INPP4B


Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008].

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Gene Categories:

CLINICALLY ACTIONABLE

GO terms in INPP4B


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005737 cytoplasm
CC TAS GO:0005829 cytosol
BP TAS GO:0006661 phosphatidylinositol biosynthetic process
BP TAS GO:0007165 signal transduction
BP IEA GO:0016311 dephosphorylation
BP IEA GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
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Gene expression in normal tissue: INPP4B

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 10undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 84LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 1BREASTtissue: BREAST cancer: Invasive Breast Carcinoma (BRCA) model num: 2BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1

Gene-drug pathway distribution

undefined28Cell cycle2Other, kinases2Genome integrity2EGFR signaling2Mitosis1PI3K/MTOR signaling1Protein stability and degradation1RTK signaling1Chromatin histone acetylation1

Pathways in INPP4B


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Database
Pathway ID
Pathway Des.
humancyc PWY-6368 3-phosphoinositide degradation
kegg hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
kegg hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
smpdb SMP00462 Inositol Phosphate Metabolism
smpdb SMP00463 Phosphatidylinositol Phosphate Metabolism
smpdb SMP00582 Joubert syndrome
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD441 TW 37 1
iGMDRD983 PI3K pathway inhibitor 3
iGMDRD171 Pemetrexed 2
iGMDRD802 4-methylfasudil 5
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in INPP4B

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Model
Level
Reference ID
Tissue
Cancer
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No matching records found

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