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IRS1

Summary: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
insulin receptor substrate 1	MIM:147545	Ensembl:ENSG00000169047	HGNC:HGNC:6125	PA203	2q36.3

Gene Categories:

LIPID KINASE CLINICALLY ACTIONABLE KINASE

GO terms in IRS1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0001784	phosphotyrosine residue binding
MF	ISS	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
MF	ISS	GO:0005080	protein kinase C binding
MF	TAS	GO:0005088	Ras guanyl-nucleotide exchange factor activity
MF	IBA	GO:0005158	insulin receptor binding
MF	IPI	GO:0005158	insulin receptor binding
MF	IPI	GO:0005159	insulin-like growth factor receptor binding
MF	IPI	GO:0005515	protein binding
MF	TAS	GO:0016303	1-phosphatidylinositol-3-kinase activity
MF	ISS	GO:0042169	SH2 domain binding
MF	IBA	GO:0043548	phosphatidylinositol 3-kinase binding
MF	IPI	GO:0043548	phosphatidylinositol 3-kinase binding
MF	ISS	GO:0043548	phosphatidylinositol 3-kinase binding
MF	TAS	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
CC	IDA	GO:0005634	nucleus
CC	ISS	GO:0005634	nucleus
CC	ISS	GO:0005737	cytoplasm
CC	IBA	GO:0005829	cytosol
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IBA	GO:0005886	plasma membrane
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	ISS	GO:0005899	insulin receptor complex
CC	IDA	GO:0005901	caveola
CC	ISS	GO:0043231	intracellular membrane-bounded organelle
BP	TAS	GO:0000165	MAPK cascade
BP	TAS	GO:0007165	signal transduction
BP	NAS	GO:0008284	positive regulation of cell proliferation
BP	IBA	GO:0008286	insulin receptor signaling pathway
BP	IDA	GO:0008286	insulin receptor signaling pathway
BP	IMP	GO:0008286	insulin receptor signaling pathway
BP	IPI	GO:0008286	insulin receptor signaling pathway
BP	IMP	GO:0010907	positive regulation of glucose metabolic process
BP	IDA	GO:0014065	phosphatidylinositol 3-kinase signaling
BP	IBA	GO:0019216	regulation of lipid metabolic process
BP	IMP	GO:0032000	positive regulation of fatty acid beta-oxidation
BP	IDA	GO:0032868	response to insulin
BP	IMP	GO:0032869	cellular response to insulin stimulus
BP	IEA	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
BP	TAS	GO:0038111	interleukin-7-mediated signaling pathway
BP	TAS	GO:0042593	glucose homeostasis
BP	ISS	GO:0043434	response to peptide hormone
BP	ISS	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
BP	IMP	GO:0045725	positive regulation of glycogen biosynthetic process
BP	NAS	GO:0045725	positive regulation of glycogen biosynthetic process
BP	IMP	GO:0046326	positive regulation of glucose import
BP	ISS	GO:0046627	negative regulation of insulin receptor signaling pathway
BP	ISS	GO:0046628	positive regulation of insulin receptor signaling pathway
BP	IDA	GO:0046676	negative regulation of insulin secretion
BP	IEA	GO:0046854	phosphatidylinositol phosphorylation
BP	IPI	GO:0048009	insulin-like growth factor receptor signaling pathway
BP	TAS	GO:0048015	phosphatidylinositol-mediated signaling
BP	TAS	GO:0051897	positive regulation of protein kinase B signaling
BP	IDA	GO:2001275	positive regulation of glucose import in response to insulin stimulus

Gene expression in normal tissue: IRS1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IRS1

Database	Pathway ID	Pathway Des.
kegg	hsa04022	cGMP-PKG signaling pathway - Homo sapiens (human)
kegg	hsa04068	FoxO signaling pathway - Homo sapiens (human)
kegg	hsa04140	Autophagy - animal - Homo sapiens (human)
kegg	hsa04150	mTOR signaling pathway - Homo sapiens (human)
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa04152	AMPK signaling pathway - Homo sapiens (human)
kegg	hsa04211	Longevity regulating pathway - Homo sapiens (human)
kegg	hsa04213	Longevity regulating pathway - multiple species - Homo sapiens (human)
kegg	hsa04722	Neurotrophin signaling pathway - Homo sapiens (human)
kegg	hsa04910	Insulin signaling pathway - Homo sapiens (human)
kegg	hsa04920	Adipocytokine signaling pathway - Homo sapiens (human)
kegg	hsa04923	Regulation of lipolysis in adipocytes - Homo sapiens (human)
kegg	hsa04930	Type II diabetes mellitus - Homo sapiens (human)
kegg	hsa04931	Insulin resistance - Homo sapiens (human)
kegg	hsa04932	Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegg	hsa04960	Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
kegg	hsa05206	MicroRNAs in cancer - Homo sapiens (human)
netpath	Pathway_Alpha6Beta4Integrin	Alpha6Beta4Integrin
netpath	Pathway_BDNF	BDNF
netpath	Pathway_Ghrelin	Ghrelin
netpath	Pathway_IL-7	IL-7
netpath	Pathway_IL2	IL2
netpath	Pathway_IL4	IL4
netpath	Pathway_Leptin	Leptin
netpath	Pathway_Oncostatin_M	Oncostatin_M
netpath	Pathway_TNFalpha	TNFalpha
biocarta	eif4pathway	regulation of eif-4e and p70s6 kinase
biocarta	ghpathway	growth hormone signaling pathway
biocarta	igf1pathway	igf-1 signaling pathway
biocarta	igf1rpathway	multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation
biocarta	il2rbpathway	il-2 receptor beta chain in t cell activation
biocarta	insulinpathway	insulin signaling pathway
biocarta	longevitypathway	the igf-1 receptor and longevity
biocarta	mtorpathway	mtor signaling pathway
reactome	R-HSA-109704	PI3K Cascade
reactome	R-HSA-112399	IRS-mediated signalling
reactome	R-HSA-112399	IRS-mediated signalling
reactome	R-HSA-112412	SOS-mediated signalling
reactome	R-HSA-112412	SOS-mediated signalling
reactome	R-HSA-1257604	PIP3 activates AKT signaling
reactome	R-HSA-1266695	Interleukin-7 signaling
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1643685	Disease
reactome	R-HSA-166520	Signaling by NTRKs
reactome	R-HSA-166520	Signaling by NTRKs
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-187037	Signaling by NTRK1 (TRKA)
reactome	R-HSA-187037	Signaling by NTRK1 (TRKA)
reactome	R-HSA-198203	PI3K/AKT activation
reactome	R-HSA-198203	PI3K/AKT activation
reactome	R-HSA-199418	Negative regulation of the PI3K/AKT network
reactome	R-HSA-2219528	PI3K/AKT Signaling in Cancer
reactome	R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer
reactome	R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactome	R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactome	R-HSA-2428924	IGF1R signaling cascade
reactome	R-HSA-2428924	IGF1R signaling cascade
reactome	R-HSA-2428928	IRS-related events triggered by IGF1R
reactome	R-HSA-2428928	IRS-related events triggered by IGF1R
reactome	R-HSA-2586552	Signaling by Leptin
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-5663202	Diseases of signal transduction
reactome	R-HSA-5673001	RAF/MAP kinase cascade
reactome	R-HSA-5683057	MAPK family signaling cascades
reactome	R-HSA-5684996	MAPK1/MAPK3 signaling
reactome	R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactome	R-HSA-74713	IRS activation
reactome	R-HSA-74749	Signal attenuation
reactome	R-HSA-74751	Insulin receptor signalling cascade
reactome	R-HSA-74751	Insulin receptor signalling cascade
reactome	R-HSA-74752	Signaling by Insulin receptor
reactome	R-HSA-74752	Signaling by Insulin receptor
reactome	R-HSA-9006925	Intracellular signaling by second messengers
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
reactome	R-HSA-9034015	Signaling by NTRK3 (TRKC)
reactome	R-HSA-9603381	Activated NTRK3 signals through PI3K
reactome	R-HSA-982772	Growth hormone receptor signaling
smpdb	SMP00391	Insulin Signalling
smpdb	SMP00682	Leucine Stimulation on Insulin Signaling
wikipathways	WP1584	Type II diabetes mellitus
wikipathways	WP1984	Integrated Breast Cancer Pathway
wikipathways	WP2004	miR-targeted genes in lymphocytes - TarBase
wikipathways	WP2005	miR-targeted genes in muscle cell - TarBase
wikipathways	WP2034	Leptin signaling pathway
wikipathways	WP2037	Prolactin Signaling Pathway
wikipathways	WP2261	Signaling Pathways in Glioblastoma
wikipathways	WP2324	AGE-RAGE pathway
wikipathways	WP236	Adipogenesis
wikipathways	WP2374	Oncostatin M Signaling Pathway
wikipathways	WP2380	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathways	WP244	Alpha 6 Beta 4 signaling pathway
wikipathways	WP2512	Integrated Lung Cancer Pathway
wikipathways	WP2593	JAK-STAT
wikipathways	WP3599	Transcription factor regulation in adipogenesis
wikipathways	WP3850	Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling
wikipathways	WP3915	Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways	WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways	WP3935	Leptin Insulin Overlap
wikipathways	WP395	IL-4 Signaling Pathway
wikipathways	WP4172	PI3K-Akt Signaling Pathway
wikipathways	WP481	Insulin Signaling
wikipathways	WP581	EPO Receptor Signaling
wikipathways	WP585	Interferon type I signaling pathways
wikipathways	WP710	DNA Damage Response (only ATM dependent)
pharmgkb	PA153627758	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
pid	avb3_integrin_pathway	Integrins in angiogenesis
pid	igf1_pathway	IGF1 pathway
pid	il2_1pathway	IL2-mediated signaling events
pid	il4_2pathway	IL4-mediated signaling events
pid	insulin_pathway	Insulin Pathway
pid	mtor_4pathway	mTOR signaling pathway
pid	ptp1bpathway	Signaling events mediated by PTP1B
pid	ret_pathway	Signaling events regulated by Ret tyrosine kinase
pid	s1p_s1p2_pathway	S1P2 pathway
pid	shp2_pathway	SHP2 signaling

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD150	RITA	1
iGMDRD560	MK-2206	1
iGMDRD79	Gemcitabine	2
iGMDRD798	Ceranib-2	1
iGMDRD628	BRD-K55116708	1
iGMDRD512	nutlin 3	4
iGMDRD123	Isoevodiamine	2
iGMDRD211	(1S,3R)-RSL3	4
iGMDRD176	Decitabine	1
iGMDRD85	Ursolic acid	2
iGMDRD351	GW843682X	1
iGMDRD434	BMS-536924	3
iGMDRD705	Nakiterpiosin	2
iGMDRD6	AM-580	3
iGMDRD231	Importazole	1
iGMDRD267	Oligomycin A	3
iGMDRD77	Itraconazole	4
iGMDRD206	SJ-172550	1
iGMDRD121	GMX1778	2
iGMDRD103	SN-38	2
iGMDRD246	NPC26	4
iGMDRD872	BRD7137	2
iGMDRD871	BRD6368	3
iGMDRD367	Ro 28-1675	3
iGMDRD286	Nsc 632839	4
iGMDRD67	PENFLURIDOL	3
iGMDRD329	Merck60	2
iGMDRD670	ML 210	2
iGMDRD546	BMS-754807	1
iGMDRD779	PRL-3 Inhibitor I	2
iGMDRD462	OSI-906 (Linsitinib)	1
iGMDRD494	Neopeltolide	2
iGMDRD599	Salermide	3
iGMDRD466	Chaetocin	2
iGMDRD686	PF4708671	1
iGMDRD608	Refametinib	1
iGMDRD639	YK 4-279	2
iGMDRD171	Pemetrexed	2
iGMDRD870	BRD63610	5
iGMDRD441	TW 37	2
iGMDRD318	PAC-1	8
iGMDRD138	PX 12	2
iGMDRD513	BML-259	3
iGMDRD64	Parbendazole	2
iGMDRD60	Quinoclamine	5
iGMDRD356	PNU-74654	2
iGMDRD100	Zebularine	2
iGMDRD562	Navitoclax	5
iGMDRD398	Sepantronium	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IRS1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.