RHOH
Summary: The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ras homolog family member H | MIM:602037 | Ensembl:ENSG00000168421 | HGNC:HGNC:686 | PA24979 | 4p14 |
Gene Categories:
KINASEGO terms in RHOH
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003924 | GTPase activity |
| MF | IEA | GO:0003924 | GTPase activity |
| MF | NAS | GO:0005095 | GTPase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005525 | GTP binding |
| MF | IDA | GO:0005525 | GTP binding |
| MF | NAS | GO:0017048 | Rho GTPase binding |
| MF | IDA | GO:0019210 | kinase inhibitor activity |
| MF | IBA | GO:0019901 | protein kinase binding |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0007015 | actin filament organization |
| BP | IBA | GO:0007163 | establishment or maintenance of cell polarity |
| BP | IEA | GO:0007264 | small GTPase mediated signal transduction |
| BP | IBA | GO:0007266 | Rho protein signal transduction |
| BP | IBA | GO:0008360 | regulation of cell shape |
| BP | IBA | GO:0030036 | actin cytoskeleton organization |
| BP | NAS | GO:0030217 | T cell differentiation |
| BP | IBA | GO:0030865 | cortical cytoskeleton organization |
| BP | IBA | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IEA | GO:0034260 | negative regulation of GTPase activity |
| BP | IEA | GO:0042326 | negative regulation of phosphorylation |
| BP | IDA | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IBA | GO:0043652 | engulfment of apoptotic cell |
| BP | IEA | GO:0045576 | mast cell activation |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| CC | IEA | GO:0001772 | immunological synapse |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005938 | cell cortex |
| CC | IBA | GO:0031410 | cytoplasmic vesicle |
| CC | IBA | GO:0031982 | vesicle |
| CC | IBA | GO:0042995 | cell projection |
| CC | IBA | GO:0043231 | intracellular membrane-bounded organelle |
Gene expression in normal tissue: RHOH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RHOH
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD499 | PDMP | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RHOH
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