TG
Summary: Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| thyroglobulin | MIM:188450 | Ensembl:ENSG00000042832 | HGNC:HGNC:11764 | PA36479 | 8q24.22 |
GO terms in TG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005179 | hormone activity |
| CC | NAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005615 | extracellular space |
| BP | NAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0015705 | iodide transport |
| BP | IEP | GO:0030878 | thyroid gland development |
| BP | IEA | GO:0031641 | regulation of myelination |
| BP | IEA | GO:0042403 | thyroid hormone metabolic process |
| BP | IEA | GO:0042446 | hormone biosynthetic process |
Gene expression in normal tissue: TG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1981 | Thyroxine (Thyroid Hormone) Production |
| smpdb | SMP00716 | Thyroid hormone synthesis |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa05320 | Autoimmune thyroid disease - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD271 | Brefeldin A | 4 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD221 | Tamoxifen | 1 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD367 | Ro 28-1675 | 5 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD522 | ML-030 | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD405 | PIK-75 | 4 |
| iGMDRD85 | Ursolic acid | 5 |
| iGMDRD341 | Triacsin c | 9 |
| iGMDRD57 | Chloropentafluorobenzene | 5 |
| iGMDRD314 | Tanespimycin | 4 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD480 | KU0060648 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD427 | ABT737 | 7 |
| iGMDRD494 | Neopeltolide | 5 |
| iGMDRD483 | SCH-529074 | 5 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TG
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