B2M

Summary: This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namebeta-2-microglobulin
OMIM IDMIM:109700
Ensembl IDEnsembl:ENSG00000166710
HGNC IDHGNC:HGNC:914
PHARMGKB IDPA25207
Map Location15q21.1

GO terms in B2M


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IPI GO:0042802 identical protein binding
BP HEP GO:0001895 retina homeostasis
BP IEA GO:0001916 positive regulation of T cell mediated cytotoxicity
BP IEA GO:0002237 response to molecule of bacterial origin
BP TAS GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
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Gene expression in normal tissue: B2M

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Adenocarcinoma (COADREAD) model num: 2LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 5SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 1SKINtissue: SKIN cancer: Melanoma (MEL) model num: 2

Gene-drug pathway distribution

undefined4ERK MAPK signaling2Cell cycle1JNK and p38 signaling1Chromatin other1Chromatin histone acetylation1

Pathways in B2M


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1236974 ER-Phagosome pathway
reactome R-HSA-1236974 ER-Phagosome pathway
reactome R-HSA-1236975 Antigen processing-Cross presentation
reactome R-HSA-1236975 Antigen processing-Cross presentation
reactome R-HSA-1236977 Endosomal/Vacuolar pathway
reactome R-HSA-1280215 Cytokine Signaling in Immune system
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD608 Refametinib 1
iGMDRD658 CHEMBL1673039 1
iGMDRD662 JQ-1 1
iGMDRD470 Trametinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in B2M

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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