CIC


Summary: The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
capicua transcriptional repressorMIM:612082Ensembl:ENSG00000079432HGNC:HGNC:14214PA2651319q13.2

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in CIC


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIEAGO:0032991protein-containing complex
CCIDAGO:0043231intracellular membrane-bounded organelle
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPISSGO:0007420brain development
BPISSGO:0007612learning
BPISSGO:0007613memory
BPISSGO:0035176social behavior
BPISSGO:0045892negative regulation of transcription, DNA-templated
BPIEAGO:0048286lung alveolus development
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
MFIEAGO:0003682chromatin binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: CIC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CIC


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD150RITA7
iGMDRD405PIK-753
iGMDRD48Dexamethasone1
iGMDRD512nutlin 31
iGMDRD177Teniposide3
iGMDRD341Triacsin c4
iGMDRD698Neratinib3
iGMDRD434BMS-5369244
iGMDRD77Itraconazole3
iGMDRD137Indisulam3
iGMDRD147Prima-11
iGMDRD505Pevonedistat2
iGMDRD322FK 8663
iGMDRD82Quiflapon3
iGMDRD872BRD71372
iGMDRD414MST-3122
iGMDRD286Nsc 6328391
iGMDRD871BRD63682
iGMDRD144NSC953972
iGMDRD781Sirolimus8
iGMDRD494Neopeltolide3
iGMDRD126Tipifarnib6
iGMDRD420Leucascandrolide A3
iGMDRD889Compound 7d-cis2
iGMDRD280CYTOCHALASIN B3
iGMDRD679Bistramide A7
iGMDRD466Chaetocin3
iGMDRD297Austocystin D1
iGMDRD470Trametinib1
iGMDRD375GW-4058333
iGMDRD71Sparfosic acid3
iGMDRD608Refametinib1
iGMDRD446LY 21832403
iGMDRD61Kinetin riboside4
iGMDRD171Pemetrexed1
iGMDRD870BRD636101
iGMDRD513BML-2593
iGMDRD270Ciclosporin3
iGMDRD255SB2250022
iGMDRD64Parbendazole1
iGMDRD524ISX-93
iGMDRD356PNU-746543
iGMDRD399Selumetinib3
iGMDRD74Idarubicin2
iGMDRD887Compound 23 citrate3
iGMDRD100Zebularine3
iGMDRD188Piperlongumine2
iGMDRD780PP-302
iGMDRD398Sepantronium2
iGMDRD562Navitoclax6
iGMDRD577BIX012942

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CIC

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