COL4A3BP
Summary: This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| collagen type IV alpha 3 binding protein | MIM:604677 | Ensembl:ENSG00000113163 | HGNC:HGNC:2205 | PA26720 | 5q13.3 |
GO terms in COL4A3BP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008289 | lipid binding |
| MF | IBA | GO:0070273 | phosphatidylinositol-4-phosphate binding |
| MF | IDA | GO:0097001 | ceramide binding |
| MF | IDA | GO:0120017 | intermembrane ceramide transfer activity |
| MF | IBA | GO:1902387 | ceramide 1-phosphate binding |
| MF | IBA | GO:1902388 | ceramide 1-phosphate transporter activity |
| BP | NAS | GO:0006955 | immune response |
| BP | TAS | GO:0030148 | sphingolipid biosynthetic process |
| BP | IBA | GO:0035621 | ER to Golgi ceramide transport |
| BP | IMP | GO:0035621 | ER to Golgi ceramide transport |
| BP | IBA | GO:0035627 | ceramide transport |
| BP | IBA | GO:0120009 | intermembrane lipid transfer |
| BP | IDA | GO:0120012 | intermembrane sphingolipid transfer |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0016020 | membrane |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: COL4A3BP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in COL4A3BP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1660661 | Sphingolipid de novo biosynthesis |
| reactome | R-HSA-428157 | Sphingolipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| wikipathways | WP1422 | Sphingolipid Metabolism |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD652 | UNC0638 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD375 | GW-405833 | 6 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD351 | GW843682X | 5 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD887 | Compound 23 citrate | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in COL4A3BP
CLASSFICATION
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