ST6GALNAC5

Summary: The protein encoded by this gene is a Golgi type II transmembrane glycosyltransferase. The encoded protein catalyzes the transfer of sialic acid to cell surface proteins to modulate cell-cell interactions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
OMIM IDMIM:610134
Ensembl IDEnsembl:ENSG00000117069
HGNC IDHGNC:HGNC:19342
PHARMGKB IDPA134924485
Map Location1p31.1

GO terms in ST6GALNAC5


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
MF TAS GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
MF IBA GO:0008373 sialyltransferase activity
MF ISS GO:0008373 sialyltransferase activity
BP ISS GO:0006688 glycosphingolipid biosynthetic process
BP IBA GO:0009311 oligosaccharide metabolic process
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Gene expression in normal tissue: ST6GALNAC5

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 4

Gene-drug pathway distribution

ERK MAPK signaling2Protein stability and degradation1RTK signaling1

Pathways in ST6GALNAC5


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Database
Pathway ID
Pathway Des.
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-4085001 Sialic acid metabolism
reactome R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
reactome R-HSA-446203 Asparagine N-linked glycosylation
reactome R-HSA-446219 Synthesis of substrates in N-glycan biosythesis
reactome R-HSA-597592 Post-translational protein modification
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 1
iGMDRD456 Crizotinib 1
iGMDRD309 17AAG 1
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ST6GALNAC5

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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