NPAP1
Summary: This gene is located in the Prader-Willi syndrome region on chromosome 15. This gene is biallelically expressed in adult testis and brain but is paternally imprinted in fetal brain. Defects in this gene may be associated with Prader-Willi syndrome. [provided by RefSeq, Aug 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear pore associated protein 1 | MIM:610922 | Ensembl:ENSG00000185823 | HGNC:HGNC:1190 | PA25519 | 15q11.2 |
Gene Categories:
TRANSPORTERGO terms in NPAP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IBA | GO:0008139 | nuclear localization sequence binding |
| MF | IBA | GO:0017056 | structural constituent of nuclear pore |
| CC | IEA | GO:0005637 | nuclear inner membrane |
| CC | IBA | GO:0005643 | nuclear pore |
| CC | IEA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0044613 | nuclear pore central transport channel |
| CC | IBA | GO:0044615 | nuclear pore nuclear basket |
| BP | IBA | GO:0006405 | RNA export from nucleus |
| BP | IBA | GO:0006606 | protein import into nucleus |
| BP | IEA | GO:0007275 | multicellular organism development |
| BP | NAS | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0030154 | cell differentiation |
Gene expression in normal tissue: NPAP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD2 | PK-11195 | 1 |
| iGMDRD152 | 179324-69-7 | 5 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD144 | NSC95397 | 8 |
| iGMDRD427 | ABT737 | 7 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD42 | Vorinostat | 6 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD49 | Mitomycin | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD330 | BRD4132 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NPAP1
CLASSFICATION
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