TG


Summary: Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
thyroglobulinMIM:188450Ensembl:ENSG00000042832HGNC:HGNC:11764PA364798q24.22

GO terms in TG


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005179hormone activity
CCNASGO:0005576extracellular region
CCIEAGO:0005615extracellular space
BPNASGO:0007165signal transduction
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0015705iodide transport
BPIEPGO:0030878thyroid gland development
BPIEAGO:0031641regulation of myelination
BPIEAGO:0042403thyroid hormone metabolic process
BPIEAGO:0042446hormone biosynthetic process

Gene expression in normal tissue: TG

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TG


DatabasePathway IDPathway Des.
wikipathwaysWP1981Thyroxine (Thyroid Hormone) Production
smpdbSMP00716Thyroid hormone synthesis
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa05320Autoimmune thyroid disease - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD271Brefeldin A4
iGMDRD137Indisulam2
iGMDRD434BMS-5369243
iGMDRD289Parthenolide2
iGMDRD221Tamoxifen1
iGMDRD77Itraconazole3
iGMDRD267Oligomycin A2
iGMDRD68Paclitaxel1
iGMDRD872BRD71373
iGMDRD367Ro 28-16755
iGMDRD871BRD63682
iGMDRD662JQ-12
iGMDRD329Merck601
iGMDRD300Tozasertib3
iGMDRD886Compound 1541A3
iGMDRD82Quiflapon3
iGMDRD522ML-0302
iGMDRD150RITA2
iGMDRD405PIK-754
iGMDRD85Ursolic acid5
iGMDRD341Triacsin c9
iGMDRD57Chloropentafluorobenzene5
iGMDRD314Tanespimycin4
iGMDRD123Isoevodiamine2
iGMDRD901ELCPK3
iGMDRD154NSC237662
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD138PX 121
iGMDRD270Ciclosporin2
iGMDRD480KU00606481
iGMDRD255SB2250023
iGMDRD8024-methylfasudil3
iGMDRD260FQI-23
iGMDRD52Rotenone1
iGMDRD187BRD98763
iGMDRD885Compound 1103
iGMDRD399Selumetinib3
iGMDRD74Idarubicin1
iGMDRD780PP-303
iGMDRD562Navitoclax6
iGMDRD577BIX012942
iGMDRD369TGX-1152
iGMDRD60Quinoclamine5
iGMDRD451Serdemetan1
iGMDRD151CHM-14
iGMDRD126Tipifarnib4
iGMDRD420Leucascandrolide A3
iGMDRD427ABT7377
iGMDRD494Neopeltolide5
iGMDRD483SCH-5290745
iGMDRD152179324-69-71
iGMDRD61Kinetin riboside1
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD466Chaetocin2
iGMDRD280CYTOCHALASIN B2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TG

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