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SIX4

Summary: This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells. [provided by RefSeq, May 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
SIX homeobox 4	MIM:606342	Ensembl:ENSG00000100625	HGNC:HGNC:10890	PA35790	14q23.1

GO terms in SIX4

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0006366	transcription by RNA polymerase II
BP	ISS	GO:0007519	skeletal muscle tissue development
BP	IEA	GO:0008582	regulation of synaptic growth at neuromuscular junction
BP	ISS	GO:0008584	male gonad development
BP	TAS	GO:0009653	anatomical structure morphogenesis
BP	ISS	GO:0030238	male sex determination
BP	ISS	GO:0030910	olfactory placode formation
BP	IEA	GO:0032880	regulation of protein localization
BP	ISS	GO:0034504	protein localization to nucleus
BP	IEA	GO:0042472	inner ear morphogenesis
BP	ISS	GO:0043066	negative regulation of apoptotic process
BP	ISS	GO:0043524	negative regulation of neuron apoptotic process
BP	ISS	GO:0043586	tongue development
BP	ISS	GO:0045214	sarcomere organization
BP	IBA	GO:0045892	negative regulation of transcription, DNA-templated
BP	ISS	GO:0045892	negative regulation of transcription, DNA-templated
BP	ISS	GO:0045893	positive regulation of transcription, DNA-templated
BP	IEA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	ISS	GO:0046661	male sex differentiation
BP	IEA	GO:0048538	thymus development
BP	ISS	GO:0048699	generation of neurons
BP	IEA	GO:0048701	embryonic cranial skeleton morphogenesis
BP	IBA	GO:0048856	anatomical structure development
BP	ISS	GO:0050678	regulation of epithelial cell proliferation
BP	IEA	GO:0051451	myoblast migration
BP	ISS	GO:0060037	pharyngeal system development
BP	ISS	GO:0061055	myotome development
BP	ISS	GO:0061197	fungiform papilla morphogenesis
BP	ISS	GO:0061551	trigeminal ganglion development
BP	ISS	GO:0072075	metanephric mesenchyme development
BP	ISS	GO:0072095	regulation of branch elongation involved in ureteric bud branching
BP	ISS	GO:0072107	positive regulation of ureteric bud formation
BP	ISS	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
BP	ISS	GO:0098528	skeletal muscle fiber differentiation
BP	ISS	GO:1902725	negative regulation of satellite cell differentiation
CC	IBA	GO:0005634	nucleus
CC	ISS	GO:0005634	nucleus
CC	IBA	GO:0005667	transcription factor complex
CC	ISS	GO:0005737	cytoplasm
MF	IBA	GO:0000976	transcription regulatory region sequence-specific DNA binding
MF	IEA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IBA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IEA	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IBA	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding

Gene expression in normal tissue: SIX4

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SIX4

Database	Pathway ID	Pathway Des.
kegg	hsa05202	Transcriptional misregulation in cancer - Homo sapiens (human)
wikipathways	WP3595	mir-124 predicted interactions with cell cycle and differentiation

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD887	Compound 23 citrate	2
iGMDRD74	Idarubicin	3
iGMDRD188	Piperlongumine	4
iGMDRD780	PP-30	6
iGMDRD398	Sepantronium	3
iGMDRD577	BIX01294	2
iGMDRD369	TGX-115	2
iGMDRD444	Tivantinib	2
iGMDRD524	ISX-9	1
iGMDRD451	Serdemetan	3
iGMDRD598	QS-11	3
iGMDRD356	PNU-74654	2
iGMDRD23	Gossypol	3
iGMDRD474	Avrainvillamide	2
iGMDRD513	BML-259	2
iGMDRD255	SB225002	2
iGMDRD802	4-methylfasudil	2
iGMDRD187	BRD9876	3
iGMDRD801	2,4-dideoxy-DC-45-A2	2
iGMDRD201	SKI II	2
iGMDRD446	LY 2183240	4
iGMDRD163	all trans Retinoic Acid	2
iGMDRD316	N9-Isopropyl-olomoucine	2
iGMDRD280	CYTOCHALASIN B	5
iGMDRD466	Chaetocin	3
iGMDRD375	GW-405833	2
iGMDRD210	AC55649	1
iGMDRD554	CHEMBL1434137	1
iGMDRD126	Tipifarnib	6
iGMDRD1008	SR-II-138A	2
iGMDRD387	CHIR-99021	3
iGMDRD889	Compound 7d-cis	2
iGMDRD427	ABT737	3
iGMDRD546	BMS-754807	2
iGMDRD483	SCH-529074	3
iGMDRD882	CIL41	3
iGMDRD286	Nsc 632839	2
iGMDRD269	Purmorphamine	1
iGMDRD329	Merck60	2
iGMDRD137	Indisulam	9
iGMDRD158	NSC141540	2
iGMDRD202	Curcumin	2
iGMDRD278	TTNPB	2
iGMDRD5	Tyrphostin AG 1478	3
iGMDRD434	BMS-536924	3
iGMDRD221	Tamoxifen	3
iGMDRD6	AM-580	3
iGMDRD351	GW843682X	1
iGMDRD123	Isoevodiamine	2
iGMDRD84	Lovastatin acid	2
iGMDRD584	VER 155008	2
iGMDRD512	nutlin 3	3
iGMDRD607	Ubistatin B	3
iGMDRD345	Compound 10b [PMID: 11504634]	5
iGMDRD424	Tamatinib	3
iGMDRD150	RITA	3
iGMDRD405	PIK-75	2
iGMDRD701	NVP-AUY922	5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SIX4

SITE

DATATYPES

CLASSFICATION

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