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iGMDRD381

Canonical SMILES: CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F

InChI: InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)

InChI Key: HMABYWSNWIZPAG-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Rucaparib	CHEMBL2105733 CHEMBL1173055 CHEMBL3833368	9931950	DB12332	Alone	Small Molecule

Drug Class:

Antineoplastic Agents BCRP/ABCG2 Inhibitors BCRP/ABCG2 Substrates Cytochrome P-450 CYP1A2 Inducers Cytochrome P-450 CYP1A2 Inducers (moderate)Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak)Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (weak)Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate)Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak)Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 2-Ring P-glycoprotein/ABCB1 Inhibitors P-glycoprotein/ABCB1 Substrates Poly(ADP-ribose) Polymerase Inhibitors UGT1A1 Inhibitors

Drug Targets:

PARP1 (P09874)PARP2 (Q9UGN5)PARP3 (Q9Y6F1)

Drug Pathways:

Genome integrity

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
6714	SRC	1
672	BRCA1	7
675	BRCA2	2
673	BRAF	1
1977	EIF4E	1
100862685	ERVK-19	1

Gene in drug-gene network: Network Plot

Models in Rucaparib

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.