TCF7L2

Summary: This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametranscription factor 7 like 2
OMIM IDMIM:602228
Ensembl IDEnsembl:ENSG00000148737
HGNC IDHGNC:HGNC:11641
PHARMGKB IDPA36394
Map Location10q25.2-q25.3

GO terms in TCF7L2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0000122 negative regulation of transcription by RNA polymerase II
BP IMP GO:0001568 blood vessel development
BP IEA GO:0006351 transcription, DNA-templated
BP IBA GO:0006355 regulation of transcription, DNA-templated
BP IBA GO:0006357 regulation of transcription by RNA polymerase II
BP IDA GO:0006357 regulation of transcription by RNA polymerase II
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Gene expression in normal tissue: TCF7L2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 9BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Adenocarcinoma (COADREAD) model num: 4

Gene-drug pathway distribution

ERK MAPK signaling3Mitosis2RTK signaling1JNK and p38 signaling1Protein stability and degradation1IGFR signaling1Apoptosis regulation1

Pathways in TCF7L2


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Database
Pathway ID
Pathway Des.
wikipathways WP2118 Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathways WP363 Wnt Signaling Pathway
wikipathways WP3678 Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
wikipathways WP399 Wnt Signaling Pathway and Pluripotency
wikipathways WP4155 Endometrial cancer
wikipathways WP4216 Chromosomal and microsatellite instability in colorectal cancer
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD660 GSK-1070916 1
iGMDRD546 BMS-754807 1
iGMDRD117 Docetaxel 1
iGMDRD318 PAC-1 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TCF7L2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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