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ERCC3

Summary: This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameERCC excision repair 3, TFIIH core complex helicase subunit OMIM IDMIM:133510 Ensembl IDEnsembl:ENSG00000163161 HGNC IDHGNC:HGNC:3435 PHARMGKB IDPA27849 Map Location2q14.3

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX KINASE TUMOR SUPPRESSOR SERINE THREONINE KINASE DNA REPAIR TRANSCRIPTION FACTOR BINDING CLINICALLY ACTIONABLE

GO terms in ERCC3

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IBA	GO:0000112	nucleotide-excision repair factor 3 complex
CC	IBA	GO:0000439	core TFIIH complex
CC	IEA	GO:0000439	core TFIIH complex
CC	TAS	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm

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Gene expression in normal tissue: ERCC3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ERCC3

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Database	Pathway ID	Pathway Des.
wikipathways	WP405	Eukaryotic Transcription Initiation
kegg	hsa03022	Basal transcription factors - Homo sapiens (human)
kegg	hsa03420	Nucleotide excision repair - Homo sapiens (human)
netpath	Pathway_AndrogenReceptor	AndrogenReceptor
reactome	R-HSA-112382	Formation of RNA Pol II elongation complex
reactome	R-HSA-113418	Formation of the Early Elongation Complex

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD297	Austocystin D	2
iGMDRD1008	SR-II-138A	3
iGMDRD599	Salermide	1
iGMDRD126	Tipifarnib	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ERCC3

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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