FCGR1B
Summary: Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Fc fragment of IgG receptor Ib | MIM:601502 | Ensembl:ENSG00000198019 | HGNC:HGNC:3614 | PA28061 | 1p11.2 |
GO terms in FCGR1B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0019763 | immunoglobulin receptor activity |
| MF | IEA | GO:0019864 | IgG binding |
| CC | NAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0030669 | clathrin-coated endocytic vesicle membrane |
| CC | TAS | GO:0031901 | early endosome membrane |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | TAS | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| BP | TAS | GO:0006898 | receptor-mediated endocytosis |
| BP | NAS | GO:0006955 | immune response |
| BP | IEA | GO:0038093 | Fc receptor signaling pathway |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
Gene expression in normal tissue: FCGR1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FCGR1B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) |
| reactome | R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD608 | Refametinib | 1 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD574 | Ruxolitinib | 1 |
| iGMDRD1037 | X1S.3R.RSL.3 | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD186 | SMER3 | 1 |
| iGMDRD251 | ML162 | 1 |
| iGMDRD208 | Necrosulfonamide | 1 |
| iGMDRD12 | Bicalutamide | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FCGR1B
CLASSFICATION
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