KIAA1549
Summary: The protein encoded by this gene belongs to the UPF0606 family. This gene has been found to be fused to the BRAF oncogene in many cases of pilocytic astrocytoma. The fusion results from 2Mb tandem duplications at 7q34. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| KIAA1549 | MIM:613344 | Ensembl:ENSG00000122778 | HGNC:HGNC:22219 | PA162393138 | 7q34 |
GO terms in KIAA1549
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
Gene expression in normal tissue: KIAA1549
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KIAA1549
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD193 | Fqi1 | 6 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD427 | ABT737 | 7 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD598 | QS-11 | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD260 | FQI-2 | 4 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD103 | SN-38 | 5 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD158 | NSC141540 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KIAA1549
CLASSFICATION
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