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TGFB2

Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
transforming growth factor beta 2	MIM:190220	Ensembl:ENSG00000092969	HGNC:HGNC:11768	PA36482	1q41

Gene Categories:

GROWTH FACTOR DRUG RESISTANCE DRUGGABLE GENOME TUMOR SUPPRESSOR KINASE

GO terms in TGFB2

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005576	extracellular region
CC	TAS	GO:0005576	extracellular region
CC	IBA	GO:0005615	extracellular space
CC	IDA	GO:0005615	extracellular space
CC	ISS	GO:0030424	axon
CC	TAS	GO:0031093	platelet alpha granule lumen
CC	ISS	GO:0043025	neuronal cell body
CC	IDA	GO:0062023	collagen-containing extracellular matrix
BP	IDA	GO:0000902	cell morphogenesis
BP	ISS	GO:0001501	skeletal system development
BP	TAS	GO:0001525	angiogenesis
BP	IDA	GO:0001654	eye development
BP	IMP	GO:0001666	response to hypoxia
BP	ISS	GO:0001822	kidney development
BP	IDA	GO:0001837	epithelial to mesenchymal transition
BP	TAS	GO:0001837	epithelial to mesenchymal transition
BP	ISS	GO:0001843	neural tube closure
BP	IDA	GO:0001942	hair follicle development
BP	ISS	GO:0001942	hair follicle development
BP	TAS	GO:0002576	platelet degranulation
BP	IDA	GO:0003007	heart morphogenesis
BP	ISS	GO:0003148	outflow tract septum morphogenesis
BP	ISS	GO:0003149	membranous septum morphogenesis
BP	ISS	GO:0003179	heart valve morphogenesis
BP	ISS	GO:0003181	atrioventricular valve morphogenesis
BP	ISS	GO:0003184	pulmonary valve morphogenesis
BP	ISS	GO:0003203	endocardial cushion morphogenesis
BP	ISS	GO:0003215	cardiac right ventricle morphogenesis
BP	ISS	GO:0003222	ventricular trabecula myocardium morphogenesis
BP	ISS	GO:0003274	endocardial cushion fusion
BP	ISS	GO:0003289	atrial septum primum morphogenesis
BP	ISS	GO:0003407	neural retina development
BP	IDA	GO:0006468	protein phosphorylation
BP	IDA	GO:0007050	cell cycle arrest
BP	IBA	GO:0007179	transforming growth factor beta receptor signaling pathway
BP	IDA	GO:0007179	transforming growth factor beta receptor signaling pathway
BP	TAS	GO:0007267	cell-cell signaling
BP	IEP	GO:0007435	salivary gland morphogenesis
BP	IDA	GO:0007507	heart development
BP	IDA	GO:0008219	cell death
BP	TAS	GO:0008283	cell proliferation
BP	IDA	GO:0008284	positive regulation of cell proliferation
BP	IDA	GO:0008285	negative regulation of cell proliferation
BP	IDA	GO:0008347	glial cell migration
BP	ISS	GO:0008584	male gonad development
BP	IEP	GO:0009611	response to wounding
BP	TAS	GO:0009792	embryo development ending in birth or egg hatching
BP	IDA	GO:0010002	cardioblast differentiation
BP	IEA	GO:0010469	regulation of signaling receptor activity
BP	IDA	GO:0010629	negative regulation of gene expression
BP	IDA	GO:0010634	positive regulation of epithelial cell migration
BP	IDA	GO:0010693	negative regulation of alkaline phosphatase activity
BP	IDA	GO:0010718	positive regulation of epithelial to mesenchymal transition
BP	IBA	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
BP	IDA	GO:0010936	negative regulation of macrophage cytokine production
BP	IDA	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
BP	IDA	GO:0016477	cell migration
BP	IDA	GO:0016525	negative regulation of angiogenesis
BP	ISS	GO:0030097	hemopoiesis
BP	IDA	GO:0030199	collagen fibril organization
BP	IDA	GO:0030307	positive regulation of cell growth
BP	IDA	GO:0030308	negative regulation of cell growth
BP	ISS	GO:0030326	embryonic limb morphogenesis
BP	ISS	GO:0030593	neutrophil chemotaxis
BP	TAS	GO:0030593	neutrophil chemotaxis
BP	ISS	GO:0031069	hair follicle morphogenesis
BP	IDA	GO:0032147	activation of protein kinase activity
BP	IDA	GO:0032570	response to progesterone
BP	IDA	GO:0032874	positive regulation of stress-activated MAPK cascade
BP	IMP	GO:0032909	regulation of transforming growth factor beta2 production
BP	IDA	GO:0033630	positive regulation of cell adhesion mediated by integrin
BP	ISS	GO:0035910	ascending aorta morphogenesis
BP	ISS	GO:0042060	wound healing
BP	IBA	GO:0042127	regulation of cell proliferation
BP	ISS	GO:0042416	dopamine biosynthetic process
BP	NAS	GO:0042476	odontogenesis
BP	IDA	GO:0042493	response to drug
BP	TAS	GO:0042704	uterine wall breakdown
BP	IBA	GO:0042981	regulation of apoptotic process
BP	IBA	GO:0043408	regulation of MAPK cascade
BP	IDA	GO:0043525	positive regulation of neuron apoptotic process
BP	IDA	GO:0045216	cell-cell junction organization
BP	IDA	GO:0045726	positive regulation of integrin biosynthetic process
BP	IDA	GO:0045747	positive regulation of Notch signaling pathway
BP	IEP	GO:0045778	positive regulation of ossification
BP	ISS	GO:0045787	positive regulation of cell cycle
BP	IDA	GO:0045823	positive regulation of heart contraction
BP	ISS	GO:0046580	negative regulation of Ras protein signal transduction
BP	ISS	GO:0048103	somatic stem cell division
BP	IBA	GO:0048468	cell development
BP	IEP	GO:0048566	embryonic digestive tract development
BP	ISS	GO:0048666	neuron development
BP	TAS	GO:0048699	generation of neurons
BP	ISS	GO:0048839	inner ear development
BP	IDA	GO:0050680	negative regulation of epithelial cell proliferation
BP	IMP	GO:0050680	negative regulation of epithelial cell proliferation
BP	IDA	GO:0050714	positive regulation of protein secretion
BP	TAS	GO:0050777	negative regulation of immune response
BP	ISS	GO:0050778	positive regulation of immune response
BP	IEA	GO:0051781	positive regulation of cell division
BP	IDA	GO:0051794	regulation of timing of catagen
BP	IDA	GO:0051795	positive regulation of timing of catagen
BP	IDA	GO:0051891	positive regulation of cardioblast differentiation
BP	IDA	GO:0060038	cardiac muscle cell proliferation
BP	ISS	GO:0060065	uterus development
BP	IDA	GO:0060317	cardiac epithelial to mesenchymal transition
BP	IDA	GO:0060389	pathway-restricted SMAD protein phosphorylation
BP	IBA	GO:0060395	SMAD protein signal transduction
BP	IDA	GO:0060395	SMAD protein signal transduction
BP	ISS	GO:0060412	ventricular septum morphogenesis
BP	ISS	GO:0060413	atrial septum morphogenesis
BP	ISS	GO:0061626	pharyngeal arch artery morphogenesis
BP	ISS	GO:0062009	secondary palate development
BP	IDA	GO:0097191	extrinsic apoptotic signaling pathway
BP	ISS	GO:1902256	regulation of apoptotic process involved in outflow tract morphogenesis
BP	IDA	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II
BP	IMP	GO:1903659	regulation of complement-dependent cytotoxicity
BP	ISS	GO:1903701	substantia propria of cornea development
BP	ISS	GO:1904888	cranial skeletal system development
BP	ISS	GO:1905006	negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
BP	ISS	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
MF	IDA	GO:0001540	amyloid-beta binding
MF	IMP	GO:0005102	signaling receptor binding
MF	IBA	GO:0005114	type II transforming growth factor beta receptor binding
MF	IDA	GO:0005114	type II transforming growth factor beta receptor binding
MF	IMP	GO:0005114	type II transforming growth factor beta receptor binding
MF	IPI	GO:0005114	type II transforming growth factor beta receptor binding
MF	IBA	GO:0005125	cytokine activity
MF	TAS	GO:0005125	cytokine activity
MF	IBA	GO:0005160	transforming growth factor beta receptor binding
MF	IDA	GO:0005160	transforming growth factor beta receptor binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0008083	growth factor activity
MF	IMP	GO:0034714	type III transforming growth factor beta receptor binding
MF	IPI	GO:0034714	type III transforming growth factor beta receptor binding
MF	IDA	GO:0042803	protein homodimerization activity
MF	TAS	GO:0046982	protein heterodimerization activity

Gene expression in normal tissue: TGFB2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TGFB2

Database	Pathway ID	Pathway Des.
wikipathways	WP2870	Extracellular vesicle-mediated signaling in recipient cells
wikipathways	WP2877	Vitamin D Receptor Pathway
wikipathways	WP2882	Nuclear Receptors Meta-Pathway
wikipathways	WP2884	NRF2 pathway
wikipathways	WP382	MAPK Signaling Pathway
wikipathways	WP400	p38 MAPK Signaling Pathway
wikipathways	WP4018	Pathways in clear cell renal cell carcinoma
wikipathways	WP4216	Chromosomal and microsatellite instability in colorectal cancer
wikipathways	WP4239	EMT transition in Colorectal Cancer
wikipathways	WP4241	Type 2 papillary renal cell carcinoma
wikipathways	WP474	Endochondral Ossification
pid	atf2_pathway	ATF-2 transcription factor network
pid	hedgehog_2pathway	Signaling events mediated by the Hedgehog family
pid	rb_1pathway	Regulation of retinoblastoma protein
netpath	Pathway_TGF_beta_Receptor	TGF_beta_Receptor
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04060	Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg	hsa04068	FoxO signaling pathway - Homo sapiens (human)
kegg	hsa04110	Cell cycle - Homo sapiens (human)
kegg	hsa04218	Cellular senescence - Homo sapiens (human)
kegg	hsa04350	TGF-beta signaling pathway - Homo sapiens (human)
kegg	hsa04380	Osteoclast differentiation - Homo sapiens (human)
kegg	hsa04390	Hippo signaling pathway - Homo sapiens (human)
kegg	hsa04933	AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegg	hsa05140	Leishmaniasis - Homo sapiens (human)
kegg	hsa05142	Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegg	hsa05144	Malaria - Homo sapiens (human)
kegg	hsa05145	Toxoplasmosis - Homo sapiens (human)
kegg	hsa05146	Amoebiasis - Homo sapiens (human)
kegg	hsa05152	Tuberculosis - Homo sapiens (human)
kegg	hsa05161	Hepatitis B - Homo sapiens (human)
kegg	hsa05166	HTLV-I infection - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05205	Proteoglycans in cancer - Homo sapiens (human)
kegg	hsa05206	MicroRNAs in cancer - Homo sapiens (human)
kegg	hsa05210	Colorectal cancer - Homo sapiens (human)
kegg	hsa05211	Renal cell carcinoma - Homo sapiens (human)
kegg	hsa05212	Pancreatic cancer - Homo sapiens (human)
kegg	hsa05220	Chronic myeloid leukemia - Homo sapiens (human)
kegg	hsa05225	Hepatocellular carcinoma - Homo sapiens (human)
kegg	hsa05226	Gastric cancer - Homo sapiens (human)
kegg	hsa05321	Inflammatory bowel disease (IBD) - Homo sapiens (human)
kegg	hsa05323	Rheumatoid arthritis - Homo sapiens (human)
kegg	hsa05410	Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegg	hsa05414	Dilated cardiomyopathy (DCM) - Homo sapiens (human)
biocarta	alkpathway	alk in cardiac myocytes
biocarta	ctcfpathway	ctcf: first multivalent nuclear factor
biocarta	il1rpathway	signal transduction through il1r
biocarta	nthipathway	nfkb activation by nontypeable hemophilus influenzae
biocarta	tgfbpathway	tgf beta signaling pathway
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-114608	Platelet degranulation
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1566948	Elastic fibre formation
reactome	R-HSA-2129379	Molecules associated with elastic fibres
reactome	R-HSA-3000178	ECM proteoglycans
reactome	R-HSA-76002	Platelet activation, signaling and aggregation
reactome	R-HSA-76005	Response to elevated platelet cytosolic Ca2+

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD375	GW-405833	3
iGMDRD562	Navitoclax	3
iGMDRD2	PK-11195	3
iGMDRD85	Ursolic acid	3
iGMDRD267	Oligomycin A	6
iGMDRD221	Tamoxifen	3
iGMDRD5	Tyrphostin AG 1478	3
iGMDRD599	Salermide	6
iGMDRD330	BRD4132	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TGFB2

SITE

DATATYPES

CLASSFICATION

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