FCGR1B

Summary: Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameFc fragment of IgG receptor Ib
OMIM IDMIM:601502
Ensembl IDEnsembl:ENSG00000198019
HGNC IDHGNC:HGNC:3614
PHARMGKB IDPA28061
Map Location1p11.2

GO terms in FCGR1B


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF NAS GO:0019763 immunoglobulin receptor activity
MF IEA GO:0019864 IgG binding
CC NAS GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
CC IEA GO:0016021 integral component of membrane
CC TAS GO:0030669 clathrin-coated endocytic vesicle membrane
Showing 1 to 6 of 13 rows rows per page

Gene expression in normal tissue: FCGR1B

Gene-model tissue-cancer distribution: Bubble Plot

SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 11

Gene-drug pathway distribution

undefined5ERK MAPK signaling2IGFR signaling2Prostate cancer1Other, kinases1Proteasome1

Pathways in FCGR1B


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-1236975 Antigen processing-Cross presentation
reactome R-HSA-1236975 Antigen processing-Cross presentation
reactome R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
reactome R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-1280218 Adaptive Immune System
Showing 1 to 6 of 13 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD608 Refametinib 1
iGMDRD152 179324-69-7 1
iGMDRD352 PD-0325901 1
iGMDRD670 ML 210 1
Showing 1 to 4 of 12 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FCGR1B

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.