UNC79
Summary: The NALCN channel is responsible for Na(+) leak currents. The protein encoded by this gene, along with UNC80, is an accessory subunit of the NALCN channel that contributes to the Ca(2+) sensitivity of the channel. [provided by RefSeq, Sep 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| unc-79 homolog, NALCN channel complex subunit | MIM:616884 | Ensembl:ENSG00000133958 | HGNC:HGNC:19966 | PA134994003 | 14q32.12 |
GO terms in UNC79
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | TAS | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0035264 | multicellular organism growth |
| BP | IEA | GO:0048149 | behavioral response to ethanol |
Gene expression in normal tissue: UNC79
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UNC79
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-983712 | Ion channel transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 7 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD652 | UNC0638 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD662 | JQ-1 | 4 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD322 | FK 866 | 5 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 4 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD379 | BIBR-1532 | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD375 | GW-405833 | 4 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD579 | PF750 | 4 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD782 | DC-45-A2 | 6 |
| iGMDRD52 | Rotenone | 5 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD870 | BRD63610 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UNC79
CLASSFICATION
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