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BCL2

Summary: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
BCL2, apoptosis regulator	MIM:151430	Ensembl:ENSG00000171791	HGNC:HGNC:990	PA25302	18q21.33

Gene Categories:

CLINICALLY ACTIONABLE TUMOR SUPPRESSOR TRANSCRIPTION FACTOR BINDING DRUG RESISTANCE TRANSPORTER DRUGGABLE GENOME

GO terms in BCL2

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005739	mitochondrion
CC	IBA	GO:0005741	mitochondrial outer membrane
CC	IDA	GO:0005741	mitochondrial outer membrane
CC	TAS	GO:0005741	mitochondrial outer membrane
CC	IDA	GO:0005783	endoplasmic reticulum
CC	IEA	GO:0005789	endoplasmic reticulum membrane
CC	IEA	GO:0005829	cytosol
CC	IDA	GO:0016020	membrane
CC	IDA	GO:0031965	nuclear membrane
CC	IMP	GO:0032991	protein-containing complex
CC	IEA	GO:0043209	myelin sheath
CC	IDA	GO:0046930	pore complex
BP	IDA	GO:0000209	protein polyubiquitination
BP	IEA	GO:0001503	ossification
BP	IEA	GO:0001541	ovarian follicle development
BP	IEA	GO:0001656	metanephros development
BP	IEA	GO:0001658	branching involved in ureteric bud morphogenesis
BP	IEA	GO:0001662	behavioral fear response
BP	IEA	GO:0001782	B cell homeostasis
BP	ISS	GO:0001836	release of cytochrome c from mitochondria
BP	NAS	GO:0001836	release of cytochrome c from mitochondria
BP	IEA	GO:0001952	regulation of cell-matrix adhesion
BP	IEA	GO:0002320	lymphoid progenitor cell differentiation
BP	IEA	GO:0002326	B cell lineage commitment
BP	IEA	GO:0002931	response to ischemia
BP	IEA	GO:0003014	renal system process
BP	IEA	GO:0006470	protein dephosphorylation
BP	IEA	GO:0006582	melanin metabolic process
BP	IEA	GO:0006808	regulation of nitrogen utilization
BP	IDA	GO:0006915	apoptotic process
BP	TAS	GO:0006959	humoral immune response
BP	IMP	GO:0006974	cellular response to DNA damage stimulus
BP	IEA	GO:0007015	actin filament organization
BP	IEA	GO:0007409	axonogenesis
BP	NAS	GO:0007565	female pregnancy
BP	IEA	GO:0007569	cell aging
BP	IEA	GO:0008584	male gonad development
BP	IDA	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
BP	IBA	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
BP	IEA	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
BP	NAS	GO:0009314	response to radiation
BP	IDA	GO:0009636	response to toxic substance
BP	IEA	GO:0009791	post-embryonic development
BP	IDA	GO:0010039	response to iron ion
BP	IEA	GO:0010224	response to UV-B
BP	IEA	GO:0010332	response to gamma radiation
BP	IEA	GO:0010468	regulation of gene expression
BP	TAS	GO:0010507	negative regulation of autophagy
BP	IEA	GO:0010523	negative regulation of calcium ion transport into cytosol
BP	IEA	GO:0010559	regulation of glycoprotein biosynthetic process
BP	IEA	GO:0014031	mesenchymal cell development
BP	IEA	GO:0014042	positive regulation of neuron maturation
BP	IEA	GO:0014911	positive regulation of smooth muscle cell migration
BP	IEA	GO:0018105	peptidyl-serine phosphorylation
BP	IEA	GO:0018107	peptidyl-threonine phosphorylation
BP	TAS	GO:0019221	cytokine-mediated signaling pathway
BP	IEA	GO:0021747	cochlear nucleus development
BP	IEA	GO:0022612	gland morphogenesis
BP	IDA	GO:0022898	regulation of transmembrane transporter activity
BP	IEA	GO:0030279	negative regulation of ossification
BP	IDA	GO:0030307	positive regulation of cell growth
BP	IEA	GO:0030308	negative regulation of cell growth
BP	IEA	GO:0030318	melanocyte differentiation
BP	IEA	GO:0030336	negative regulation of cell migration
BP	IMP	GO:0030890	positive regulation of B cell proliferation
BP	IEA	GO:0031069	hair follicle morphogenesis
BP	IEA	GO:0031103	axon regeneration
BP	IEA	GO:0031647	regulation of protein stability
BP	TAS	GO:0032469	endoplasmic reticulum calcium ion homeostasis
BP	IEA	GO:0032835	glomerulus development
BP	IDA	GO:0032848	negative regulation of cellular pH reduction
BP	IEA	GO:0033033	negative regulation of myeloid cell apoptotic process
BP	IEA	GO:0033077	T cell differentiation in thymus
BP	IEA	GO:0033138	positive regulation of peptidyl-serine phosphorylation
BP	IEA	GO:0033689	negative regulation of osteoblast proliferation
BP	IDA	GO:0034097	response to cytokine
BP	IDA	GO:0035094	response to nicotine
BP	IEA	GO:0035265	organ growth
BP	IEA	GO:0040018	positive regulation of multicellular organism growth
BP	IDA	GO:0042100	B cell proliferation
BP	IEA	GO:0042149	cellular response to glucose starvation
BP	IDA	GO:0042493	response to drug
BP	IMP	GO:0042493	response to drug
BP	IEA	GO:0042542	response to hydrogen peroxide
BP	IEA	GO:0043029	T cell homeostasis
BP	IBA	GO:0043066	negative regulation of apoptotic process
BP	IDA	GO:0043066	negative regulation of apoptotic process
BP	IGI	GO:0043066	negative regulation of apoptotic process
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	TAS	GO:0043066	negative regulation of apoptotic process
BP	IEA	GO:0043085	positive regulation of catalytic activity
BP	IEA	GO:0043375	CD8-positive, alpha-beta T cell lineage commitment
BP	IDA	GO:0043496	regulation of protein homodimerization activity
BP	IDA	GO:0043497	regulation of protein heterodimerization activity
BP	IDA	GO:0043524	negative regulation of neuron apoptotic process
BP	IEA	GO:0043583	ear development
BP	IEA	GO:0045069	regulation of viral genome replication
BP	IEA	GO:0045636	positive regulation of melanocyte differentiation
BP	IEA	GO:0046671	negative regulation of retinal cell programmed cell death
BP	ISS	GO:0046902	regulation of mitochondrial membrane permeability
BP	IEA	GO:0048041	focal adhesion assembly
BP	IEA	GO:0048536	spleen development
BP	IEA	GO:0048538	thymus development
BP	IEA	GO:0048546	digestive tract morphogenesis
BP	IEA	GO:0048599	oocyte development
BP	IEA	GO:0048743	positive regulation of skeletal muscle fiber development
BP	IEA	GO:0048753	pigment granule organization
BP	IEA	GO:0048873	homeostasis of number of cells within a tissue
BP	IMP	GO:0050853	B cell receptor signaling pathway
BP	IEA	GO:0051384	response to glucocorticoid
BP	TAS	GO:0051402	neuron apoptotic process
BP	IDA	GO:0051607	defense response to virus
BP	ISS	GO:0051881	regulation of mitochondrial membrane potential
BP	TAS	GO:0051902	negative regulation of mitochondrial depolarization
BP	IDA	GO:0051924	regulation of calcium ion transport
BP	IEA	GO:0055085	transmembrane transport
BP	IDA	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
BP	IEA	GO:0071456	cellular response to hypoxia
BP	IEA	GO:0072593	reactive oxygen species metabolic process
BP	IBA	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
BP	IEA	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
BP	IEA	GO:0098609	cell-cell adhesion
BP	TAS	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BP	IEA	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle
BP	IEA	GO:2000378	negative regulation of reactive oxygen species metabolic process
BP	IMP	GO:2000811	negative regulation of anoikis
BP	IMP	GO:2001234	negative regulation of apoptotic signaling pathway
BP	IGI	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
BP	IBA	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
BP	IDA	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
BP	TAS	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
MF	IDA	GO:0002020	protease binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0008134	transcription factor binding
MF	IDA	GO:0015267	channel activity
MF	IDA	GO:0016248	channel inhibitor activity
MF	IPI	GO:0031625	ubiquitin protein ligase binding
MF	IPI	GO:0042802	identical protein binding
MF	IBA	GO:0042803	protein homodimerization activity
MF	IPI	GO:0042803	protein homodimerization activity
MF	IDA	GO:0043565	sequence-specific DNA binding
MF	IBA	GO:0046982	protein heterodimerization activity
MF	IPI	GO:0046982	protein heterodimerization activity
MF	IPI	GO:0051434	BH3 domain binding
MF	IEA	GO:0051721	protein phosphatase 2A binding

Gene expression in normal tissue: BCL2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCL2

Database	Pathway ID	Pathway Des.
biocarta	badpathway	regulation of bad phosphorylation
biocarta	carm1pathway	transcription regulation by methyltransferase of carm1
biocarta	ceramidepathway	ceramide signaling pathway
biocarta	chemicalpathway	apoptotic signaling in response to dna damage
biocarta	gleevecpathway	inhibition of cellular proliferation by gleevec
biocarta	hivnefpathway	hiv-1 nef: negative effector of fas and tnf
biocarta	hsp27pathway	stress induction of hsp regulation
biocarta	il2rbpathway	il-2 receptor beta chain in t cell activation
biocarta	il7pathway	il-7 signal transduction
biocarta	keratinocytepathway	keratinocyte differentiation
biocarta	melanocytepathway	melanocyte development and pigmentation pathway
biocarta	mitochondriapathway	role of mitochondria in apoptotic signaling
biocarta	p53pathway	p53 signaling pathway
biocarta	prionpathway	prion pathway
biocarta	telpathway	telomeres telomerase cellular aging and immortality
reactome	R-HSA-109581	Apoptosis
reactome	R-HSA-109606	Intrinsic Pathway for Apoptosis
reactome	R-HSA-111447	Activation of BAD and translocation to mitochondria
reactome	R-HSA-111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
reactome	R-HSA-114452	Activation of BH3-only proteins
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-5357801	Programmed Cell Death
reactome	R-HSA-622312	Inflammasomes
reactome	R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling
reactome	R-HSA-844455	The NLRP1 inflammasome
reactome	R-HSA-8939211	ESR-mediated signaling
reactome	R-HSA-9006931	Signaling by Nuclear Receptors
reactome	R-HSA-9018519	Estrogen-dependent gene expression
wikipathways	WP127	IL-5 Signaling Pathway
wikipathways	WP1438	Influenza A virus infection
wikipathways	WP1742	TP53 Network
wikipathways	WP1772	Apoptosis Modulation and Signaling
wikipathways	WP2003	miR-targeted genes in leukocytes - TarBase
wikipathways	WP2004	miR-targeted genes in lymphocytes - TarBase
wikipathways	WP2005	miR-targeted genes in muscle cell - TarBase
wikipathways	WP2332	Interleukin-11 Signaling Pathway
wikipathways	WP2355	Corticotropin-releasing hormone signaling pathway
wikipathways	WP2447	Amyotrophic lateral sclerosis (ALS)
wikipathways	WP2509	Nanoparticle triggered autophagic cell death
wikipathways	WP254	Apoptosis
wikipathways	WP286	IL-3 Signaling Pathway
wikipathways	WP304	Kit receptor signaling pathway
wikipathways	WP306	Focal Adhesion
wikipathways	WP314	Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathways	WP3287	Overview of nanoparticle effects
wikipathways	WP3611	Photodynamic therapy-induced AP-1 survival signaling.
wikipathways	WP3639	Apoptotic Signaling Pathway
wikipathways	WP3657	Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex
wikipathways	WP3872	Regulation of Apoptosis by Parathyroid Hormone-related Protein
wikipathways	WP3888	VEGFA-VEGFR2 Signaling Pathway
wikipathways	WP3941	Oxidative Damage
wikipathways	WP3981	miRNA regulation of prostate cancer signaling pathways
wikipathways	WP3995	Prion disease pathway
wikipathways	WP4008	NO-cGMP-PKG mediated Neuroprotection
wikipathways	WP4066	Interleukin-4 and 13 signaling
wikipathways	WP4172	PI3K-Akt Signaling Pathway
wikipathways	WP4216	Chromosomal and microsatellite instability in colorectal cancer
wikipathways	WP4249	Hedgehog Signaling Pathway
wikipathways	WP49	IL-2 Signaling Pathway
wikipathways	WP615	Senescence and Autophagy in Cancer
wikipathways	WP710	DNA Damage Response (only ATM dependent)
wikipathways	WP712	Estrogen signaling pathway
pid	atf2_pathway	ATF-2 transcription factor network
pid	caspase_pathway	Caspase Cascade in Apoptosis
pid	ceramide_pathway	Ceramide signaling pathway
pid	cmyb_pathway	C-MYB transcription factor network
pid	epopathway	EPO signaling pathway
pid	hivnefpathway	HIV-1 Nef: Negative effector of Fas and TNF-alpha
pid	il2_1pathway	IL2-mediated signaling events
pid	il2_pi3kpathway	IL2 signaling events mediated by PI3K
pid	il2_stat5pathway	IL2 signaling events mediated by STAT5
pid	kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)
pid	myc_represspathway	Validated targets of C-MYC transcriptional repression
pid	nfat_3pathway	Role of Calcineurin-dependent NFAT signaling in lymphocytes
pid	p53downstreampathway	Direct p53 effectors
pid	rxr_vdr_pathway	RXR and RAR heterodimerization with other nuclear receptor
netpath	Pathway_EGFR1	EGFR1
netpath	Pathway_IL2	IL2
netpath	Pathway_IL3	IL3
pharmgkb	PA150981002	Vinka Alkaloid Pathway, Pharmacokinetics
pharmgkb	PA165374494	Busulfan Pathway, Pharmacodynamics
kegg	hsa04064	NF-kappa B signaling pathway - Homo sapiens (human)
kegg	hsa04066	HIF-1 signaling pathway - Homo sapiens (human)
kegg	hsa04071	Sphingolipid signaling pathway - Homo sapiens (human)
kegg	hsa04140	Autophagy - animal - Homo sapiens (human)
kegg	hsa04141	Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa04210	Apoptosis - Homo sapiens (human)
kegg	hsa04215	Apoptosis - multiple species - Homo sapiens (human)
kegg	hsa04217	Necroptosis - Homo sapiens (human)
kegg	hsa04261	Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegg	hsa04340	Hedgehog signaling pathway - Homo sapiens (human)
kegg	hsa04510	Focal adhesion - Homo sapiens (human)
kegg	hsa04621	NOD-like receptor signaling pathway - Homo sapiens (human)
kegg	hsa04630	Jak-STAT signaling pathway - Homo sapiens (human)
kegg	hsa04722	Neurotrophin signaling pathway - Homo sapiens (human)
kegg	hsa04725	Cholinergic synapse - Homo sapiens (human)
kegg	hsa04915	Estrogen signaling pathway - Homo sapiens (human)
kegg	hsa04933	AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegg	hsa05014	Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegg	hsa05145	Toxoplasmosis - Homo sapiens (human)
kegg	hsa05152	Tuberculosis - Homo sapiens (human)
kegg	hsa05161	Hepatitis B - Homo sapiens (human)
kegg	hsa05169	Epstein-Barr virus infection - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05206	MicroRNAs in cancer - Homo sapiens (human)
kegg	hsa05210	Colorectal cancer - Homo sapiens (human)
kegg	hsa05215	Prostate cancer - Homo sapiens (human)
kegg	hsa05222	Small cell lung cancer - Homo sapiens (human)
kegg	hsa05226	Gastric cancer - Homo sapiens (human)
kegg	hsa05418	Fluid shear stress and atherosclerosis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD352	PD-0325901	1
iGMDRD329	Merck60	3
iGMDRD163	all trans Retinoic Acid	1
iGMDRD748	PHA-665752	1
iGMDRD608	Refametinib	1
iGMDRD498	GW441756X	1
iGMDRD690	PRIMA-1MET	1
iGMDRD832	BCL2 inhibitor	2
iGMDRD568	SCHEMBL15005512	1
iGMDRD387	CHIR-99021	3
iGMDRD79	Gemcitabine	3
iGMDRD781	Sirolimus	3
iGMDRD427	ABT737	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL2

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.