IRS1


Summary: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
insulin receptor substrate 1MIM:147545Ensembl:ENSG00000169047HGNC:HGNC:6125PA2032q36.3

GO terms in IRS1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0001784phosphotyrosine residue binding
MFISSGO:0005068transmembrane receptor protein tyrosine kinase adaptor activity
MFISSGO:0005080protein kinase C binding
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIBAGO:0005158insulin receptor binding
MFIPIGO:0005158insulin receptor binding
MFIPIGO:0005159insulin-like growth factor receptor binding
MFIPIGO:0005515protein binding
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFISSGO:0042169SH2 domain binding
MFIBAGO:0043548phosphatidylinositol 3-kinase binding
MFIPIGO:0043548phosphatidylinositol 3-kinase binding
MFISSGO:0043548phosphatidylinositol 3-kinase binding
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
CCIDAGO:0005634nucleus
CCISSGO:0005634nucleus
CCISSGO:0005737cytoplasm
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCISSGO:0005899insulin receptor complex
CCIDAGO:0005901caveola
CCISSGO:0043231intracellular membrane-bounded organelle
BPTASGO:0000165MAPK cascade
BPTASGO:0007165signal transduction
BPNASGO:0008284positive regulation of cell proliferation
BPIBAGO:0008286insulin receptor signaling pathway
BPIDAGO:0008286insulin receptor signaling pathway
BPIMPGO:0008286insulin receptor signaling pathway
BPIPIGO:0008286insulin receptor signaling pathway
BPIMPGO:0010907positive regulation of glucose metabolic process
BPIDAGO:0014065phosphatidylinositol 3-kinase signaling
BPIBAGO:0019216regulation of lipid metabolic process
BPIMPGO:0032000positive regulation of fatty acid beta-oxidation
BPIDAGO:0032868response to insulin
BPIMPGO:0032869cellular response to insulin stimulus
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPTASGO:0038111interleukin-7-mediated signaling pathway
BPTASGO:0042593glucose homeostasis
BPISSGO:0043434response to peptide hormone
BPISSGO:0043552positive regulation of phosphatidylinositol 3-kinase activity
BPIMPGO:0045725positive regulation of glycogen biosynthetic process
BPNASGO:0045725positive regulation of glycogen biosynthetic process
BPIMPGO:0046326positive regulation of glucose import
BPISSGO:0046627negative regulation of insulin receptor signaling pathway
BPISSGO:0046628positive regulation of insulin receptor signaling pathway
BPIDAGO:0046676negative regulation of insulin secretion
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPIPIGO:0048009insulin-like growth factor receptor signaling pathway
BPTASGO:0048015phosphatidylinositol-mediated signaling
BPTASGO:0051897positive regulation of protein kinase B signaling
BPIDAGO:2001275positive regulation of glucose import in response to insulin stimulus

Gene expression in normal tissue: IRS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IRS1


DatabasePathway IDPathway Des.
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04923Regulation of lipolysis in adipocytes - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04960Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_BDNFBDNF
netpathPathway_GhrelinGhrelin
netpathPathway_IL-7IL-7
netpathPathway_IL2IL2
netpathPathway_IL4IL4
netpathPathway_LeptinLeptin
netpathPathway_Oncostatin_MOncostatin_M
netpathPathway_TNFalphaTNFalpha
biocartaeif4pathwayregulation of eif-4e and p70s6 kinase
biocartaghpathwaygrowth hormone signaling pathway
biocartaigf1pathwayigf-1 signaling pathway
biocartaigf1rpathwaymultiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartainsulinpathwayinsulin signaling pathway
biocartalongevitypathwaythe igf-1 receptor and longevity
biocartamtorpathwaymtor signaling pathway
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-112412SOS-mediated signalling
reactomeR-HSA-112412SOS-mediated signalling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-198203PI3K/AKT activation
reactomeR-HSA-198203PI3K/AKT activation
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2586552Signaling by Leptin
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-74713IRS activation
reactomeR-HSA-74749Signal attenuation
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9034015Signaling by NTRK3 (TRKC)
reactomeR-HSA-9603381Activated NTRK3 signals through PI3K
reactomeR-HSA-982772Growth hormone receptor signaling
smpdbSMP00391Insulin Signalling
smpdbSMP00682Leucine Stimulation on Insulin Signaling
wikipathwaysWP1584Type II diabetes mellitus
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP236Adipogenesis
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP244Alpha 6 Beta 4 signaling pathway
wikipathwaysWP2512Integrated Lung Cancer Pathway
wikipathwaysWP2593JAK-STAT
wikipathwaysWP3599Transcription factor regulation in adipogenesis
wikipathwaysWP3850Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3935Leptin Insulin Overlap
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP581EPO Receptor Signaling
wikipathwaysWP585Interferon type I signaling pathways
wikipathwaysWP710DNA Damage Response (only ATM dependent)
pharmgkbPA153627758Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
pidavb3_integrin_pathwayIntegrins in angiogenesis
pidigf1_pathwayIGF1 pathway
pidil2_1pathwayIL2-mediated signaling events
pidil4_2pathwayIL4-mediated signaling events
pidinsulin_pathwayInsulin Pathway
pidmtor_4pathwaymTOR signaling pathway
pidptp1bpathwaySignaling events mediated by PTP1B
pidret_pathwaySignaling events regulated by Ret tyrosine kinase
pids1p_s1p2_pathwayS1P2 pathway
pidshp2_pathwaySHP2 signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD150RITA1
iGMDRD560MK-22061
iGMDRD79Gemcitabine2
iGMDRD798Ceranib-21
iGMDRD628BRD-K551167081
iGMDRD512nutlin 34
iGMDRD123Isoevodiamine2
iGMDRD211(1S,3R)-RSL34
iGMDRD176Decitabine1
iGMDRD85Ursolic acid2
iGMDRD351GW843682X1
iGMDRD434BMS-5369243
iGMDRD705Nakiterpiosin2
iGMDRD6AM-5803
iGMDRD231Importazole1
iGMDRD267Oligomycin A3
iGMDRD77Itraconazole4
iGMDRD206SJ-1725501
iGMDRD121GMX17782
iGMDRD103SN-382
iGMDRD246NPC264
iGMDRD872BRD71372
iGMDRD871BRD63683
iGMDRD367Ro 28-16753
iGMDRD286Nsc 6328394
iGMDRD67PENFLURIDOL3
iGMDRD329Merck602
iGMDRD670ML 2102
iGMDRD546BMS-7548071
iGMDRD779PRL-3 Inhibitor I2
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD494Neopeltolide2
iGMDRD599Salermide3
iGMDRD466Chaetocin2
iGMDRD686PF47086711
iGMDRD608Refametinib1
iGMDRD639YK 4-2792
iGMDRD171Pemetrexed2
iGMDRD870BRD636105
iGMDRD441TW 372
iGMDRD318PAC-18
iGMDRD138PX 122
iGMDRD513BML-2593
iGMDRD64Parbendazole2
iGMDRD60Quinoclamine5
iGMDRD356PNU-746542
iGMDRD100Zebularine2
iGMDRD562Navitoclax5
iGMDRD398Sepantronium2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IRS1

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