TYRO3
Summary: The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TYRO3 protein tyrosine kinase | MIM:600341 | Ensembl:ENSG00000092445 | HGNC:HGNC:12446 | PA37097 | 15q15.1 |
GO terms in TYRO3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ISS | GO:0005634 | nucleus |
| CC | ISS | GO:0005635 | nuclear envelope |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | NAS | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IBA | GO:0043235 | receptor complex |
| BP | IEA | GO:0001779 | natural killer cell differentiation |
| BP | NAS | GO:0007155 | cell adhesion |
| BP | NAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007218 | neuropeptide signaling pathway |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | ISS | GO:0007283 | spermatogenesis |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | NAS | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | IBA | GO:0016055 | Wnt signaling pathway |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0021885 | forebrain cell migration |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | ISS | GO:0030168 | platelet activation |
| BP | ISS | GO:0032940 | secretion by cell |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | ISS | GO:0034122 | negative regulation of toll-like receptor signaling pathway |
| BP | ISS | GO:0034446 | substrate adhesion-dependent cell spreading |
| BP | ISS | GO:0042698 | ovulation cycle |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043277 | apoptotic cell clearance |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | ISS | GO:0043491 | protein kinase B signaling |
| BP | ISS | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | ISS | GO:0045824 | negative regulation of innate immune response |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | ISS | GO:0050728 | negative regulation of inflammatory response |
| BP | IEA | GO:0051250 | negative regulation of lymphocyte activation |
| BP | IEA | GO:0060068 | vagina development |
| BP | ISS | GO:0070050 | neuron cellular homeostasis |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | ISS | GO:0070527 | platelet aggregation |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | NAS | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0017147 | Wnt-protein binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IPI | GO:0043548 | phosphatidylinositol 3-kinase binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: TYRO3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TYRO3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD851 | BRD-K34222889 | 1 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD133 | Lapatinib | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD94 | Narciclasine | 1 |
| iGMDRD474 | Avrainvillamide | 9 |
| iGMDRD647 | StemRegenin 1 | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD890 | CR.1.31B | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD623 | BRD-K52037352 | 1 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD222 | HC-067047 | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD283 | Bosutinib | 1 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD508 | KU0063794 | 1 |
| iGMDRD119 | Temsirolimus | 1 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD871 | BRD6368 | 7 |
| iGMDRD526 | KX2-391 | 1 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD251 | ML162 | 1 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD186 | SMER3 | 1 |
| iGMDRD16 | CICLOPIROX | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD343 | MK-0752 | 1 |
| iGMDRD165 | Tretinoin | 1 |
| iGMDRD541 | SNX-2112 (PF-04928473) | 1 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD50 | Cytarabine | 1 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD594 | AZD-8055 | 1 |
| iGMDRD703 | KPT185 | 1 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD761 | KHS101 | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD444 | Tivantinib | 1 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD677 | ABT-199 (GDC-0199) | 1 |
| iGMDRD533 | HSCI1_000270 | 1 |
| iGMDRD862 | BRD-K94991378 | 1 |
| iGMDRD613 | CHEMBL258148 | 1 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD320 | PIK-93 | 1 |
| iGMDRD1037 | X1S.3R.RSL.3 | 1 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD261 | OSI-027 | 1 |
| iGMDRD723 | MI-2 | 1 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD697 | Methylstat | 1 |
| iGMDRD591 | PF-3758309 | 1 |
| iGMDRD579 | PF750 | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD144 | NSC95397 | 1 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD477 | AT13387 | 1 |
| iGMDRD990 | PL.DI | 1 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD157 | Ouabain | 1 |
| iGMDRD208 | Necrosulfonamide | 1 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD582 | MLN 2238 | 1 |
| iGMDRD178 | MG-132 | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD36 | Phloretin | 1 |
| iGMDRD843 | BRD-A86708339 | 1 |
| iGMDRD831 | BCL.LZH.4 | 1 |
| iGMDRD858 | BRD-K71935468 | 1 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD307 | Manumycin A | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TYRO3
CLASSFICATION
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