SMAD3
Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SMAD family member 3 | MIM:603109 | Ensembl:ENSG00000166949 | HGNC:HGNC:6769 | PA30526 | 15q22.33 |
GO terms in SMAD3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding |
| MF | IMP | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding |
| MF | IDA | GO:0000987 | proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000989 | transcription factor activity, transcription factor binding |
| MF | IPI | GO:0001102 | RNA polymerase II activating transcription factor binding |
| MF | ISS | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005160 | transforming growth factor beta receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005518 | collagen binding |
| MF | IEA | GO:0008013 | beta-catenin binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0017151 | DEAD/H-box RNA helicase binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019902 | phosphatase binding |
| MF | IDA | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
| MF | IEA | GO:0031490 | chromatin DNA binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0031962 | mineralocorticoid receptor binding |
| MF | IPI | GO:0035259 | glucocorticoid receptor binding |
| MF | IC | GO:0035326 | enhancer binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0043130 | ubiquitin binding |
| MF | IPI | GO:0043425 | bHLH transcription factor binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0070410 | co-SMAD binding |
| MF | IPI | GO:0070412 | R-SMAD binding |
| MF | IPI | GO:0070878 | primary miRNA binding |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001657 | ureteric bud development |
| BP | IMP | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0001707 | mesoderm formation |
| BP | IEA | GO:0001756 | somitogenesis |
| BP | IEA | GO:0001889 | liver development |
| BP | IEA | GO:0001947 | heart looping |
| BP | IEA | GO:0002076 | osteoblast development |
| BP | IEA | GO:0002520 | immune system development |
| BP | IDA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IMP | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IMP | GO:0006955 | immune response |
| BP | IMP | GO:0007050 | cell cycle arrest |
| BP | IDA | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | TAS | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IDA | GO:0007183 | SMAD protein complex assembly |
| BP | IEA | GO:0007492 | endoderm development |
| BP | IEA | GO:0009880 | embryonic pattern specification |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0010694 | positive regulation of alkaline phosphatase activity |
| BP | IDA | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| BP | IMP | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| BP | IEA | GO:0016202 | regulation of striated muscle tissue development |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IMP | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| BP | IDA | GO:0019049 | evasion or tolerance of host defenses by virus |
| BP | IEA | GO:0023019 | signal transduction involved in regulation of gene expression |
| BP | IDA | GO:0030308 | negative regulation of cell growth |
| BP | IEA | GO:0030325 | adrenal gland development |
| BP | IEA | GO:0030335 | positive regulation of cell migration |
| BP | IEA | GO:0030501 | positive regulation of bone mineralization |
| BP | TAS | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | IEA | GO:0030878 | thyroid gland development |
| BP | TAS | GO:0031053 | primary miRNA processing |
| BP | IEA | GO:0032332 | positive regulation of chondrocyte differentiation |
| BP | IEA | GO:0032731 | positive regulation of interleukin-1 beta production |
| BP | IMP | GO:0032909 | regulation of transforming growth factor beta2 production |
| BP | IEA | GO:0032916 | positive regulation of transforming growth factor beta3 production |
| BP | IMP | GO:0032924 | activin receptor signaling pathway |
| BP | IEA | GO:0033689 | negative regulation of osteoblast proliferation |
| BP | IMP | GO:0038092 | nodal signaling pathway |
| BP | TAS | GO:0042060 | wound healing |
| BP | IEA | GO:0042110 | T cell activation |
| BP | IEA | GO:0042177 | negative regulation of protein catabolic process |
| BP | NAS | GO:0042307 | positive regulation of protein import into nucleus |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0045216 | cell-cell junction organization |
| BP | IDA | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| BP | IDA | GO:0045599 | negative regulation of fat cell differentiation |
| BP | IEA | GO:0045668 | negative regulation of osteoblast differentiation |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045930 | negative regulation of mitotic cell cycle |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048340 | paraxial mesoderm morphogenesis |
| BP | IEA | GO:0048589 | developmental growth |
| BP | IEA | GO:0048617 | embryonic foregut morphogenesis |
| BP | IEA | GO:0048701 | embryonic cranial skeleton morphogenesis |
| BP | IEA | GO:0050678 | regulation of epithelial cell proliferation |
| BP | IEA | GO:0050728 | negative regulation of inflammatory response |
| BP | IEA | GO:0050776 | regulation of immune response |
| BP | IEA | GO:0050821 | protein stabilization |
| BP | IEA | GO:0050927 | positive regulation of positive chemotaxis |
| BP | NAS | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0051098 | regulation of binding |
| BP | IDA | GO:0051481 | negative regulation of cytosolic calcium ion concentration |
| BP | IEA | GO:0051496 | positive regulation of stress fiber assembly |
| BP | IEA | GO:0051894 | positive regulation of focal adhesion assembly |
| BP | IEA | GO:0060039 | pericardium development |
| BP | IEA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IEA | GO:0060290 | transdifferentiation |
| BP | NAS | GO:0060395 | SMAD protein signal transduction |
| BP | IEA | GO:0061045 | negative regulation of wound healing |
| BP | IEA | GO:0061767 | negative regulation of lung blood pressure |
| BP | IEA | GO:0070306 | lens fiber cell differentiation |
| BP | TAS | GO:0071345 | cellular response to cytokine stimulus |
| BP | IDA | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| BP | IEA | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IEA | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| BP | IDA | GO:1901203 | positive regulation of extracellular matrix assembly |
| BP | IMP | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| BP | IEA | GO:1903243 | negative regulation of cardiac muscle hypertrophy in response to stress |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005637 | nuclear inner membrane |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IMP | GO:0043235 | receptor complex |
| CC | IDA | GO:0071141 | SMAD protein complex |
| CC | IDA | GO:0071144 | heteromeric SMAD protein complex |
Gene expression in normal tissue: SMAD3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SMAD3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_ID | ID |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| pid | smad2_3pathway | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| pid | telomerasepathway | Regulation of Telomerase |
| pid | tgfbrpathway | TGF-beta receptor signaling |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| kegg | hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2853 | Endoderm Differentiation |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP2870 | Extracellular vesicle-mediated signaling in recipient cells |
| wikipathways | WP34 | Ovarian Infertility Genes |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3668 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
| wikipathways | WP3850 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| wikipathways | WP3859 | TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition |
| wikipathways | WP3874 | Canonical and Non-Canonical TGF-B signaling |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| reactome | R-HSA-1181150 | Signaling by NODAL |
| reactome | R-HSA-1181150 | Signaling by NODAL |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1502540 | Signaling by Activin |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2173788 | Downregulation of TGF-beta receptor signaling |
| reactome | R-HSA-2173789 | TGF-beta receptor signaling activates SMADs |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| reactome | R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| reactome | R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| reactome | R-HSA-3304347 | Loss of Function of SMAD4 in Cancer |
| reactome | R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer |
| reactome | R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer |
| reactome | R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer |
| reactome | R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer |
| reactome | R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer |
| reactome | R-HSA-3656532 | TGFBR1 KD Mutants in Cancer |
| reactome | R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8941855 | RUNX3 regulates CDKN1A transcription |
| reactome | R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-9008059 | Interleukin-37 signaling |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription |
| biocarta | g1pathway | cell cycle: g1/s check point |
| biocarta | nthipathway | nfkb activation by nontypeable hemophilus influenzae |
| biocarta | tgfbpathway | tgf beta signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD608 | Refametinib | 1 |
| iGMDRD686 | PF4708671 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD401 | Afatinib | 1 |
| iGMDRD378 | ZM-447439 | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD654 | SL 0101-1 | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD129 | SB-216763 | 1 |
| iGMDRD354 | Midostaurin | 1 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD185 | DMOG | 1 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD1039 | X681640 | 1 |
| iGMDRD451 | Serdemetan | 6 |
| iGMDRD57 | Chloropentafluorobenzene | 6 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD605 | AZD6482 | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD531 | AZD2281 | 1 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD412 | VX-702 | 1 |
| iGMDRD384 | EHT-1864 | 1 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD551 | Ponatinib | 1 |
| iGMDRD215 | CCT007093 | 1 |
| iGMDRD434 | BMS-536924 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SMAD3
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.