Summary: This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010].

transcription factor 7 like 2MIM:602228Ensembl:ENSG00000148737HGNC:HGNC:11641PA3639410q25.2-q25.3

GO terms in TCF7L2

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIMPGO:0001568blood vessel development
BPIEAGO:0006351transcription, DNA-templated
BPIBAGO:0006355regulation of transcription, DNA-templated
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIDAGO:0006357regulation of transcription by RNA polymerase II
BPIMPGO:0007050cell cycle arrest
BPTASGO:0007223Wnt signaling pathway, calcium modulating pathway
BPIMPGO:0008283cell proliferation
BPISSGO:0009749response to glucose
BPIMPGO:0010909positive regulation of heparan sulfate proteoglycan biosynthetic process
BPIBAGO:0016055Wnt signaling pathway
BPTASGO:0031016pancreas development
BPIMPGO:0032024positive regulation of insulin secretion
BPIDAGO:0032092positive regulation of protein binding
BPIDAGO:0032350regulation of hormone metabolic process
BPIDAGO:0042593glucose homeostasis
BPIDAGO:0043433negative regulation of DNA-binding transcription factor activity
BPIMPGO:0043570maintenance of DNA repeat elements
BPIMPGO:0044334canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
BPIDAGO:0045444fat cell differentiation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0046827positive regulation of protein export from nucleus
BPIDAGO:0048625myoblast fate commitment
BPIMPGO:0048660regulation of smooth muscle cell proliferation
BPIMPGO:0051897positive regulation of protein kinase B signaling
BPIBAGO:0060070canonical Wnt signaling pathway
BPICGO:0060070canonical Wnt signaling pathway
BPIMPGO:0090090negative regulation of canonical Wnt signaling pathway
BPTASGO:1904837beta-catenin-TCF complex assembly
BPISSGO:2000675negative regulation of type B pancreatic cell apoptotic process
BPISSGO:2001237negative regulation of extrinsic apoptotic signaling pathway
CCIDAGO:0000790nuclear chromatin
CCIBAGO:0005667transcription factor complex
CCIEAGO:0016605PML body
CCIDAGO:0032993protein-DNA complex
CCIDAGO:0070369beta-catenin-TCF7L2 complex
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIPIGO:0001103RNA polymerase II repressing transcription factor binding
MFIBAGO:0003682chromatin binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIBAGO:0008013beta-catenin binding
MFIDAGO:0008013beta-catenin binding
MFIPIGO:0008013beta-catenin binding
MFIPIGO:0008134transcription factor binding
MFIPIGO:0019901protein kinase binding
MFIPIGO:0035257nuclear hormone receptor binding
MFIBAGO:0043565sequence-specific DNA binding
MFIDAGO:0043565sequence-specific DNA binding
MFIMPGO:0043565sequence-specific DNA binding
MFIBAGO:0044212transcription regulatory region DNA binding
MFIDAGO:0044212transcription regulatory region DNA binding
MFIPIGO:0045295gamma-catenin binding
MFIPIGO:0070016armadillo repeat domain binding

Gene expression in normal tissue: TCF7L2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TCF7L2

DatabasePathway IDPathway Des.
wikipathwaysWP2118Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP3678Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
pidap1_pathwayAP-1 transcription factor network
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195253Degradation of beta-catenin by the destruction complex
reactomeR-HSA-195253Degradation of beta-catenin by the destruction complex
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201722Formation of the beta-catenin:TCF transactivating complex
reactomeR-HSA-201722Formation of the beta-catenin:TCF transactivating complex
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2980736Peptide hormone metabolism
reactomeR-HSA-3769402Deactivation of the beta-catenin transactivating complex
reactomeR-HSA-381771Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400508Incretin synthesis, secretion, and inactivation
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-4411364Binding of TCF/LEF:CTNNB1 to target gene promoters
reactomeR-HSA-4641265Repression of WNT target genes
reactomeR-HSA-4641265Repression of WNT target genes
reactomeR-HSA-4791275Signaling by WNT in cancer
reactomeR-HSA-5339700TCF7L2 mutants don't bind CTBP
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8951430RUNX3 regulates WNT signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD317CCT 0181591

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TCF7L2