RET

Summary: This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameret proto-oncogene
OMIM IDMIM:164761
Ensembl IDEnsembl:ENSG00000165731
HGNC IDHGNC:HGNC:9967
PHARMGKB IDPA34335
Map Location10q11.21

GO terms in RET


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0000165 MAPK cascade
BP IMP GO:0000187 activation of MAPK activity
BP IEA GO:0001657 ureteric bud development
BP IEA GO:0001755 neural crest cell migration
BP IEA GO:0001838 embryonic epithelial tube formation
BP TAS GO:0006468 protein phosphorylation
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Gene expression in normal tissue: RET

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 23undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 85undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 33OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 6THYROItissue: THYROI cancer: THYROID model num: 0THYROIDtissue: THYROID cancer: Thyroid Cancer model num: 14THYROIDtissue: THYROID cancer: Medullary Thyroid Cancer (THME) model num: 8BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Adenocarcinoma, NOS (ADNOS) model num: 1

Gene-drug pathway distribution

Pathways in RET


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-422475 Axon guidance
reactome R-HSA-5673001 RAF/MAP kinase cascade
reactome R-HSA-5683057 MAPK family signaling cascades
reactome R-HSA-5684996 MAPK1/MAPK3 signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD999 RET inhibitor 4
iGMDRD116 CD437 3
iGMDRD770 Hydroxy Vandetanib 1
iGMDRD512 nutlin 3 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RET

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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