BIK
Summary: The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603392 Ensembl IDEnsembl:ENSG00000100290 HGNC IDHGNC:HGNC:1051 PHARMGKB IDPA25354 Map Location22q13.2 | |||||
GO terms in BIK
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | IEA | GO:0012505 | endomembrane system |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031966 | mitochondrial membrane |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IBA | GO:0008584 | male gonad development |
Gene expression in normal tissue: BIK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BIK
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | mitochondriapathway | role of mitochondria in apoptotic signaling |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| pharmgkb | PA165374494 | Busulfan Pathway, Pharmacodynamics |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BIK
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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