SMAD3

Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSMAD family member 3
OMIM IDMIM:603109
Ensembl IDEnsembl:ENSG00000166949
HGNC IDHGNC:HGNC:6769
PHARMGKB IDPA30526
Map Location15q22.33

GO terms in SMAD3


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding
MF IMP GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding
Showing 1 to 6 of 138 rows rows per page

Gene expression in normal tissue: SMAD3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined15ERK MAPK signaling3PI3K/MTOR signaling3JNK and p38 signaling1Genome integrity1Cytoskeleton1Stilbenoid, diarylheptanoid and gingerol biosynthesis1RTK signaling1Protein stability and degradation1DNA replication1

Pathways in SMAD3


Loading, please wait...
Database
Pathway ID
Pathway Des.
netpath Pathway_Alpha6Beta4Integrin Alpha6Beta4Integrin
netpath Pathway_AndrogenReceptor AndrogenReceptor
netpath Pathway_EGFR1 EGFR1
netpath Pathway_ID ID
netpath Pathway_TGF_beta_Receptor TGF_beta_Receptor
pid hif1_tfpathway HIF-1-alpha transcription factor network
Showing 1 to 6 of 107 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD608 Refametinib 1
iGMDRD686 PF4708671 1
iGMDRD634 SCHEMBL2608041 3
iGMDRD401 Afatinib 1
Showing 1 to 4 of 35 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMAD3

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.