INPP4B


Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
inositol polyphosphate-4-phosphatase type II BMIM:607494Ensembl:ENSG00000109452HGNC:HGNC:6075PA298834q31.21

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in INPP4B


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
BPTASGO:0006661phosphatidylinositol biosynthetic process
BPTASGO:0007165signal transduction
BPIEAGO:0016311dephosphorylation
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPTASGO:0043647inositol phosphate metabolic process
MFIPIGO:0005515protein binding
MFIBAGO:0016316phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
MFTASGO:0016316phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
MFTASGO:0017161inositol-1,3,4-trisphosphate 4-phosphatase activity
MFIEAGO:0034597phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
MFTASGO:0052828inositol-3,4-bisphosphate 4-phosphatase activity

Gene expression in normal tissue: INPP4B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in INPP4B


DatabasePathway IDPathway Des.
humancycPWY-63683-phosphoinositide degradation
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
smpdbSMP00462Inositol Phosphate Metabolism
smpdbSMP00463Phosphatidylinositol Phosphate Metabolism
smpdbSMP00582Joubert syndrome
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483249Inositol phosphate metabolism
reactomeR-HSA-1483255PI Metabolism
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-1660499Synthesis of PIPs at the plasma membrane
reactomeR-HSA-1660516Synthesis of PIPs at the early endosome membrane
reactomeR-HSA-1855183Synthesis of IP2, IP, and Ins in the cytosol
reactomeR-HSA-556833Metabolism of lipids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD441TW 371
iGMDRD983PI3K pathway inhibitor3
iGMDRD171Pemetrexed2
iGMDRD8024-methylfasudil5
iGMDRD356PNU-746543
iGMDRD524ISX-92
iGMDRD131Erlotinib2
iGMDRD431NU-74411
iGMDRD64Parbendazole2
iGMDRD506Fedratinib2
iGMDRD100Zebularine3
iGMDRD188Piperlongumine2
iGMDRD74Idarubicin2
iGMDRD399Selumetinib1
iGMDRD483SCH-5290742
iGMDRD489GSK-4613641
iGMDRD63Camptothecin2
iGMDRD427ABT7373
iGMDRD239Dasatinib1
iGMDRD546BMS-7548072
iGMDRD387CHIR-990212
iGMDRD126Tipifarnib4
iGMDRD313Axitinib2
iGMDRD394BX-7952
iGMDRD280CYTOCHALASIN B5
iGMDRD401Afatinib1
iGMDRD193Fqi12
iGMDRD446LY 21832403
iGMDRD253Vincaleukoblastine1
iGMDRD105Triptolide2
iGMDRD402AKT Inhibitor VIII1
iGMDRD137Indisulam4
iGMDRD42Vorinostat1
iGMDRD421AZD77621
iGMDRD886Compound 1541A2
iGMDRD329Merck603
iGMDRD658CHEMBL16730391
iGMDRD871BRD63683
iGMDRD405PIK-753
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD262KU-559331
iGMDRD382CEP-7011
iGMDRD39Pyrimethamine1
iGMDRD945ML2143
iGMDRD901ELCPK3
iGMDRD123Isoevodiamine3
iGMDRD314Tanespimycin3
iGMDRD351GW843682X2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in INPP4B

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