COL4A3BP

Summary: This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecollagen type IV alpha 3 binding protein
OMIM IDMIM:604677
Ensembl IDEnsembl:ENSG00000113163
HGNC IDHGNC:HGNC:2205
PHARMGKB IDPA26720
Map Location5q13.3

Gene Categories:

KINASETRANSPORTER

GO terms in COL4A3BP


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IBA GO:0008289 lipid binding
MF IBA GO:0070273 phosphatidylinositol-4-phosphate binding
MF IDA GO:0097001 ceramide binding
MF IDA GO:0120017 intermembrane ceramide transfer activity
MF IBA GO:1902387 ceramide 1-phosphate binding
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Gene expression in normal tissue: COL4A3BP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined20Apoptosis regulation2Drug metabolism - cytochrome P4501p53 pathway1Other, kinases1One carbon pool by folate1Biosynthesis of secondary metabolites1Chromatin histone methylation1Longevity regulating pathway1Cell cycle1

Pathways in COL4A3BP


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1660661 Sphingolipid de novo biosynthesis
reactome R-HSA-428157 Sphingolipid metabolism
reactome R-HSA-556833 Metabolism of lipids
wikipathways WP1422 Sphingolipid Metabolism
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD79 Gemcitabine 3
iGMDRD652 UNC0638 3
iGMDRD781 Sirolimus 3
iGMDRD420 Leucascandrolide A 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COL4A3BP

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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