SIK2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| salt inducible kinase 2 | MIM:608973 | Ensembl:ENSG00000170145 | HGNC:HGNC:21680 | PA164725750 | 11q23.1 |
GO terms in SIK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0032007 | negative regulation of TOR signaling |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0042149 | cellular response to glucose starvation |
| BP | ISS | GO:0046626 | regulation of insulin receptor signaling pathway |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IBA | GO:0031588 | nucleotide-activated protein kinase complex |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
Gene expression in normal tissue: SIK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SIK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| pid | lkb1_pathway | LKB1 signaling events |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 5 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD424 | Tamatinib | 6 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD148 | Pifithrin-mu | 5 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD322 | FK 866 | 4 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD286 | Nsc 632839 | 7 |
| iGMDRD269 | Purmorphamine | 4 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD221 | Tamoxifen | 5 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD213 | SMR000068650 | 5 |
| iGMDRD481 | Dactolisib | 4 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD201 | SKI II | 5 |
| iGMDRD107 | Valdecoxib | 5 |
| iGMDRD2 | PK-11195 | 1 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD163 | all trans Retinoic Acid | 3 |
| iGMDRD670 | ML 210 | 5 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD433 | Lexibulin | 4 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD866 | BRD1812 | 5 |
| iGMDRD579 | PF750 | 5 |
| iGMDRD772 | BRD4770 | 5 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD690 | PRIMA-1MET | 7 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD356 | PNU-74654 | 5 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD730 | Kahalalide F | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD888 | Compound 44 | 7 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD255 | SB225002 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SIK2
CLASSFICATION
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