EIF4E
Summary: The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:133440 Ensembl IDEnsembl:ENSG00000151247 HGNC IDHGNC:HGNC:3287 PHARMGKB IDPA27714 Map Location4q23 | |||||
GO terms in EIF4E
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0000339 | RNA cap binding |
| MF | IDA | GO:0000340 | RNA 7-methylguanosine cap binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003743 | translation initiation factor activity |
| MF | ISS | GO:0003743 | translation initiation factor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: EIF4E
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF4E
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | eifpathway | eukaryotic protein translation |
| biocarta | igf1mtorpathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway |
| biocarta | irespathway | internal ribosome entry pathway |
| biocarta | mtorpathway | mtor signaling pathway |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF4E
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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