PKN2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase N2 | MIM:602549 | Ensembl:ENSG00000065243 | HGNC:HGNC:9406 | PA33770 | 1p22.2 |
GO terms in PKN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | IDA | GO:0030496 | midbody |
| CC | IDA | GO:0032154 | cleavage furrow |
| CC | IEA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0043296 | apical junction complex |
| CC | IDA | GO:0045111 | intermediate filament cytoskeleton |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IDA | GO:0010631 | epithelial cell migration |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IEA | GO:0030030 | cell projection organization |
| BP | IMP | GO:0032467 | positive regulation of cytokinesis |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0043297 | apical junction assembly |
| BP | IMP | GO:0045070 | positive regulation of viral genome replication |
| BP | IMP | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IEA | GO:0051301 | cell division |
| BP | IMP | GO:2000145 | regulation of cell motility |
| MF | HDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004697 | protein kinase C activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | IEA | GO:0017049 | GTP-Rho binding |
| MF | IDA | GO:0042826 | histone deacetylase binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IPI | GO:0070063 | RNA polymerase binding |
Gene expression in normal tissue: PKN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PKN2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-5625740 | RHO GTPases activate PKNs |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| pid | rhoa_pathway | RhoA signaling pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD375 | GW-405833 | 6 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD201 | SKI II | 4 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD289 | Parthenolide | 9 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD322 | FK 866 | 6 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD424 | Tamatinib | 6 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD49 | Mitomycin | 2 |
| iGMDRD314 | Tanespimycin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PKN2
CLASSFICATION
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