TG
Summary: Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namethyroglobulin OMIM IDMIM:188450 Ensembl IDEnsembl:ENSG00000042832 HGNC IDHGNC:HGNC:11764 PHARMGKB IDPA36479 Map Location8q24.22 | |||||
GO terms in TG
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005179 | hormone activity |
| CC | NAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005615 | extracellular space |
| BP | NAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0015705 | iodide transport |
Gene expression in normal tissue: TG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TG
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1981 | Thyroxine (Thyroid Hormone) Production |
| smpdb | SMP00716 | Thyroid hormone synthesis |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa05320 | Autoimmune thyroid disease - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TG
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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