KPNA5
Summary: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| karyopherin subunit alpha 5 | MIM:604545 | Ensembl:ENSG00000196911 | HGNC:HGNC:6398 | PA30189 | 6q22.1 |
Gene Categories:
TRANSPORTERGO terms in KPNA5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005643 | nuclear pore |
| CC | IBA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IBA | GO:0006607 | NLS-bearing protein import into nucleus |
| BP | TAS | GO:0006607 | NLS-bearing protein import into nucleus |
| BP | TAS | GO:0019054 | modulation by virus of host process |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008139 | nuclear localization sequence binding |
| MF | IBA | GO:0008565 | protein transporter activity |
| MF | IEA | GO:0061608 | nuclear import signal receptor activity |
Gene expression in normal tissue: KPNA5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KPNA5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168253 | Host Interactions with Influenza Factors |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168276 | NS1 Mediated Effects on Host Pathways |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-913531 | Interferon Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD255 | SB225002 | 7 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD474 | Avrainvillamide | 10 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD427 | ABT737 | 9 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD886 | Compound 1541A | 4 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD267 | Oligomycin A | 5 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD48 | Dexamethasone | 2 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KPNA5
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