TSHR


Summary: The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
thyroid stimulating hormone receptorMIM:603372Ensembl:ENSG00000165409HGNC:HGNC:12373PA3704214q31.1

GO terms in TSHR


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004996thyroid-stimulating hormone receptor activity
MFIMPGO:0004996thyroid-stimulating hormone receptor activity
MFIPIGO:0005515protein binding
MFIBAGO:0008528G-protein coupled peptide receptor activity
MFIMPGO:0038023signaling receptor activity
MFIDAGO:0044877protein-containing complex binding
CCIEAGO:0005622intracellular
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCISSGO:0009986cell surface
CCIDAGO:0016323basolateral plasma membrane
CCIDAGO:0043235receptor complex
BPIMPGO:0007166cell surface receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
BPIBAGO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway
BPIBAGO:0007190activation of adenylate cyclase activity
BPTASGO:0007267cell-cell signaling
BPTASGO:0008284positive regulation of cell proliferation
BPIBAGO:0009755hormone-mediated signaling pathway
BPIMPGO:0038194thyroid-stimulating hormone signaling pathway
BPIMPGO:0045762positive regulation of adenylate cyclase activity
BPIMPGO:1904588cellular response to glycoprotein
BPIMPGO:1905229cellular response to thyrotropin-releasing hormone

Gene expression in normal tissue: TSHR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TSHR


DatabasePathway IDPathway Des.
pidarf6_pathwayArf6 signaling events
pidarf6_traffickingpathwayArf6 trafficking events
netpathPathway_TSHTSH
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa04923Regulation of lipolysis in adipocytes - Homo sapiens (human)
kegghsa05320Autoimmune thyroid disease - Homo sapiens (human)
wikipathwaysWP1981Thyroxine (Thyroid Hormone) Production
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP24Peptide GPCRs
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375281Hormone ligand-binding receptors
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418555G alpha (s) signalling events
reactomeR-HSA-500792GPCR ligand binding

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD267Oligomycin A2
iGMDRD882CIL412
iGMDRD872BRD71377
iGMDRD414MST-3122
iGMDRD505Pevonedistat4
iGMDRD300Tozasertib3
iGMDRD886Compound 1541A2
iGMDRD82Quiflapon3
iGMDRD84Lovastatin acid2
iGMDRD148Pifithrin-mu3
iGMDRD512nutlin 31
iGMDRD424Tamatinib8
iGMDRD299ICL 6701
iGMDRD701NVP-AUY9223
iGMDRD85Ursolic acid4
iGMDRD351GW843682X2
iGMDRD499PDMP2
iGMDRD177Teniposide4
iGMDRD211(1S,3R)-RSL32
iGMDRD270Ciclosporin3
iGMDRD480KU00606482
iGMDRD255SB2250023
iGMDRD8024-methylfasudil2
iGMDRD782DC-45-A25
iGMDRD870BRD636102
iGMDRD30917AAG1
iGMDRD318PAC-16
iGMDRD562Navitoclax7
iGMDRD268Cerulenin1
iGMDRD1008SR-II-138A1
iGMDRD772BRD47703
iGMDRD599Salermide3
iGMDRD144NSC953979
iGMDRD446LY 21832401
iGMDRD297Austocystin D1
iGMDRD375GW-4058336
iGMDRD202Curcumin5
iGMDRD158NSC1415405
iGMDRD103SN-382
iGMDRD5Tyrphostin AG 14787
iGMDRD221Tamoxifen4
iGMDRD213SMR0000686502
iGMDRD77Itraconazole8
iGMDRD871BRD63686
iGMDRD367Ro 28-16755
iGMDRD330BRD41321
iGMDRD522ML-0301
iGMDRD560MK-22061
iGMDRD583LDN 1931892
iGMDRD523Cyanoquinoline, 116
iGMDRD219Bax channel blocker3
iGMDRD314Tanespimycin3
iGMDRD698Neratinib3
iGMDRD123Isoevodiamine6
iGMDRD474Avrainvillamide6
iGMDRD513BML-2591
iGMDRD207Capsaicin3
iGMDRD226ML0063
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD780PP-301
iGMDRD888Compound 443
iGMDRD369TGX-1154
iGMDRD524ISX-94
iGMDRD356PNU-746543
iGMDRD23Gossypol3
iGMDRD126Tipifarnib3
iGMDRD76Simvastatin3
iGMDRD889Compound 7d-cis5
iGMDRD670ML 2102
iGMDRD546BMS-7548073
iGMDRD427ABT7373
iGMDRD483SCH-5290743
iGMDRD61Kinetin riboside6
iGMDRD2PK-111951
iGMDRD394BX-7951

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TSHR

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