XIAP
Summary: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| X-linked inhibitor of apoptosis | MIM:300079 | Ensembl:ENSG00000101966 | HGNC:HGNC:592 | PA25361 | Xq25 |
GO terms in XIAP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | TAS | GO:0030510 | regulation of BMP signaling pathway |
| BP | IDA | GO:0031398 | positive regulation of protein ubiquitination |
| BP | TAS | GO:0042127 | regulation of cell proliferation |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0045088 | regulation of innate immune response |
| BP | TAS | GO:0050727 | regulation of inflammatory response |
| BP | TAS | GO:0055070 | copper ion homeostasis |
| BP | TAS | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway |
| BP | IBA | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IBA | GO:0090307 | mitotic spindle assembly |
| BP | IDA | GO:1902530 | positive regulation of protein linear polyubiquitination |
| BP | IBA | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| MF | IDA | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | EXP | GO:0061630 | ubiquitin protein ligase activity |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
| MF | TAS | GO:0061630 | ubiquitin protein ligase activity |
Gene expression in normal tissue: XIAP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in XIAP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1433 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3286 | Copper homeostasis |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| pid | bmppathway | BMP receptor signaling |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | tgfbrpathway | TGF-beta receptor signaling |
| netpath | Pathway_TNFalpha | TNFalpha |
| pharmgkb | PA165374494 | Busulfan Pathway, Pharmacodynamics |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111463 | SMAC binds to IAPs |
| reactome | R-HSA-111463 | SMAC binds to IAPs |
| reactome | R-HSA-111464 | SMAC-mediated dissociation of IAP:caspase complexes |
| reactome | R-HSA-111464 | SMAC-mediated dissociation of IAP:caspase complexes |
| reactome | R-HSA-111469 | SMAC-mediated apoptotic response |
| reactome | R-HSA-111469 | SMAC-mediated apoptotic response |
| reactome | R-HSA-111471 | Apoptotic factor-mediated response |
| reactome | R-HSA-111471 | Apoptotic factor-mediated response |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex |
| reactome | R-HSA-5213460 | RIPK1-mediated regulated necrosis |
| reactome | R-HSA-5218859 | Regulated Necrosis |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5357905 | Regulation of TNFR1 signaling |
| reactome | R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway |
| reactome | R-HSA-5675482 | Regulation of necroptotic cell death |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75893 | TNF signaling |
| reactome | R-HSA-8948747 | Regulation of PTEN localization |
| reactome | R-HSA-8948751 | Regulation of PTEN stability and activity |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD772 | BRD4770 | 6 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD889 | Compound 7d-cis | 4 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD524 | ISX-9 | 5 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD74 | Idarubicin | 6 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD171 | Pemetrexed | 5 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 5 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD499 | PDMP | 5 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD307 | Manumycin A | 4 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD82 | Quiflapon | 6 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD221 | Tamoxifen | 5 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD158 | NSC141540 | 8 |
| iGMDRD202 | Curcumin | 5 |
| iGMDRD271 | Brefeldin A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in XIAP
CLASSFICATION
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