EPHA2
Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| EPH receptor A2 | MIM:176946 | Ensembl:ENSG00000142627 | HGNC:HGNC:3386 | PA27818 | 1p36.13 |
GO terms in EPHA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005622 | intracellular |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | HDA | GO:0009986 | cell surface |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | IDA | GO:0031256 | leading edge membrane |
| CC | IEA | GO:0031258 | lamellipodium membrane |
| CC | IEA | GO:0032587 | ruffle membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043235 | receptor complex |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | ISS | GO:0001649 | osteoblast differentiation |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IDA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IMP | GO:0010591 | regulation of lamellipodium assembly |
| BP | IMP | GO:0016477 | cell migration |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IMP | GO:0030216 | keratinocyte differentiation |
| BP | ISS | GO:0030316 | osteoclast differentiation |
| BP | ISS | GO:0033598 | mammary gland epithelial cell proliferation |
| BP | IDA | GO:0033628 | regulation of cell adhesion mediated by integrin |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IDA | GO:0043491 | protein kinase B signaling |
| BP | ISS | GO:0043535 | regulation of blood vessel endothelial cell migration |
| BP | ISS | GO:0045765 | regulation of angiogenesis |
| BP | IMP | GO:0046058 | cAMP metabolic process |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | ISS | GO:0046849 | bone remodeling |
| BP | IDA | GO:0048013 | ephrin receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IMP | GO:0048870 | cell motility |
| BP | IDA | GO:0051898 | negative regulation of protein kinase B signaling |
| BP | IMP | GO:0060326 | cell chemotaxis |
| BP | ISS | GO:0060444 | branching involved in mammary gland duct morphogenesis |
| BP | ISS | GO:0070309 | lens fiber cell morphogenesis |
| BP | IMP | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070848 | response to growth factor |
| BP | IMP | GO:0090630 | activation of GTPase activity |
| BP | IMP | GO:1903078 | positive regulation of protein localization to plasma membrane |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IDA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IEA | GO:0005003 | ephrin receptor activity |
| MF | IBA | GO:0005005 | transmembrane-ephrin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | HDA | GO:0045296 | cadherin binding |
Gene expression in normal tissue: EPHA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | arf6_pathway | Arf6 signaling events |
| pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
| pid | epha2_fwdpathway | EPHA2 forward signaling |
| pid | epha_fwdpathway | EPHA forward signaling |
| pid | p53downstreampathway | Direct p53 effectors |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD239 | Dasatinib | 4 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD885 | Compound 110 | 4 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD782 | DC-45-A2 | 4 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD640 | CAY10618 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD137 | Indisulam | 10 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD949 | mTOR inhibitor | 2 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPHA2
CLASSFICATION
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