VRK3
Summary: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| vaccinia related kinase 3 | Ensembl:ENSG00000105053 | HGNC:HGNC:18996 | PA134923990 | 19q13.33 |
GO terms in VRK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IEA | GO:0032516 | positive regulation of phosphoprotein phosphatase activity |
| BP | IEA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0019903 | protein phosphatase binding |
Gene expression in normal tissue: VRK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in VRK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-198753 | ERK/MAPK targets |
| reactome | R-HSA-202670 | ERKs are inactivated |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD219 | Bax channel blocker | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD562 | Navitoclax | 9 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD255 | SB225002 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in VRK3
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