IRS1

Summary: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameinsulin receptor substrate 1
OMIM IDMIM:147545
Ensembl IDEnsembl:ENSG00000169047
HGNC IDHGNC:HGNC:6125
PHARMGKB IDPA203
Map Location2q36.3

GO terms in IRS1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0001784 phosphotyrosine residue binding
MF ISS GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
MF ISS GO:0005080 protein kinase C binding
MF TAS GO:0005088 Ras guanyl-nucleotide exchange factor activity
MF IBA GO:0005158 insulin receptor binding
MF IPI GO:0005158 insulin receptor binding
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Gene expression in normal tissue: IRS1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 30undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 61undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 16BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 3SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 3

Gene-drug pathway distribution

undefined34Apoptosis regulation4IGFR signaling2PI3K/MTOR signaling2One carbon pool by folate1ERK MAPK signaling1Cell cycle1Purine metabolism1Ferroptosis1MicroRNAs in cancer1

Pathways in IRS1


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Database
Pathway ID
Pathway Des.
kegg hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
kegg hsa04068 FoxO signaling pathway - Homo sapiens (human)
kegg hsa04140 Autophagy - animal - Homo sapiens (human)
kegg hsa04150 mTOR signaling pathway - Homo sapiens (human)
kegg hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
kegg hsa04152 AMPK signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD150 RITA 1
iGMDRD560 MK-2206 1
iGMDRD79 Gemcitabine 2
iGMDRD798 Ceranib-2 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IRS1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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