IGFBP2


Summary: The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in IGFBP2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0005102 signaling receptor binding
MF IPI GO:0005515 protein binding
MF IBA GO:0031994 insulin-like growth factor I binding
MF IDA GO:0031994 insulin-like growth factor I binding
MF IBA GO:0031995 insulin-like growth factor II binding
MF ISS GO:0031995 insulin-like growth factor II binding
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Gene expression in normal tissue: IGFBP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IGFBP2


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Database
Pathway ID
Pathway Des.
wikipathways WP289 Myometrial Relaxation and Contraction Pathways
wikipathways WP3391 Senescence-Associated Secretory Phenotype (SASP)
wikipathways WP3614 Photodynamic therapy-induced HIF-1 survival signaling
reactome R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactome R-HSA-392499 Metabolism of proteins
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD358 Semagacestat 1
iGMDRD142 NSC74859 1
iGMDRD297 Austocystin D 1
iGMDRD394 BX-795 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IGFBP2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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