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MEDI0680
iGMDRD941
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Standard Name
Drug Status
Standard Name
MEDI0680
Drug Status
Alone
Drug-model tissue-cancer distribution: Bubble Plot
BLADDE
tissue: BLADDE cancer: BLADDER model num: 0
BLADDER
tissue: BLADDER cancer: Urethral Urothelial Carcinoma (UCU) model num: 2
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Drug-gene pathway enrichments
3
reactome: DNA Repair
3
reactome: Mismatch Repair
2
kegg: Mismatch repair - Homo sapiens (human)
2
wikipathways: Mismatch repair
2
kegg: Colorectal cancer - Homo sapiens (human)
2
reactome: Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
2
wikipathways: Chromosomal and microsatellite instability in colorectal cancer
2
reactome: Disease
2
kegg: Pathways in cancer - Homo sapiens (human)
2
reactome: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
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Drug-gene GO enrichments
9
BP: mismatch repair
5
MF: guanine/thymine mispair binding
5
MF: mismatched DNA binding
4
MF: single thymine insertion binding
4
BP: maintenance of DNA repeat elements
4
MF: MutLalpha complex binding
4
MF: ADP binding
4
CC: MutSalpha complex
4
BP: determination of adult lifespan
4
MF: four-way junction DNA binding
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Drug-Gene: Aster Plot
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Gene ID
Gene Name
Model Num.
2956
MSH6
1
4436
MSH2
1
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4
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1
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Gene in drug-gene network: Network Plot
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Models in MEDI0680
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found
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