Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].

transforming growth factor beta 2MIM:190220Ensembl:ENSG00000092969HGNC:HGNC:11768PA364821q41

GO terms in TGFB2

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCTASGO:0031093platelet alpha granule lumen
CCISSGO:0043025neuronal cell body
CCIDAGO:0062023collagen-containing extracellular matrix
BPIDAGO:0000902cell morphogenesis
BPISSGO:0001501skeletal system development
BPIDAGO:0001654eye development
BPIMPGO:0001666response to hypoxia
BPISSGO:0001822kidney development
BPIDAGO:0001837epithelial to mesenchymal transition
BPTASGO:0001837epithelial to mesenchymal transition
BPISSGO:0001843neural tube closure
BPIDAGO:0001942hair follicle development
BPISSGO:0001942hair follicle development
BPTASGO:0002576platelet degranulation
BPIDAGO:0003007heart morphogenesis
BPISSGO:0003148outflow tract septum morphogenesis
BPISSGO:0003149membranous septum morphogenesis
BPISSGO:0003179heart valve morphogenesis
BPISSGO:0003181atrioventricular valve morphogenesis
BPISSGO:0003184pulmonary valve morphogenesis
BPISSGO:0003203endocardial cushion morphogenesis
BPISSGO:0003215cardiac right ventricle morphogenesis
BPISSGO:0003222ventricular trabecula myocardium morphogenesis
BPISSGO:0003274endocardial cushion fusion
BPISSGO:0003289atrial septum primum morphogenesis
BPISSGO:0003407neural retina development
BPIDAGO:0006468protein phosphorylation
BPIDAGO:0007050cell cycle arrest
BPIBAGO:0007179transforming growth factor beta receptor signaling pathway
BPIDAGO:0007179transforming growth factor beta receptor signaling pathway
BPTASGO:0007267cell-cell signaling
BPIEPGO:0007435salivary gland morphogenesis
BPIDAGO:0007507heart development
BPIDAGO:0008219cell death
BPTASGO:0008283cell proliferation
BPIDAGO:0008284positive regulation of cell proliferation
BPIDAGO:0008285negative regulation of cell proliferation
BPIDAGO:0008347glial cell migration
BPISSGO:0008584male gonad development
BPIEPGO:0009611response to wounding
BPTASGO:0009792embryo development ending in birth or egg hatching
BPIDAGO:0010002cardioblast differentiation
BPIEAGO:0010469regulation of signaling receptor activity
BPIDAGO:0010629negative regulation of gene expression
BPIDAGO:0010634positive regulation of epithelial cell migration
BPIDAGO:0010693negative regulation of alkaline phosphatase activity
BPIDAGO:0010718positive regulation of epithelial to mesenchymal transition
BPIBAGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIDAGO:0010936negative regulation of macrophage cytokine production
BPIDAGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPIDAGO:0016477cell migration
BPIDAGO:0016525negative regulation of angiogenesis
BPIDAGO:0030199collagen fibril organization
BPIDAGO:0030307positive regulation of cell growth
BPIDAGO:0030308negative regulation of cell growth
BPISSGO:0030326embryonic limb morphogenesis
BPISSGO:0030593neutrophil chemotaxis
BPTASGO:0030593neutrophil chemotaxis
BPISSGO:0031069hair follicle morphogenesis
BPIDAGO:0032147activation of protein kinase activity
BPIDAGO:0032570response to progesterone
BPIDAGO:0032874positive regulation of stress-activated MAPK cascade
BPIMPGO:0032909regulation of transforming growth factor beta2 production
BPIDAGO:0033630positive regulation of cell adhesion mediated by integrin
BPISSGO:0035910ascending aorta morphogenesis
BPISSGO:0042060wound healing
BPIBAGO:0042127regulation of cell proliferation
BPISSGO:0042416dopamine biosynthetic process
BPIDAGO:0042493response to drug
BPTASGO:0042704uterine wall breakdown
BPIBAGO:0042981regulation of apoptotic process
BPIBAGO:0043408regulation of MAPK cascade
BPIDAGO:0043525positive regulation of neuron apoptotic process
BPIDAGO:0045216cell-cell junction organization
BPIDAGO:0045726positive regulation of integrin biosynthetic process
BPIDAGO:0045747positive regulation of Notch signaling pathway
BPIEPGO:0045778positive regulation of ossification
BPISSGO:0045787positive regulation of cell cycle
BPIDAGO:0045823positive regulation of heart contraction
BPISSGO:0046580negative regulation of Ras protein signal transduction
BPISSGO:0048103somatic stem cell division
BPIBAGO:0048468cell development
BPIEPGO:0048566embryonic digestive tract development
BPISSGO:0048666neuron development
BPTASGO:0048699generation of neurons
BPISSGO:0048839inner ear development
BPIDAGO:0050680negative regulation of epithelial cell proliferation
BPIMPGO:0050680negative regulation of epithelial cell proliferation
BPIDAGO:0050714positive regulation of protein secretion
BPTASGO:0050777negative regulation of immune response
BPISSGO:0050778positive regulation of immune response
BPIEAGO:0051781positive regulation of cell division
BPIDAGO:0051794regulation of timing of catagen
BPIDAGO:0051795positive regulation of timing of catagen
BPIDAGO:0051891positive regulation of cardioblast differentiation
BPIDAGO:0060038cardiac muscle cell proliferation
BPISSGO:0060065uterus development
BPIDAGO:0060317cardiac epithelial to mesenchymal transition
BPIDAGO:0060389pathway-restricted SMAD protein phosphorylation
BPIBAGO:0060395SMAD protein signal transduction
BPIDAGO:0060395SMAD protein signal transduction
BPISSGO:0060412ventricular septum morphogenesis
BPISSGO:0060413atrial septum morphogenesis
BPISSGO:0061626pharyngeal arch artery morphogenesis
BPISSGO:0062009secondary palate development
BPIDAGO:0097191extrinsic apoptotic signaling pathway
BPISSGO:1902256regulation of apoptotic process involved in outflow tract morphogenesis
BPIDAGO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II
BPIMPGO:1903659regulation of complement-dependent cytotoxicity
BPISSGO:1903701substantia propria of cornea development
BPISSGO:1904888cranial skeletal system development
BPISSGO:1905006negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
BPISSGO:1905007positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
MFIDAGO:0001540amyloid-beta binding
MFIMPGO:0005102signaling receptor binding
MFIBAGO:0005114type II transforming growth factor beta receptor binding
MFIDAGO:0005114type II transforming growth factor beta receptor binding
MFIMPGO:0005114type II transforming growth factor beta receptor binding
MFIPIGO:0005114type II transforming growth factor beta receptor binding
MFIBAGO:0005125cytokine activity
MFTASGO:0005125cytokine activity
MFIBAGO:0005160transforming growth factor beta receptor binding
MFIDAGO:0005160transforming growth factor beta receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0008083growth factor activity
MFIMPGO:0034714type III transforming growth factor beta receptor binding
MFIPIGO:0034714type III transforming growth factor beta receptor binding
MFIDAGO:0042803protein homodimerization activity
MFTASGO:0046982protein heterodimerization activity

Gene expression in normal tissue: TGFB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TGFB2

DatabasePathway IDPathway Des.
wikipathwaysWP2870Extracellular vesicle-mediated signaling in recipient cells
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP400p38 MAPK Signaling Pathway
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP4241Type 2 papillary renal cell carcinoma
wikipathwaysWP474Endochondral Ossification
pidatf2_pathwayATF-2 transcription factor network
pidhedgehog_2pathwaySignaling events mediated by the Hedgehog family
pidrb_1pathwayRegulation of retinoblastoma protein
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05144Malaria - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)
biocartaalkpathwayalk in cardiac myocytes
biocartactcfpathwayctcf: first multivalent nuclear factor
biocartail1rpathwaysignal transduction through il1r
biocartanthipathwaynfkb activation by nontypeable hemophilus influenzae
biocartatgfbpathwaytgf beta signaling pathway
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1566948Elastic fibre formation
reactomeR-HSA-2129379Molecules associated with elastic fibres
reactomeR-HSA-3000178ECM proteoglycans
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD85Ursolic acid3
iGMDRD267Oligomycin A6
iGMDRD5Tyrphostin AG 14783

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TGFB2