ERCC3
Summary: This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ERCC excision repair 3, TFIIH core complex helicase subunit | MIM:133510 | Ensembl:ENSG00000163161 | HGNC:HGNC:3435 | PA27849 | 2q14.3 |
GO terms in ERCC3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000112 | nucleotide-excision repair factor 3 complex |
| CC | IBA | GO:0000439 | core TFIIH complex |
| CC | IEA | GO:0000439 | core TFIIH complex |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005669 | transcription factor TFIID complex |
| CC | IBA | GO:0005675 | holo TFIIH complex |
| CC | IDA | GO:0005675 | holo TFIIH complex |
| CC | TAS | GO:0005675 | holo TFIIH complex |
| CC | IBA | GO:0097550 | transcriptional preinitiation complex |
| BP | IBA | GO:0000019 | regulation of mitotic recombination |
| BP | IBA | GO:0000717 | nucleotide-excision repair, DNA duplex unwinding |
| BP | IMP | GO:0000717 | nucleotide-excision repair, DNA duplex unwinding |
| BP | IBA | GO:0001111 | promoter clearance from RNA polymerase II promoter |
| BP | IBA | GO:0001113 | transcriptional open complex formation at RNA polymerase II promoter |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IMP | GO:0006265 | DNA topological change |
| BP | IMP | GO:0006281 | DNA repair |
| BP | IBA | GO:0006283 | transcription-coupled nucleotide-excision repair |
| BP | IDA | GO:0006283 | transcription-coupled nucleotide-excision repair |
| BP | TAS | GO:0006283 | transcription-coupled nucleotide-excision repair |
| BP | IMP | GO:0006289 | nucleotide-excision repair |
| BP | TAS | GO:0006293 | nucleotide-excision repair, preincision complex stabilization |
| BP | TAS | GO:0006294 | nucleotide-excision repair, preincision complex assembly |
| BP | TAS | GO:0006296 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| BP | TAS | GO:0006361 | transcription initiation from RNA polymerase I promoter |
| BP | TAS | GO:0006363 | termination of RNA polymerase I transcription |
| BP | IDA | GO:0006366 | transcription by RNA polymerase II |
| BP | IMP | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0006368 | transcription elongation from RNA polymerase II promoter |
| BP | TAS | GO:0006370 | 7-methylguanosine mRNA capping |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006915 | apoptotic process |
| BP | IMP | GO:0006979 | response to oxidative stress |
| BP | IMP | GO:0008104 | protein localization |
| BP | IBA | GO:0009411 | response to UV |
| BP | IMP | GO:0009411 | response to UV |
| BP | IEA | GO:0009650 | UV protection |
| BP | IBA | GO:0010525 | regulation of transposition, RNA-mediated |
| BP | IEA | GO:0016032 | viral process |
| BP | IBA | GO:0033683 | nucleotide-excision repair, DNA incision |
| BP | IMP | GO:0033683 | nucleotide-excision repair, DNA incision |
| BP | TAS | GO:0033683 | nucleotide-excision repair, DNA incision |
| BP | IBA | GO:0035315 | hair cell differentiation |
| BP | IMP | GO:0035315 | hair cell differentiation |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0048568 | embryonic organ development |
| BP | IEA | GO:0048568 | embryonic organ development |
| BP | IBA | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain |
| BP | TAS | GO:0070911 | global genome nucleotide-excision repair |
| BP | IBA | GO:1901990 | regulation of mitotic cell cycle phase transition |
| BP | IMP | GO:1901990 | regulation of mitotic cell cycle phase transition |
| BP | IBA | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | NAS | GO:0003684 | damaged DNA binding |
| MF | IBA | GO:0004003 | ATP-dependent DNA helicase activity |
| MF | IEA | GO:0004003 | ATP-dependent DNA helicase activity |
| MF | TAS | GO:0004386 | helicase activity |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0008022 | protein C-terminus binding |
| MF | IDA | GO:0008094 | DNA-dependent ATPase activity |
| MF | IMP | GO:0008094 | DNA-dependent ATPase activity |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity |
| MF | IDA | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity |
| MF | IBA | GO:0015616 | DNA translocase activity |
| MF | IDA | GO:0016887 | ATPase activity |
| MF | IBA | GO:0043138 | 3'-5' DNA helicase activity |
| MF | IDA | GO:0043138 | 3'-5' DNA helicase activity |
| MF | IMP | GO:0043138 | 3'-5' DNA helicase activity |
| MF | IPI | GO:0047485 | protein N-terminus binding |
Gene expression in normal tissue: ERCC3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ERCC3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP405 | Eukaryotic Transcription Initiation |
| kegg | hsa03022 | Basal transcription factors - Homo sapiens (human) |
| kegg | hsa03420 | Nucleotide excision repair - Homo sapiens (human) |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| reactome | R-HSA-112382 | Formation of RNA Pol II elongation complex |
| reactome | R-HSA-113418 | Formation of the Early Elongation Complex |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat |
| reactome | R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex |
| reactome | R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| reactome | R-HSA-167161 | HIV Transcription Initiation |
| reactome | R-HSA-167162 | RNA Polymerase II HIV Promoter Escape |
| reactome | R-HSA-167169 | HIV Transcription Elongation |
| reactome | R-HSA-167172 | Transcription of the HIV genome |
| reactome | R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| reactome | R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-427413 | NoRC negatively regulates rRNA expression |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5696395 | Formation of Incision Complex in GG-NER |
| reactome | R-HSA-5696398 | Nucleotide Excision Repair |
| reactome | R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) |
| reactome | R-HSA-5696400 | Dual Incision in GG-NER |
| reactome | R-HSA-674695 | RNA Polymerase II Pre-transcription Events |
| reactome | R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex |
| reactome | R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| reactome | R-HSA-6782135 | Dual incision in TC-NER |
| reactome | R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| reactome | R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes |
| reactome | R-HSA-72086 | mRNA Capping |
| reactome | R-HSA-73762 | RNA Polymerase I Transcription Initiation |
| reactome | R-HSA-73772 | RNA Polymerase I Promoter Escape |
| reactome | R-HSA-73776 | RNA Polymerase II Promoter Escape |
| reactome | R-HSA-73777 | RNA Polymerase I Chain Elongation |
| reactome | R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73863 | RNA Polymerase I Transcription Termination |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75953 | RNA Polymerase II Transcription Initiation |
| reactome | R-HSA-75955 | RNA Polymerase II Transcription Elongation |
| reactome | R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| reactome | R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD239 | Dasatinib | 1 |
| iGMDRD780 | PP-30 | 6 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD369 | TGX-115 | 1 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD700 | AUY922 | 1 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD292 | NSC87877 | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD177 | Teniposide | 6 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD232 | FTI-277 | 1 |
| iGMDRD424 | Tamatinib | 5 |
| iGMDRD594 | AZD-8055 | 1 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD733 | SGC0946 | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD503 | CMK | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ERCC3
CLASSFICATION
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