MSH2


Summary: This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:609309
PHARMGKB IDPA31133
Map Location2p21-p16.3

GO terms in MSH2


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0000287 magnesium ion binding
MF IDA GO:0000287 magnesium ion binding
MF IBA GO:0000400 four-way junction DNA binding
MF IDA GO:0000400 four-way junction DNA binding
MF IBA GO:0000403 Y-form DNA binding
MF IBA GO:0000404 heteroduplex DNA loop binding
Showing 1 to 6 of 104 rows rows per page

Gene expression in normal tissue: MSH2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined44Other, kinases4Apoptosis regulation3PI3K/MTOR signaling2Stilbenoid, diarylheptanoid and gingerol biosynthesis1DNA replication1Protein stability and degradation1Genome integrity1Purine metabolism1Prostate cancer1

Pathways in MSH2


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-1643685 Disease
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-3700989 Transcriptional Regulation by TP53
reactome R-HSA-5358508 Mismatch Repair
reactome R-HSA-5358508 Mismatch Repair
reactome R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Showing 1 to 6 of 27 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD60 Quinoclamine 1
iGMDRD371 THR1 Inhibitor 1
iGMDRD577 BIX01294 1
iGMDRD562 Navitoclax 2
Showing 1 to 4 of 66 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MSH2

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​