SEARCH

HOME / SEARCH / ITGB4

ITGB4

Summary: Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
integrin subunit beta 4	MIM:147557	Ensembl:ENSG00000132470	HGNC:HGNC:6158	PA29957	17q25.1

Gene Categories:

DRUGGABLE GENOME CELL SURFACE

GO terms in ITGB4

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	IBA	GO:0005925	focal adhesion
CC	IBA	GO:0008305	integrin complex
CC	IEA	GO:0008305	integrin complex
CC	IBA	GO:0009986	cell surface
CC	IDA	GO:0009986	cell surface
CC	IDA	GO:0030054	cell junction
CC	IDA	GO:0030056	hemidesmosome
CC	IDA	GO:0031252	cell leading edge
CC	IDA	GO:0043235	receptor complex
CC	HDA	GO:0070062	extracellular exosome
BP	IMP	GO:0006914	autophagy
BP	NAS	GO:0007155	cell adhesion
BP	IBA	GO:0007160	cell-matrix adhesion
BP	IMP	GO:0007160	cell-matrix adhesion
BP	IBA	GO:0007229	integrin-mediated signaling pathway
BP	IEA	GO:0007229	integrin-mediated signaling pathway
BP	IDA	GO:0009611	response to wounding
BP	IBA	GO:0016477	cell migration
BP	TAS	GO:0030198	extracellular matrix organization
BP	IDA	GO:0031581	hemidesmosome assembly
BP	IMP	GO:0031581	hemidesmosome assembly
BP	TAS	GO:0031581	hemidesmosome assembly
BP	IBA	GO:0033627	cell adhesion mediated by integrin
BP	IMP	GO:0035878	nail development
BP	IMP	GO:0043588	skin development
BP	IEP	GO:0048333	mesodermal cell differentiation
BP	IMP	GO:0048565	digestive tract development
BP	IMP	GO:0048870	cell motility
BP	IMP	GO:0072001	renal system development
BP	IMP	GO:0097186	amelogenesis
MF	IPI	GO:0001664	G-protein coupled receptor binding
MF	IBA	GO:0005178	integrin binding
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0031994	insulin-like growth factor I binding
MF	IDA	GO:0038132	neuregulin binding

Gene expression in normal tissue: ITGB4

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITGB4

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1474290	Collagen formation
reactome	R-HSA-1500931	Cell-Cell communication
reactome	R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures
reactome	R-HSA-3000157	Laminin interactions
reactome	R-HSA-3000170	Syndecan interactions
reactome	R-HSA-3000171	Non-integrin membrane-ECM interactions
reactome	R-HSA-446107	Type I hemidesmosome assembly
reactome	R-HSA-446728	Cell junction organization
pid	a6b1_a6b4_integrin_pathway	a6b1 and a6b4 Integrin signaling
pid	fra_pathway	Validated transcriptional targets of AP1 family members Fra1 and Fra2
pid	integrin4_pathway	Alpha6 beta4 integrin-ligand interactions
pid	myc_represspathway	Validated targets of C-MYC transcriptional repression
pid	tap63pathway	Validated transcriptional targets of TAp63 isoforms
netpath	Pathway_Alpha6Beta4Integrin	Alpha6Beta4Integrin
netpath	Pathway_EGFR1	EGFR1
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa04510	Focal adhesion - Homo sapiens (human)
kegg	hsa04512	ECM-receptor interaction - Homo sapiens (human)
kegg	hsa04810	Regulation of actin cytoskeleton - Homo sapiens (human)
kegg	hsa05165	Human papillomavirus infection - Homo sapiens (human)
kegg	hsa05410	Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegg	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
kegg	hsa05414	Dilated cardiomyopathy (DCM) - Homo sapiens (human)
wikipathways	WP185	Integrin-mediated Cell Adhesion
wikipathways	WP2002	miR-targeted genes in epithelium - TarBase
wikipathways	WP2005	miR-targeted genes in muscle cell - TarBase
wikipathways	WP2118	Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathways	WP244	Alpha 6 Beta 4 signaling pathway
wikipathways	WP2572	Primary Focal Segmental Glomerulosclerosis FSGS
wikipathways	WP306	Focal Adhesion
wikipathways	WP366	TGF-beta Signaling Pathway
wikipathways	WP3872	Regulation of Apoptosis by Parathyroid Hormone-related Protein
wikipathways	WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways	WP4172	PI3K-Akt Signaling Pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD782	DC-45-A2	5
iGMDRD171	Pemetrexed	2
iGMDRD318	PAC-1	2
iGMDRD474	Avrainvillamide	6
iGMDRD802	4-methylfasudil	2
iGMDRD134	Sorafenib	1
iGMDRD131	Erlotinib	1
iGMDRD874	BRD8958	3
iGMDRD399	Selumetinib	1
iGMDRD577	BIX01294	2
iGMDRD888	Compound 44	2
iGMDRD398	Sepantronium	2
iGMDRD772	BRD4770	2
iGMDRD280	CYTOCHALASIN B	1
iGMDRD375	GW-405833	2
iGMDRD634	SCHEMBL2608041	2
iGMDRD152	179324-69-7	3
iGMDRD221	Tamoxifen	3
iGMDRD415	LE-135	2
iGMDRD77	Itraconazole	5
iGMDRD300	Tozasertib	5
iGMDRD505	Pevonedistat	2
iGMDRD353	PD0325901	2
iGMDRD322	FK 866	2
iGMDRD345	Compound 10b [PMID: 11504634]	4
iGMDRD701	NVP-AUY922	3
iGMDRD84	Lovastatin acid	2
iGMDRD307	Manumycin A	3
iGMDRD512	nutlin 3	2
iGMDRD177	Teniposide	2
iGMDRD123	Isoevodiamine	2
iGMDRD85	Ursolic acid	2
iGMDRD698	Neratinib	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGB4

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.