SPTAN1


Summary: Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
spectrin alpha, non-erythrocytic 1MIM:182810Ensembl:ENSG00000197694HGNC:HGNC:11273PA361029q34.11

GO terms in SPTAN1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003779actin binding
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFTASGO:0005200structural constituent of cytoskeleton
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIEAGO:0005516calmodulin binding
MFHDAGO:0045296cadherin binding
BPTASGO:0000165MAPK cascade
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPIEAGO:0007010cytoskeleton organization
BPTASGO:0007411axon guidance
BPTASGO:0043312neutrophil degranulation
BPIEAGO:0051693actin filament capping
CCTASGO:0005576extracellular region
CCTASGO:0005829cytosol
CCTASGO:0008091spectrin
CCIDAGO:0015630microtubule cytoskeleton
CCTASGO:0016020membrane
CCTASGO:0035580specific granule lumen
CCIDAGO:0043231intracellular membrane-bounded organelle
CCHDAGO:0070062extracellular exosome
CCHDAGO:1903561extracellular vesicle
CCTASGO:1904724tertiary granule lumen

Gene expression in normal tissue: SPTAN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SPTAN1


DatabasePathway IDPathway Des.
biocartadeathpathwayinduction of apoptosis through dr3 and dr4/5 death receptors
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartaucalpainpathwayucalpain and friends in cell spread
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-111465Apoptotic cleavage of cellular proteins
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-264870Caspase-mediated cleavage of cytoskeletal proteins
reactomeR-HSA-373753Nephrin family interactions
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445095Interaction between L1 and Ankyrins
reactomeR-HSA-445095Interaction between L1 and Ankyrins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-6807878COPI-mediated anterograde transport
reactomeR-HSA-75153Apoptotic execution phase
reactomeR-HSA-948021Transport to the Golgi and subsequent modification
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
pidcaspase_pathwayCaspase Cascade in Apoptosis
kegghsa04210Apoptosis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD152179324-69-71
iGMDRD61Kinetin riboside5
iGMDRD280CYTOCHALASIN B3
iGMDRD889Compound 7d-cis3
iGMDRD387CHIR-990212
iGMDRD772BRD47703
iGMDRD151CHM-14
iGMDRD433Lexibulin2
iGMDRD494Neopeltolide4
iGMDRD781Sirolimus1
iGMDRD144NSC953973
iGMDRD562Navitoclax2
iGMDRD188Piperlongumine4
iGMDRD399Selumetinib3
iGMDRD356PNU-746542
iGMDRD598QS-112
iGMDRD524ISX-93
iGMDRD255SB2250022
iGMDRD260FQI-23
iGMDRD138PX 123
iGMDRD318PAC-14
iGMDRD870BRD636103
iGMDRD187BRD98762
iGMDRD351GW843682X6
iGMDRD499PDMP3
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD607Ubistatin B2
iGMDRD307Manumycin A3
iGMDRD405PIK-753
iGMDRD532Olaparib2
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD662JQ-12
iGMDRD329Merck602
iGMDRD286Nsc 6328396
iGMDRD871BRD63683
iGMDRD872BRD71373
iGMDRD42Vorinostat2
iGMDRD82Quiflapon3
iGMDRD505Pevonedistat3
iGMDRD147Prima-12
iGMDRD552AZD-17752
iGMDRD103SN-383
iGMDRD271Brefeldin A3
iGMDRD202Curcumin6
iGMDRD137Indisulam2
iGMDRD77Itraconazole3
iGMDRD705Nakiterpiosin4
iGMDRD221Tamoxifen3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPTAN1

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