BCL2

Summary: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameBCL2, apoptosis regulator
OMIM IDMIM:151430
Ensembl IDEnsembl:ENSG00000171791
HGNC IDHGNC:HGNC:990
PHARMGKB IDPA25302
Map Location18q21.33

GO terms in BCL2


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005634 nucleus
CC IDA GO:0005654 nucleoplasm
CC IDA GO:0005737 cytoplasm
CC IDA GO:0005739 mitochondrion
CC IBA GO:0005741 mitochondrial outer membrane
CC IDA GO:0005741 mitochondrial outer membrane
Showing 1 to 6 of 148 rows rows per page

Gene expression in normal tissue: BCL2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 20undefinedtissue: undefined cancer: Lymphoma model num: 2BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 2

Gene-drug pathway distribution

Pathways in BCL2


Loading, please wait...
Database
Pathway ID
Pathway Des.
biocarta badpathway regulation of bad phosphorylation
biocarta carm1pathway transcription regulation by methyltransferase of carm1
biocarta ceramidepathway ceramide signaling pathway
biocarta chemicalpathway apoptotic signaling in response to dna damage
biocarta gleevecpathway inhibition of cellular proliferation by gleevec
biocarta hivnefpathway hiv-1 nef: negative effector of fas and tnf
Showing 1 to 6 of 116 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD352 PD-0325901 1
iGMDRD329 Merck60 3
iGMDRD163 all trans Retinoic Acid 1
iGMDRD748 PHA-665752 1
Showing 1 to 4 of 13 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL2

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.