VRK3


Summary: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
vaccinia related kinase 3Ensembl:ENSG00000105053HGNC:HGNC:18996PA13492399019q13.33

GO terms in VRK3


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIEAGO:0032516positive regulation of phosphoprotein phosphatase activity
BPIEAGO:0070373negative regulation of ERK1 and ERK2 cascade
CCHDAGO:0005634nucleus
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005730nucleolus
CCIBAGO:0005737cytoplasm
CCIDAGO:0043231intracellular membrane-bounded organelle
MFIBAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0019903protein phosphatase binding

Gene expression in normal tissue: VRK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in VRK3


DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-198725Nuclear Events (kinase and transcription factor activation)
reactomeR-HSA-198753ERK/MAPK targets
reactomeR-HSA-202670ERKs are inactivated
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinases
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD679Bistramide A1
iGMDRD883CIL55A3
iGMDRD341Triacsin c1
iGMDRD219Bax channel blocker1
iGMDRD61Kinetin riboside1
iGMDRD499PDMP3
iGMDRD427ABT7371
iGMDRD781Sirolimus3
iGMDRD483SCH-5290743
iGMDRD126Tipifarnib3
iGMDRD60Quinoclamine3
iGMDRD505Pevonedistat3
iGMDRD872BRD71373
iGMDRD188Piperlongumine3
iGMDRD871BRD63683
iGMDRD562Navitoclax9
iGMDRD577BIX012943
iGMDRD434BMS-5369243
iGMDRD221Tamoxifen3
iGMDRD318PAC-13
iGMDRD474Avrainvillamide1
iGMDRD255SB2250026

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VRK3

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