iGMDRD381
Canonical SMILES: CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F
InChI: InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)
InChI Key: HMABYWSNWIZPAG-UHFFFAOYSA-N
Drug Class:
Antineoplastic AgentsBCRP/ABCG2 InhibitorsBCRP/ABCG2 SubstratesCytochrome P-450 CYP1A2 InducersCytochrome P-450 CYP1A2 Inducers (moderate)Cytochrome P-450 CYP1A2 SubstratesCytochrome P-450 CYP2C19 InhibitorsCytochrome P-450 CYP2C19 Inhibitors (weak)Cytochrome P-450 CYP2C8 InhibitorsCytochrome P-450 CYP2C8 Inhibitors (weak)Cytochrome P-450 CYP2D6 InhibitorsCytochrome P-450 CYP2D6 Inhibitors (moderate)Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A4 InhibitorsCytochrome P-450 CYP3A4 Inhibitors (weak)Cytochrome P-450 Enzyme InducersCytochrome P-450 Enzyme InhibitorsEnzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 2-RingP-glycoprotein/ABCB1 InhibitorsP-glycoprotein/ABCB1 SubstratesPoly(ADP-ribose) Polymerase InhibitorsUGT1A1 InhibitorsDrug Pathways:
Genome integrityDrug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
Gene in drug-gene network: Network Plot
Models in Rucaparib
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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