BIK
Summary: The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BCL2 interacting killer | MIM:603392 | Ensembl:ENSG00000100290 | HGNC:HGNC:1051 | PA25354 | 22q13.2 |
GO terms in BIK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | IEA | GO:0012505 | endomembrane system |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031966 | mitochondrial membrane |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IBA | GO:0008584 | male gonad development |
| BP | IBA | GO:0008637 | apoptotic mitochondrial changes |
| BP | IDA | GO:0032464 | positive regulation of protein homooligomerization |
| BP | IDA | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
Gene expression in normal tissue: BIK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BIK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | mitochondriapathway | role of mitochondria in apoptotic signaling |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| pharmgkb | PA165374494 | Busulfan Pathway, Pharmacodynamics |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD441 | TW 37 | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD67 | PENFLURIDOL | 6 |
| iGMDRD414 | MST-312 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BIK
CLASSFICATION
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