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LTK

Summary: The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
leukocyte receptor tyrosine kinase	MIM:151520	Ensembl:ENSG00000062524	HGNC:HGNC:6721	PA30483	15q15.1

Gene Categories:

TYROSINE KINASE DRUGGABLE GENOME KINASE

GO terms in LTK

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0004672	protein kinase activity
MF	IBA	GO:0004709	MAP kinase kinase kinase activity
MF	IBA	GO:0004713	protein tyrosine kinase activity
MF	TAS	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	IEA	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	IBA	GO:0004888	transmembrane signaling receptor activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IBA	GO:0031434	mitogen-activated protein kinase kinase binding
CC	IEA	GO:0005622	intracellular
CC	IBA	GO:0005737	cytoplasm
CC	TAS	GO:0005886	plasma membrane
CC	IBA	GO:0005887	integral component of plasma membrane
CC	TAS	GO:0005887	integral component of plasma membrane
CC	IDA	GO:0016020	membrane
CC	IBA	GO:0043235	receptor complex
BP	IBA	GO:0001934	positive regulation of protein phosphorylation
BP	IDA	GO:0006468	protein phosphorylation
BP	TAS	GO:0007165	signal transduction
BP	IEA	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
BP	IBA	GO:0007275	multicellular organism development
BP	IDA	GO:0008283	cell proliferation
BP	IBA	GO:0009968	negative regulation of signal transduction
BP	IDA	GO:0010666	positive regulation of cardiac muscle cell apoptotic process
BP	IMP	GO:0010976	positive regulation of neuron projection development
BP	IMP	GO:0014065	phosphatidylinositol 3-kinase signaling
BP	IEA	GO:0018108	peptidyl-tyrosine phosphorylation
BP	IBA	GO:0030154	cell differentiation
BP	IBA	GO:0033674	positive regulation of kinase activity
BP	IBA	GO:0043066	negative regulation of apoptotic process
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	IBA	GO:0070374	positive regulation of ERK1 and ERK2 cascade
BP	IMP	GO:0071300	cellular response to retinoic acid

Gene expression in normal tissue: LTK

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LTK

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD546	BMS-754807	2
iGMDRD427	ABT737	2
iGMDRD494	Neopeltolide	4
iGMDRD126	Tipifarnib	2
iGMDRD889	Compound 7d-cis	2
iGMDRD772	BRD4770	2
iGMDRD420	Leucascandrolide A	2
iGMDRD1008	SR-II-138A	2
iGMDRD579	PF750	5
iGMDRD466	Chaetocin	3
iGMDRD634	SCHEMBL2608041	3
iGMDRD375	GW-405833	5
iGMDRD446	LY 2183240	2
iGMDRD201	SKI II	3
iGMDRD193	Fqi1	3
iGMDRD885	Compound 110	3
iGMDRD52	Rotenone	2
iGMDRD270	Ciclosporin	2
iGMDRD802	4-methylfasudil	5
iGMDRD64	Parbendazole	4
iGMDRD268	Cerulenin	2
iGMDRD23	Gossypol	2
iGMDRD524	ISX-9	2
iGMDRD188	Piperlongumine	2
iGMDRD100	Zebularine	2
iGMDRD74	Idarubicin	2
iGMDRD887	Compound 23 citrate	2
iGMDRD888	Compound 44	1
iGMDRD577	BIX01294	5
iGMDRD506	Fedratinib	7
iGMDRD562	Navitoclax	4
iGMDRD424	Tamatinib	1
iGMDRD652	UNC0638	2
iGMDRD79	Gemcitabine	5
iGMDRD901	ELCPK	3
iGMDRD123	Isoevodiamine	2
iGMDRD154	NSC23766	3
iGMDRD314	Tanespimycin	2
iGMDRD221	Tamoxifen	3
iGMDRD481	Dactolisib	3
iGMDRD77	Itraconazole	5
iGMDRD213	SMR000068650	1
iGMDRD137	Indisulam	4
iGMDRD300	Tozasertib	3
iGMDRD505	Pevonedistat	2
iGMDRD246	NPC26	2
iGMDRD286	Nsc 632839	3
iGMDRD367	Ro 28-1675	3
iGMDRD872	BRD7137	2
iGMDRD329	Merck60	2
iGMDRD269	Purmorphamine	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LTK

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.