XIAP


Summary: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
X-linked inhibitor of apoptosisMIM:300079Ensembl:ENSG00000101966HGNC:HGNC:592PA25361Xq25

GO terms in XIAP


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
BPIEAGO:0006915apoptotic process
BPIEPGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0016055Wnt signaling pathway
BPIEAGO:0016567protein ubiquitination
BPTASGO:0030510regulation of BMP signaling pathway
BPIDAGO:0031398positive regulation of protein ubiquitination
BPTASGO:0042127regulation of cell proliferation
BPIMPGO:0043066negative regulation of apoptotic process
BPIDAGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0045088regulation of innate immune response
BPTASGO:0050727regulation of inflammatory response
BPTASGO:0055070copper ion homeostasis
BPTASGO:0070424regulation of nucleotide-binding oligomerization domain containing signaling pathway
BPIBAGO:0090263positive regulation of canonical Wnt signaling pathway
BPIMPGO:0090263positive regulation of canonical Wnt signaling pathway
BPIBAGO:0090307mitotic spindle assembly
BPIDAGO:1902530positive regulation of protein linear polyubiquitination
BPIBAGO:1990001inhibition of cysteine-type endopeptidase activity involved in apoptotic process
MFIDAGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFIBAGO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process
MFIDAGO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process
MFIEAGO:0046872metal ion binding
MFEXPGO:0061630ubiquitin protein ligase activity
MFIBAGO:0061630ubiquitin protein ligase activity
MFTASGO:0061630ubiquitin protein ligase activity

Gene expression in normal tissue: XIAP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in XIAP


DatabasePathway IDPathway Des.
wikipathwaysWP1433Nucleotide-binding Oligomerization Domain (NOD) pathway
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP254Apoptosis
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3286Copper homeostasis
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
pidbmppathwayBMP receptor signaling
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidp75ntrpathwayp75(NTR)-mediated signaling
pidtgfbrpathwayTGF-beta receptor signaling
netpathPathway_TNFalphaTNFalpha
pharmgkbPA165374494Busulfan Pathway, Pharmacodynamics
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
biocartacaspasepathwaycaspase cascade in apoptosis
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111463SMAC binds to IAPs
reactomeR-HSA-111463SMAC binds to IAPs
reactomeR-HSA-111464SMAC-mediated dissociation of IAP:caspase complexes
reactomeR-HSA-111464SMAC-mediated dissociation of IAP:caspase complexes
reactomeR-HSA-111469SMAC-mediated apoptotic response
reactomeR-HSA-111469SMAC-mediated apoptotic response
reactomeR-HSA-111471Apoptotic factor-mediated response
reactomeR-HSA-111471Apoptotic factor-mediated response
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-3769402Deactivation of the beta-catenin transactivating complex
reactomeR-HSA-5213460RIPK1-mediated regulated necrosis
reactomeR-HSA-5218859Regulated Necrosis
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5357905Regulation of TNFR1 signaling
reactomeR-HSA-5357956TNFR1-induced NFkappaB signaling pathway
reactomeR-HSA-5675482Regulation of necroptotic cell death
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-75893TNF signaling
reactomeR-HSA-8948747Regulation of PTEN localization
reactomeR-HSA-8948751Regulation of PTEN stability and activity
reactomeR-HSA-9006925Intracellular signaling by second messengers

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD280CYTOCHALASIN B5
iGMDRD193Fqi12
iGMDRD446LY 21832401
iGMDRD427ABT7376
iGMDRD772BRD47706
iGMDRD1008SR-II-138A2
iGMDRD889Compound 7d-cis4
iGMDRD599Salermide2
iGMDRD554CHEMBL14341372
iGMDRD126Tipifarnib2
iGMDRD524ISX-95
iGMDRD451Serdemetan2
iGMDRD23Gossypol2
iGMDRD64Parbendazole3
iGMDRD562Navitoclax3
iGMDRD577BIX012946
iGMDRD506Fedratinib3
iGMDRD887Compound 23 citrate2
iGMDRD399Selumetinib2
iGMDRD74Idarubicin6
iGMDRD100Zebularine3
iGMDRD188Piperlongumine2
iGMDRD187BRD98763
iGMDRD52Rotenone3
iGMDRD318PAC-12
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD171Pemetrexed5
iGMDRD8024-methylfasudil3
iGMDRD138PX 122
iGMDRD513BML-2592
iGMDRD270Ciclosporin3
iGMDRD945ML2142
iGMDRD132(-)-gallocatechin-3-O-gallate5
iGMDRD177Teniposide2
iGMDRD123Isoevodiamine2
iGMDRD901ELCPK3
iGMDRD499PDMP5
iGMDRD85Ursolic acid4
iGMDRD116CD4372
iGMDRD532Olaparib3
iGMDRD148Pifithrin-mu3
iGMDRD307Manumycin A4
iGMDRD322FK 8663
iGMDRD82Quiflapon6
iGMDRD246NPC263
iGMDRD505Pevonedistat3
iGMDRD662JQ-12
iGMDRD872BRD71372
iGMDRD871BRD63685
iGMDRD415LE-1353
iGMDRD221Tamoxifen5
iGMDRD105Triptolide3
iGMDRD289Parthenolide2
iGMDRD5Tyrphostin AG 14782
iGMDRD121GMX17782
iGMDRD158NSC1415408
iGMDRD202Curcumin5
iGMDRD271Brefeldin A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in XIAP

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