BCL2
Summary: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:151430 Ensembl IDEnsembl:ENSG00000171791 HGNC IDHGNC:HGNC:990 PHARMGKB IDPA25302 Map Location18q21.33 |
GO terms in BCL2
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005739 | mitochondrion |
CC | IBA | GO:0005741 | mitochondrial outer membrane |
CC | IDA | GO:0005741 | mitochondrial outer membrane |
Gene expression in normal tissue: BCL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCL2
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Database | Pathway ID | Pathway Des. |
---|---|---|
biocarta | badpathway | regulation of bad phosphorylation |
biocarta | carm1pathway | transcription regulation by methyltransferase of carm1 |
biocarta | ceramidepathway | ceramide signaling pathway |
biocarta | chemicalpathway | apoptotic signaling in response to dna damage |
biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in BCL2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |