STAT3


Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
signal transducer and activator of transcription 3MIM:102582Ensembl:ENSG00000168610HGNC:HGNC:11364PA33717q21.2

GO terms in STAT3


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIMPGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIPIGO:0001103RNA polymerase II repressing transcription factor binding
MFIDAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFISSGO:0003677DNA binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0004879nuclear receptor activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFISSGO:0019901protein kinase binding
MFIPIGO:0019903protein phosphatase binding
MFIDAGO:0031490chromatin DNA binding
MFIEAGO:0031730CCR5 chemokine receptor binding
MFIEAGO:0035259glucocorticoid receptor binding
MFIPIGO:0042802identical protein binding
MFISSGO:0042803protein homodimerization activity
MFIDAGO:0044212transcription regulatory region DNA binding
MFISSGO:0046983protein dimerization activity
BPTASGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0001659temperature homeostasis
BPISSGO:0001754eye photoreceptor cell differentiation
BPIDAGO:0006355regulation of transcription, DNA-templated
BPISSGO:0006357regulation of transcription by RNA polymerase II
BPIDAGO:0006606protein import into nucleus
BPIEAGO:0006953acute-phase response
BPISSGO:0006954inflammatory response
BPTASGO:0007165signal transduction
BPTASGO:0007259JAK-STAT cascade
BPTASGO:0007399nervous system development
BPIEAGO:0007568aging
BPIEAGO:0008283cell proliferation
BPIEAGO:0008285negative regulation of cell proliferation
BPIDAGO:0010628positive regulation of gene expression
BPIMPGO:0010628positive regulation of gene expression
BPIEAGO:0010730negative regulation of hydrogen peroxide biosynthetic process
BPIEAGO:0016032viral process
BPISSGO:0016310phosphorylation
BPNASGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPISSGO:0019953sexual reproduction
BPIDAGO:0030522intracellular receptor signaling pathway
BPIDAGO:0032355response to estradiol
BPIDAGO:0032870cellular response to hormone stimulus
BPIDAGO:0033210leptin-mediated signaling pathway
BPTASGO:0035019somatic stem cell population maintenance
BPIDAGO:0035278miRNA mediated inhibition of translation
BPTASGO:0035723interleukin-15-mediated signaling pathway
BPTASGO:0038111interleukin-7-mediated signaling pathway
BPTASGO:0038114interleukin-21-mediated signaling pathway
BPTASGO:0038155interleukin-23-mediated signaling pathway
BPIEAGO:0040014regulation of multicellular organism growth
BPTASGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPISSGO:0042593glucose homeostasis
BPISSGO:0042755eating behavior
BPIEAGO:0042789mRNA transcription by RNA polymerase II
BPIMPGO:0043066negative regulation of apoptotic process
BPIDAGO:0044320cellular response to leptin stimulus
BPIDAGO:0044321response to leptin
BPIEAGO:0045471response to ethanol
BPIMPGO:0045648positive regulation of erythrocyte differentiation
BPISSGO:0045747positive regulation of Notch signaling pathway
BPIEAGO:0045766positive regulation of angiogenesis
BPIEAGO:0045820negative regulation of glycolytic process
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIGIGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046902regulation of mitochondrial membrane permeability
BPISSGO:0048708astrocyte differentiation
BPIDAGO:0051726regulation of cell cycle
BPISSGO:0060019radial glial cell differentiation
BPISSGO:0060259regulation of feeding behavior
BPIDAGO:0060396growth hormone receptor signaling pathway
BPIDAGO:0060397JAK-STAT cascade involved in growth hormone signaling pathway
BPISSGO:0060397JAK-STAT cascade involved in growth hormone signaling pathway
BPIDAGO:0070102interleukin-6-mediated signaling pathway
BPIMPGO:0070102interleukin-6-mediated signaling pathway
BPTASGO:0070102interleukin-6-mediated signaling pathway
BPTASGO:0070106interleukin-27-mediated signaling pathway
BPTASGO:0070757interleukin-35-mediated signaling pathway
BPTASGO:0071345cellular response to cytokine stimulus
BPIEAGO:0071407cellular response to organic cyclic compound
BPISSGO:0072540T-helper 17 cell lineage commitment
BPISSGO:0097009energy homeostasis
BPIEAGO:1901215negative regulation of neuron death
BPIEAGO:1902728positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
BPIDAGO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II
BPIGIGO:1904685positive regulation of metalloendopeptidase activity
BPIEAGO:1905564positive regulation of vascular endothelial cell proliferation
BPIDAGO:2000637positive regulation of gene silencing by miRNA
BPIEAGO:2000737negative regulation of stem cell differentiation
BPIEAGO:2001171positive regulation of ATP biosynthetic process
BPIEAGO:2001223negative regulation of neuron migration
CCIDAGO:0000790nuclear chromatin
CCIDAGO:0005634nucleus
CCISSGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCISSGO:0005737cytoplasm
CCIEAGO:0005743mitochondrial inner membrane
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCISSGO:0005886plasma membrane
CCICGO:0090575RNA polymerase II transcription factor complex
CCIMPGO:0090575RNA polymerase II transcription factor complex

Gene expression in normal tissue: STAT3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STAT3


DatabasePathway IDPathway Des.
wikipathwaysWP127IL-5 Signaling Pathway
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1528Physiological and Pathological Hypertrophy of the Heart
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP1559TFs Regulate miRNAs related to cardiac hypertrophy
wikipathwaysWP2023Cell Differentiation - Index expanded
wikipathwaysWP2029Cell Differentiation - Index
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2038Regulation of Microtubule Cytoskeleton
wikipathwaysWP205IL-7 Signaling Pathway
wikipathwaysWP2112IL17 signaling pathway
wikipathwaysWP22IL-9 Signaling Pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP236Adipogenesis
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2593JAK-STAT
wikipathwaysWP2815Mammary gland development pathway - Involution (Stage 4 of 4)
wikipathwaysWP2855Dopaminergic Neurogenesis
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP2868TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
wikipathwaysWP2881Estrogen Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP313Signaling of Hepatocyte Growth Factor Receptor
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3333POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
wikipathwaysWP364IL-6 signaling pathway
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3892Development of pulmonary dendritic cells and macrophage subsets
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3935Leptin Insulin Overlap
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP3987HDAC6 interactions
wikipathwaysWP3995Prion disease pathway
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP49IL-2 Signaling Pathway
wikipathwaysWP560TGF-beta Receptor Signaling
wikipathwaysWP581EPO Receptor Signaling
wikipathwaysWP585Interferon type I signaling pathways
wikipathwaysWP61Notch Signaling Pathway
wikipathwaysWP733Serotonin Receptor 2 and STAT3 Signaling
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165374494Busulfan Pathway, Pharmacodynamics
pidcxcr4_pathwayCXCR4-mediated signaling events
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
pidfgf_pathwayFGF signaling pathway
pidgmcsf_pathwayGMCSF-mediated signaling events
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidhes_heypathwayNotch-mediated HES/HEY network
pidil12_2pathwayIL12-mediated signaling events
pidil12_stat4pathwayIL12 signaling mediated by STAT4
pidil23pathwayIL23-mediated signaling events
pidil27pathwayIL27-mediated signaling events
pidil2_1pathwayIL2-mediated signaling events
pidil6_7pathwayIL6-mediated signaling events
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidptp1bpathwaySignaling events mediated by PTP1B
pidrac1_pathwayRAC1 signaling pathway
pidtcptp_pathwaySignaling events mediated by TCPTP
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_BCRBCR
netpathPathway_EGFR1EGFR1
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
netpathPathway_GastrinGastrin
netpathPathway_IL-7IL-7
netpathPathway_IL11IL11
netpathPathway_IL2IL2
netpathPathway_IL4IL4
netpathPathway_IL5IL5
netpathPathway_IL6IL6
netpathPathway_IL9IL9
netpathPathway_KitReceptorKitReceptor
netpathPathway_LeptinLeptin
netpathPathway_NotchNotch
netpathPathway_Oncostatin_MOncostatin_M
netpathPathway_ProlactinProlactin
netpathPathway_RAGERAGE
netpathPathway_TSLPTSLP
biocartabiopeptidespathwaybioactive peptide induced signaling pathway
biocartaegfpathwayegf signaling pathway
biocartaerkpathwayerk1/erk2 mapk signaling pathway
biocartaher2pathwayrole of erbb2 in signal transduction and oncology
biocartail22bppathwayil22 soluble receptor signaling pathway
biocartail6pathwayil 6 signaling pathway
biocartapdgfpathwaypdgf signaling pathway
biocartastat3pathwaystat3 signaling pathway
biocartatpopathwaytpo signaling pathway
reactomeR-HSA-1059683Interleukin-6 signaling
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111453BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-1839117Signaling by cytosolic FGFR1 fusion mutants
reactomeR-HSA-1839124FGFR1 mutant receptor activation
reactomeR-HSA-186763Downstream signal transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-198745Signalling to STAT3
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2586552Signaling by Leptin
reactomeR-HSA-2892247POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
reactomeR-HSA-390466Chaperonin-mediated protein folding
reactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesis
reactomeR-HSA-391251Protein folding
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-447115Interleukin-12 family signaling
reactomeR-HSA-447115Interleukin-12 family signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-452723Transcriptional regulation of pluripotent stem cells
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5655302Signaling by FGFR1 in disease
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-6783589Interleukin-6 family signaling
reactomeR-HSA-6783783Interleukin-10 signaling
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8849474PTK6 Activates STAT3
reactomeR-HSA-8849474PTK6 Activates STAT3
reactomeR-HSA-8854691Interleukin-20 family signaling
reactomeR-HSA-8875791MET activates STAT3
reactomeR-HSA-8875791MET activates STAT3
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-8983432Interleukin-15 signaling
reactomeR-HSA-8984722Interleukin-35 Signalling
reactomeR-HSA-8985947Interleukin-9 signaling
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9008059Interleukin-37 signaling
reactomeR-HSA-9020933Interleukin-23 signaling
reactomeR-HSA-9020933Interleukin-23 signaling
reactomeR-HSA-9020956Interleukin-27 signaling
reactomeR-HSA-9020958Interleukin-21 signaling
reactomeR-HSA-982772Growth hormone receptor signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD201SKI II3
iGMDRD280CYTOCHALASIN B4
iGMDRD394BX-7951
iGMDRD634SCHEMBL26080413
iGMDRD126Tipifarnib9
iGMDRD554CHEMBL14341373
iGMDRD772BRD47702
iGMDRD546BMS-7548076
iGMDRD779PRL-3 Inhibitor I3
iGMDRD781Sirolimus6
iGMDRD354Midostaurin1
iGMDRD506Fedratinib2
iGMDRD562Navitoclax3
iGMDRD60Quinoclamine2
iGMDRD23Gossypol3
iGMDRD356PNU-746543
iGMDRD270Ciclosporin2
iGMDRD474Avrainvillamide2
iGMDRD138PX 123
iGMDRD255SB2250022
iGMDRD318PAC-12
iGMDRD57Chloropentafluorobenzene3
iGMDRD219Bax channel blocker2
iGMDRD84Lovastatin acid3
iGMDRD116CD4372
iGMDRD424Tamatinib2
iGMDRD286Nsc 6328393
iGMDRD871BRD63683
iGMDRD872BRD71372
iGMDRD505Pevonedistat4
iGMDRD300Tozasertib5
iGMDRD552AZD-17753
iGMDRD82Quiflapon3
iGMDRD137Indisulam3
iGMDRD6AM-5803
iGMDRD221Tamoxifen3
iGMDRD434BMS-5369242
iGMDRD267Oligomycin A1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STAT3

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