STAT3

Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namesignal transducer and activator of transcription 3
OMIM IDMIM:102582
Ensembl IDEnsembl:ENSG00000168610
HGNC IDHGNC:HGNC:11364
PHARMGKB IDPA337
Map Location17q21.2

GO terms in STAT3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IMP GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF IPI GO:0001103 RNA polymerase II repressing transcription factor binding
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Gene expression in normal tissue: STAT3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 72BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 7BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 21UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 6OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 4BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 2

Gene-drug pathway distribution

undefined29Apoptosis regulation2Mitosis1Drug metabolism - cytochrome P4501Th17 cell differentiation1Biosynthesis of secondary metabolites1Other, kinases1IGFR signaling1Longevity regulating pathway1

Pathways in STAT3


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Database
Pathway ID
Pathway Des.
wikipathways WP127 IL-5 Signaling Pathway
wikipathways WP138 Androgen receptor signaling pathway
wikipathways WP1528 Physiological and Pathological Hypertrophy of the Heart
wikipathways WP1544 MicroRNAs in cardiomyocyte hypertrophy
wikipathways WP1559 TFs Regulate miRNAs related to cardiac hypertrophy
wikipathways WP2023 Cell Differentiation - Index expanded
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD201 SKI II 3
iGMDRD280 CYTOCHALASIN B 4
iGMDRD394 BX-795 1
iGMDRD634 SCHEMBL2608041 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STAT3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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