B2M
Summary: This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| beta-2-microglobulin | MIM:109700 | Ensembl:ENSG00000166710 | HGNC:HGNC:914 | PA25207 | 15q21.1 |
GO terms in B2M
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| BP | HEP | GO:0001895 | retina homeostasis |
| BP | IEA | GO:0001916 | positive regulation of T cell mediated cytotoxicity |
| BP | IEA | GO:0002237 | response to molecule of bacterial origin |
| BP | TAS | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I |
| BP | TAS | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| BP | TAS | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent |
| BP | IEA | GO:0002481 | antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent |
| BP | IDA | GO:0002726 | positive regulation of T cell cytokine production |
| BP | IEA | GO:0010977 | negative regulation of neuron projection development |
| BP | IGI | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| BP | IGI | GO:0032092 | positive regulation of protein binding |
| BP | IEA | GO:0033077 | T cell differentiation in thymus |
| BP | IEA | GO:0033216 | ferric iron import |
| BP | IEA | GO:0042026 | protein refolding |
| BP | IEA | GO:0042493 | response to drug |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | TAS | GO:0045087 | innate immune response |
| BP | IEA | GO:0045646 | regulation of erythrocyte differentiation |
| BP | IEA | GO:0046686 | response to cadmium ion |
| BP | IGI | GO:0048260 | positive regulation of receptor-mediated endocytosis |
| BP | TAS | GO:0050690 | regulation of defense response to virus by virus |
| BP | TAS | GO:0050776 | regulation of immune response |
| BP | IC | GO:0055072 | iron ion homeostasis |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | IGI | GO:0071281 | cellular response to iron ion |
| BP | IEA | GO:0071283 | cellular response to iron(III) ion |
| BP | IDA | GO:1900121 | negative regulation of receptor binding |
| BP | IGI | GO:1900122 | positive regulation of receptor binding |
| BP | IGI | GO:1900390 | regulation of iron ion import |
| BP | IGI | GO:1904434 | positive regulation of ferrous iron binding |
| BP | IGI | GO:1904437 | positive regulation of transferrin receptor binding |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | TAS | GO:0012507 | ER to Golgi transport vesicle membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | TAS | GO:0030670 | phagocytic vesicle membrane |
| CC | TAS | GO:0031901 | early endosome membrane |
| CC | TAS | GO:0031905 | early endosome lumen |
| CC | TAS | GO:0035580 | specific granule lumen |
| CC | IEA | GO:0042612 | MHC class I protein complex |
| CC | TAS | GO:0055038 | recycling endosome membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:1904724 | tertiary granule lumen |
| CC | IDA | GO:1990712 | HFE-transferrin receptor complex |
Gene expression in normal tissue: B2M
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in B2M
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1236974 | ER-Phagosome pathway |
| reactome | R-HSA-1236974 | ER-Phagosome pathway |
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1236977 | Endosomal/Vacuolar pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| reactome | R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression |
| reactome | R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-977225 | Amyloid fiber formation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| reactome | R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| biocarta | mhcpathway | antigen processing and presentation |
| biocarta | nkcellspathway | ras-independent pathway in nk cell-mediated cytotoxicity |
| kegg | hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | il12_2pathway | IL12-mediated signaling events |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD608 | Refametinib | 1 |
| iGMDRD658 | CHEMBL1673039 | 1 |
| iGMDRD662 | JQ-1 | 1 |
| iGMDRD470 | Trametinib | 1 |
| iGMDRD978 | Pembrolizumab | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD386 | TAK-715 | 1 |
| iGMDRD550 | CGP-082996 | 1 |
| iGMDRD973 | PD1 Ab inhibitor | 1 |
| iGMDRD974 | PD1 blockade | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in B2M
CLASSFICATION
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