TYRO3


Summary: The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TYRO3 protein tyrosine kinaseMIM:600341Ensembl:ENSG00000092445HGNC:HGNC:12446PA3709715q15.1

GO terms in TYRO3


Term TypeEvidence TypeGO Term IDGO Des.
CCISSGO:0005634nucleus
CCISSGO:0005635nuclear envelope
CCIBAGO:0005737cytoplasm
CCISSGO:0005789endoplasmic reticulum membrane
CCIBAGO:0005887integral component of plasma membrane
CCNASGO:0005887integral component of plasma membrane
CCIDAGO:0009986cell surface
CCIBAGO:0043235receptor complex
BPIEAGO:0001779natural killer cell differentiation
BPNASGO:0007155cell adhesion
BPNASGO:0007165signal transduction
BPIEAGO:0007218neuropeptide signaling pathway
BPIBAGO:0007275multicellular organism development
BPISSGO:0007283spermatogenesis
BPIBAGO:0009968negative regulation of signal transduction
BPNASGO:0014065phosphatidylinositol 3-kinase signaling
BPIBAGO:0016055Wnt signaling pathway
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPISSGO:0021885forebrain cell migration
BPIBAGO:0030154cell differentiation
BPISSGO:0030168platelet activation
BPISSGO:0032940secretion by cell
BPIBAGO:0033674positive regulation of kinase activity
BPISSGO:0034122negative regulation of toll-like receptor signaling pathway
BPISSGO:0034446substrate adhesion-dependent cell spreading
BPISSGO:0042698ovulation cycle
BPIBAGO:0043066negative regulation of apoptotic process
BPISSGO:0043277apoptotic cell clearance
BPIBAGO:0043410positive regulation of MAPK cascade
BPISSGO:0043491protein kinase B signaling
BPISSGO:0043524negative regulation of neuron apoptotic process
BPISSGO:0045824negative regulation of innate immune response
BPIEAGO:0046718viral entry into host cell
BPIDAGO:0046777protein autophosphorylation
BPISSGO:0050728negative regulation of inflammatory response
BPIEAGO:0051250negative regulation of lymphocyte activation
BPIEAGO:0060068vagina development
BPISSGO:0070050neuron cellular homeostasis
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPISSGO:0070527platelet aggregation
MFIEAGO:0001618virus receptor activity
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIDAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFNASGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0017147Wnt-protein binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIPIGO:0043548phosphatidylinositol 3-kinase binding
MFIEAGO:0046982protein heterodimerization activity

Gene expression in normal tissue: TYRO3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TYRO3


DatabasePathway IDPathway Des.
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4217Ebola Virus Pathway on Host

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD851BRD-K342228891
iGMDRD506Fedratinib3
iGMDRD188Piperlongumine3
iGMDRD133Lapatinib1
iGMDRD23Gossypol3
iGMDRD94Narciclasine1
iGMDRD474Avrainvillamide9
iGMDRD647StemRegenin 11
iGMDRD117Docetaxel1
iGMDRD61Kinetin riboside3
iGMDRD890CR.1.31B1
iGMDRD316N9-Isopropyl-olomoucine1
iGMDRD623BRD-K520373521
iGMDRD425ERASTIN1
iGMDRD222HC-0670471
iGMDRD151CHM-13
iGMDRD126Tipifarnib3
iGMDRD781Sirolimus2
iGMDRD283Bosutinib1
iGMDRD670ML 2101
iGMDRD366PI-1031
iGMDRD329Merck601
iGMDRD508KU00637941
iGMDRD119Temsirolimus1
iGMDRD286Nsc 6328391
iGMDRD871BRD63687
iGMDRD526KX2-3911
iGMDRD147Prima-11
iGMDRD251ML1621
iGMDRD121GMX17783
iGMDRD186SMER31
iGMDRD16CICLOPIROX1
iGMDRD705Nakiterpiosin3
iGMDRD289Parthenolide1
iGMDRD343MK-07521
iGMDRD165Tretinoin1
iGMDRD541SNX-2112 (PF-04928473)1
iGMDRD154NSC237661
iGMDRD79Gemcitabine2
iGMDRD50Cytarabine1
iGMDRD523Cyanoquinoline, 113
iGMDRD594AZD-80551
iGMDRD703KPT1851
iGMDRD560MK-22061
iGMDRD532Olaparib1
iGMDRD562Navitoclax3
iGMDRD398Sepantronium1
iGMDRD887Compound 23 citrate2
iGMDRD100Zebularine3
iGMDRD761KHS1011
iGMDRD451Serdemetan3
iGMDRD444Tivantinib1
iGMDRD268Cerulenin1
iGMDRD677ABT-199 (GDC-0199)1
iGMDRD533HSCI1_0002701
iGMDRD862BRD-K949913781
iGMDRD613CHEMBL2581481
iGMDRD138PX 121
iGMDRD320PIK-931
iGMDRD1037X1S.3R.RSL.31
iGMDRD318PAC-13
iGMDRD261OSI-0271
iGMDRD723MI-21
iGMDRD608Refametinib1
iGMDRD697Methylstat1
iGMDRD591PF-37583091
iGMDRD579PF7501
iGMDRD387CHIR-990211
iGMDRD144NSC953971
iGMDRD872BRD71373
iGMDRD414MST-3121
iGMDRD477AT133871
iGMDRD990PL.DI1
iGMDRD886Compound 1541A3
iGMDRD157Ouabain1
iGMDRD208Necrosulfonamide1
iGMDRD271Brefeldin A1
iGMDRD267Oligomycin A1
iGMDRD481Dactolisib2
iGMDRD582MLN 22381
iGMDRD178MG-1321
iGMDRD351GW843682X3
iGMDRD36Phloretin1
iGMDRD843BRD-A867083391
iGMDRD831BCL.LZH.41
iGMDRD858BRD-K719354681
iGMDRD486Tosedostat1
iGMDRD307Manumycin A1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TYRO3

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