iGMDRD93

Canonical SMILES: C1=CN=C(N=C1N)N

InChI: InChI=1S/C4H6N4/c5-3-1-2-7-4(6)8-3/h1-2H,(H4,5,6,7,8)

InChI Key: YAAWASYJIRZXSZ-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard Name2,4-Pyrimidinediamine
Pubchem CID67431
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 2

Drug-gene pathway enrichments

1wikipathways: MET in type 1 papillary renal cell carcinoma1wikipathways: Differentiation Pathway1kegg: Non-small cell lung cancer - Homo sapiens (human)1kegg: Pathways in cancer - Homo sapiens (human)

Drug-gene GO enrichments

3CC: integral component of plasma membrane3MF: transmembrane receptor protein tyrosine kinase activity2BP: phosphorylation2MF: protein tyrosine kinase activity2BP: protein autophosphorylation1BP: positive regulation of kinase activity1BP: NIK/NF-kappaB signaling1BP: swimming behavior1BP: hippocampus development1BP: peptidyl-tyrosine phosphorylation

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
238 ALK 2
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Gene in drug-gene network: Network Plot

17-DMAG17-DMAGPF-2341066PF-2341066PX 12PX 12CeritinibCeritinibnavitoclaxnavitoclaxTAE-684TAE-684ParthenolideParthenolideTamoxifenTamoxifenSCH-529074SCH-529074itraconazoleitraconazoleSB225002SB225002bistramide Abistramide AlorlatiniblorlatinibgossypolgossypolCH5424802CH5424802zebularinezebularineursolic acidursolic acidBrigatinibBrigatinibALKALK2,4-pyrimidinediamine2,4-pyrimidinediamine

Models in 2,4-Pyrimidinediamine

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
FUS(EML4-ALK)&SNV(ALK E6del) gene 18593892 LUNG Non-Small Cell Lung Cancer (NSCLC) 2,4-pyrimidinediamine sensitivity in vivo
SNV(ALK A20del) gene 18593892 LUNG Non-Small Cell Lung Cancer (NSCLC) 2,4-pyrimidinediamine sensitivity in vivo
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