RHOH


Summary: The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ras homolog family member HMIM:602037Ensembl:ENSG00000168421HGNC:HGNC:686PA249794p14

Gene Categories:

KINASE

GO terms in RHOH


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003924GTPase activity
MFIEAGO:0003924GTPase activity
MFNASGO:0005095GTPase inhibitor activity
MFIPIGO:0005515protein binding
MFIBAGO:0005525GTP binding
MFIDAGO:0005525GTP binding
MFNASGO:0017048Rho GTPase binding
MFIDAGO:0019210kinase inhibitor activity
MFIBAGO:0019901protein kinase binding
BPNASGO:0006355regulation of transcription, DNA-templated
BPIBAGO:0007015actin filament organization
BPIBAGO:0007163establishment or maintenance of cell polarity
BPIEAGO:0007264small GTPase mediated signal transduction
BPIBAGO:0007266Rho protein signal transduction
BPIBAGO:0008360regulation of cell shape
BPIBAGO:0030036actin cytoskeleton organization
BPNASGO:0030217T cell differentiation
BPIBAGO:0030865cortical cytoskeleton organization
BPIBAGO:0032956regulation of actin cytoskeleton organization
BPIEAGO:0034260negative regulation of GTPase activity
BPIEAGO:0042326negative regulation of phosphorylation
BPIDAGO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling
BPIBAGO:0043652engulfment of apoptotic cell
BPIEAGO:0045576mast cell activation
BPTASGO:0051056regulation of small GTPase mediated signal transduction
CCIEAGO:0001772immunological synapse
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIBAGO:0005856cytoskeleton
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005938cell cortex
CCIBAGO:0031410cytoplasmic vesicle
CCIBAGO:0031982vesicle
CCIBAGO:0042995cell projection
CCIBAGO:0043231intracellular membrane-bounded organelle

Gene expression in normal tissue: RHOH

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RHOH


DatabasePathway IDPathway Des.
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD221Tamoxifen3
iGMDRD483SCH-5290743
iGMDRD280CYTOCHALASIN B3
iGMDRD353PD03259011
iGMDRD42Vorinostat3
iGMDRD883CIL55A3
iGMDRD871BRD63683
iGMDRD499PDMP3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RHOH

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