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CSF3R

Summary: The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namecolony stimulating factor 3 receptor OMIM IDMIM:138971 Ensembl IDEnsembl:ENSG00000119535 HGNC IDHGNC:HGNC:2439 PHARMGKB IDPA26942 Map Location1p34.3

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DRUGGABLE GENOME

GO terms in CSF3R

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004896	cytokine receptor activity
MF	IEA	GO:0004896	cytokine receptor activity
MF	IBA	GO:0004912	interleukin-3 receptor activity
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0019955	cytokine binding
MF	IBA	GO:0019978	interleukin-3 binding

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Gene expression in normal tissue: CSF3R

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CSF3R

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-168256	Immune System
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-449836	Other interleukin signaling
wikipathways	WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways	WP4172	PI3K-Akt Signaling Pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD870	BRD63610	2
iGMDRD574	Ruxolitinib	2
iGMDRD231	Importazole	3
iGMDRD150	RITA	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CSF3R

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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