Summary: This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014].


GO terms in B2M

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
BPHEPGO:0001895retina homeostasis
BPIEAGO:0001916positive regulation of T cell mediated cytotoxicity
BPIEAGO:0002237response to molecule of bacterial origin
BPTASGO:0002474antigen processing and presentation of peptide antigen via MHC class I
BPTASGO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
BPTASGO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
BPIEAGO:0002481antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
BPIDAGO:0002726positive regulation of T cell cytokine production
BPIEAGO:0010977negative regulation of neuron projection development
BPIGIGO:0019885antigen processing and presentation of endogenous peptide antigen via MHC class I
BPIGIGO:0032092positive regulation of protein binding
BPIEAGO:0033077T cell differentiation in thymus
BPIEAGO:0033216ferric iron import
BPIEAGO:0042026protein refolding
BPIEAGO:0042493response to drug
BPTASGO:0043312neutrophil degranulation
BPTASGO:0044267cellular protein metabolic process
BPTASGO:0045087innate immune response
BPIEAGO:0045646regulation of erythrocyte differentiation
BPIEAGO:0046686response to cadmium ion
BPIGIGO:0048260positive regulation of receptor-mediated endocytosis
BPTASGO:0050690regulation of defense response to virus by virus
BPTASGO:0050776regulation of immune response
BPICGO:0055072iron ion homeostasis
BPTASGO:0060333interferon-gamma-mediated signaling pathway
BPIGIGO:0071281cellular response to iron ion
BPIEAGO:0071283cellular response to iron(III) ion
BPIDAGO:1900121negative regulation of receptor binding
BPIGIGO:1900122positive regulation of receptor binding
BPIGIGO:1900390regulation of iron ion import
BPIGIGO:1904434positive regulation of ferrous iron binding
BPIGIGO:1904437positive regulation of transferrin receptor binding
CCTASGO:0000139Golgi membrane
CCTASGO:0005576extracellular region
CCHDAGO:0005615extracellular space
CCTASGO:0005788endoplasmic reticulum lumen
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCHDAGO:0005925focal adhesion
CCIEAGO:0009897external side of plasma membrane
CCTASGO:0012507ER to Golgi transport vesicle membrane
CCTASGO:0030670phagocytic vesicle membrane
CCTASGO:0031901early endosome membrane
CCTASGO:0031905early endosome lumen
CCTASGO:0035580specific granule lumen
CCIEAGO:0042612MHC class I protein complex
CCTASGO:0055038recycling endosome membrane
CCHDAGO:0070062extracellular exosome
CCTASGO:1904724tertiary granule lumen
CCIDAGO:1990712HFE-transferrin receptor complex

Gene expression in normal tissue: B2M

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in B2M

DatabasePathway IDPathway Des.
reactomeR-HSA-1236974ER-Phagosome pathway
reactomeR-HSA-1236974ER-Phagosome pathway
reactomeR-HSA-1236975Antigen processing-Cross presentation
reactomeR-HSA-1236975Antigen processing-Cross presentation
reactomeR-HSA-1236977Endosomal/Vacuolar pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162909Host Interactions of HIV factors
reactomeR-HSA-164938Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
reactomeR-HSA-164940Nef mediated downregulation of MHC class I complex cell surface expression
reactomeR-HSA-164952The role of Nef in HIV-1 replication and disease pathogenesis
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
reactomeR-HSA-2172127DAP12 interactions
reactomeR-HSA-2172127DAP12 interactions
reactomeR-HSA-2424491DAP12 signaling
reactomeR-HSA-2424491DAP12 signaling
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-977225Amyloid fiber formation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983170Antigen Presentation: Folding, assembly and peptide loading of class I MHC
biocartamhcpathwayantigen processing and presentation
biocartankcellspathwayras-independent pathway in nk cell-mediated cytotoxicity
kegghsa04612Antigen processing and presentation - Homo sapiens (human)
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidil12_2pathwayIL12-mediated signaling events

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD973PD1 Ab inhibitor1
iGMDRD974PD1 blockade1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in B2M