122
iGMDRD782DC-45-A23
iGMDRD885Compound 1104
iGMDRD318PAC-14
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD61Kinetin riboside3
iGMDRD193Fqi13
iGMDRD152179324-69-71
iGMDRD394BX-7954
iGMDRD679Bistramide A1
iGMDRD280CYTOCHALASIN B5
iGMDRD359OSW-13
iGMDRD126Tipifarnib7
iGMDRD1008SR-II-138A2
iGMDRD670ML 2101
iGMDRD483SCH-5290742

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIK3C2G

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