TSHR
Summary: The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603372 Ensembl IDEnsembl:ENSG00000165409 HGNC IDHGNC:HGNC:12373 PHARMGKB IDPA37042 Map Location14q31.1 | |||||
GO terms in TSHR
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004996 | thyroid-stimulating hormone receptor activity |
| MF | IMP | GO:0004996 | thyroid-stimulating hormone receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008528 | G-protein coupled peptide receptor activity |
| MF | IMP | GO:0038023 | signaling receptor activity |
| MF | IDA | GO:0044877 | protein-containing complex binding |
Gene expression in normal tissue: TSHR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TSHR
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | arf6_pathway | Arf6 signaling events |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| netpath | Pathway_TSH | TSH |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TSHR
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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