INPP4B
Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:607494 Ensembl IDEnsembl:ENSG00000109452 HGNC IDHGNC:HGNC:6075 PHARMGKB IDPA29883 Map Location4q31.21 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in INPP4B
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IBA | GO:0005737 | cytoplasm |
CC | TAS | GO:0005829 | cytosol |
BP | TAS | GO:0006661 | phosphatidylinositol biosynthetic process |
BP | TAS | GO:0007165 | signal transduction |
BP | IEA | GO:0016311 | dephosphorylation |
BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
Gene expression in normal tissue: INPP4B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in INPP4B
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Database | Pathway ID | Pathway Des. |
---|---|---|
humancyc | PWY-6368 | 3-phosphoinositide degradation |
kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
smpdb | SMP00462 | Inositol Phosphate Metabolism |
smpdb | SMP00463 | Phosphatidylinositol Phosphate Metabolism |
smpdb | SMP00582 | Joubert syndrome |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in INPP4B
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |