TCF7L2
Summary: This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transcription factor 7 like 2 | MIM:602228 | Ensembl:ENSG00000148737 | HGNC:HGNC:11641 | PA36394 | 10q25.2-q25.3 |
GO terms in TCF7L2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0001568 | blood vessel development |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0007050 | cell cycle arrest |
| BP | TAS | GO:0007223 | Wnt signaling pathway, calcium modulating pathway |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | ISS | GO:0009749 | response to glucose |
| BP | IMP | GO:0010909 | positive regulation of heparan sulfate proteoglycan biosynthetic process |
| BP | IBA | GO:0016055 | Wnt signaling pathway |
| BP | TAS | GO:0031016 | pancreas development |
| BP | IMP | GO:0032024 | positive regulation of insulin secretion |
| BP | IDA | GO:0032092 | positive regulation of protein binding |
| BP | IDA | GO:0032350 | regulation of hormone metabolic process |
| BP | IDA | GO:0042593 | glucose homeostasis |
| BP | IDA | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IMP | GO:0043570 | maintenance of DNA repeat elements |
| BP | IMP | GO:0044334 | canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition |
| BP | IDA | GO:0045444 | fat cell differentiation |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0046827 | positive regulation of protein export from nucleus |
| BP | IDA | GO:0048625 | myoblast fate commitment |
| BP | IMP | GO:0048660 | regulation of smooth muscle cell proliferation |
| BP | IMP | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IBA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IC | GO:0060070 | canonical Wnt signaling pathway |
| BP | IMP | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | TAS | GO:1904837 | beta-catenin-TCF complex assembly |
| BP | ISS | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process |
| BP | ISS | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IEA | GO:0016605 | PML body |
| CC | IDA | GO:0032993 | protein-DNA complex |
| CC | IDA | GO:0070369 | beta-catenin-TCF7L2 complex |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IPI | GO:0001103 | RNA polymerase II repressing transcription factor binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008013 | beta-catenin binding |
| MF | IDA | GO:0008013 | beta-catenin binding |
| MF | IPI | GO:0008013 | beta-catenin binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0035257 | nuclear hormone receptor binding |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IMP | GO:0043565 | sequence-specific DNA binding |
| MF | IBA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IPI | GO:0045295 | gamma-catenin binding |
| MF | IPI | GO:0070016 | armadillo repeat domain binding |
Gene expression in normal tissue: TCF7L2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TCF7L2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2118 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP3678 | Amplification and Expansion of Oncogenic Pathways as Metastatic Traits |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| netpath | Pathway_ID | ID |
| netpath | Pathway_Wnt | Wnt |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
| kegg | hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| kegg | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2980736 | Peptide hormone metabolism |
| reactome | R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex |
| reactome | R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400508 | Incretin synthesis, secretion, and inactivation |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters |
| reactome | R-HSA-4641265 | Repression of WNT target genes |
| reactome | R-HSA-4641265 | Repression of WNT target genes |
| reactome | R-HSA-4791275 | Signaling by WNT in cancer |
| reactome | R-HSA-5339700 | TCF7L2 mutants don't bind CTBP |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8951430 | RUNX3 regulates WNT signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD660 | GSK-1070916 | 1 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD317 | CCT 018159 | 1 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD412 | VX-702 | 1 |
| iGMDRD353 | PD0325901 | 3 |
| iGMDRD556 | Quizartinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TCF7L2
CLASSFICATION
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