CSF1R


Summary: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
colony stimulating factor 1 receptorMIM:164770Ensembl:ENSG00000182578HGNC:HGNC:2433PA269365q32

GO terms in CSF1R


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0001934positive regulation of protein phosphorylation
BPTASGO:0006954inflammatory response
BPTASGO:0007165signal transduction
BPISSGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIBAGO:0007275multicellular organism development
BPTASGO:0007275multicellular organism development
BPIEAGO:0007411axon guidance
BPIMPGO:0008283cell proliferation
BPIMPGO:0008284positive regulation of cell proliferation
BPIEAGO:0008285negative regulation of cell proliferation
BPIMPGO:0008360regulation of cell shape
BPIBAGO:0009968negative regulation of signal transduction
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPIMPGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0021772olfactory bulb development
BPIEAGO:0021879forebrain neuron differentiation
BPIMPGO:0030097hemopoiesis
BPIBAGO:0030154cell differentiation
BPTASGO:0030224monocyte differentiation
BPTASGO:0030225macrophage differentiation
BPISSGO:0030316osteoclast differentiation
BPISSGO:0030335positive regulation of cell migration
BPISSGO:0031529ruffle organization
BPIBAGO:0033674positive regulation of kinase activity
BPIBAGO:0036006cellular response to macrophage colony-stimulating factor stimulus
BPIMPGO:0036006cellular response to macrophage colony-stimulating factor stimulus
BPISSGO:0038145macrophage colony-stimulating factor signaling pathway
BPISSGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPIBAGO:0043066negative regulation of apoptotic process
BPIEAGO:0043066negative regulation of apoptotic process
BPIBAGO:0043410positive regulation of MAPK cascade
BPIEAGO:0045087innate immune response
BPISSGO:0045124regulation of bone resorption
BPIMPGO:0045217cell-cell junction maintenance
BPISSGO:0046488phosphatidylinositol metabolic process
BPIDAGO:0046777protein autophosphorylation
BPISSGO:0048015phosphatidylinositol-mediated signaling
BPTASGO:0060603mammary gland duct morphogenesis
BPIMPGO:0061098positive regulation of protein tyrosine kinase activity
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPISSGO:0070374positive regulation of ERK1 and ERK2 cascade
BPISSGO:0071345cellular response to cytokine stimulus
BPISSGO:0071902positive regulation of protein serine/threonine kinase activity
BPIMPGO:0090197positive regulation of chemokine secretion
BPIMPGO:2000147positive regulation of cell motility
BPISSGO:2000249regulation of actin cytoskeleton reorganization
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCISSGO:0009986cell surface
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIBAGO:0043235receptor complex
CCIBAGO:1990682CSF1-CSF1R complex
CCISSGO:1990682CSF1-CSF1R complex
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIMPGO:0005011macrophage colony-stimulating factor receptor activity
MFISSGO:0005011macrophage colony-stimulating factor receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0019838growth factor binding
MFIEAGO:0019903protein phosphatase binding
MFIDAGO:0019955cytokine binding
MFISSGO:0019955cytokine binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFISSGO:0042803protein homodimerization activity

Gene expression in normal tissue: CSF1R

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CSF1R


DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449836Other interleukin signaling
biocartaetspathwaymets affect on macrophage differentiation
pidavb3_integrin_pathwayIntegrins in angiogenesis
pidcmyb_pathwayC-MYB transcription factor network
pidptp1bpathwaySignaling events mediated by PTP1B
pidtcptp_pathwaySignaling events mediated by TCPTP
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
wikipathwaysWP2848Differentiation Pathway
wikipathwaysWP3640Imatinib and Chronic Myeloid Leukemia
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD300Tozasertib6
iGMDRD147Prima-13
iGMDRD246NPC263
iGMDRD871BRD63683
iGMDRD872BRD71373
iGMDRD269Purmorphamine1
iGMDRD434BMS-5369243
iGMDRD192CIL563
iGMDRD267Oligomycin A1
iGMDRD103SN-383
iGMDRD123Isoevodiamine3
iGMDRD341Triacsin c6
iGMDRD351GW843682X3
iGMDRD424Tamatinib3
iGMDRD701NVP-AUY9226
iGMDRD512nutlin 33
iGMDRD690PRIMA-1MET3
iGMDRD60Quinoclamine6
iGMDRD23Gossypol6
iGMDRD41Imatinib2
iGMDRD451Serdemetan3
iGMDRD188Piperlongumine6
iGMDRD577BIX012942
iGMDRD398Sepantronium3
iGMDRD562Navitoclax2
iGMDRD318PAC-13
iGMDRD513BML-2591
iGMDRD474Avrainvillamide6
iGMDRD61Kinetin riboside6
iGMDRD144NSC953973
iGMDRD781Sirolimus9
iGMDRD889Compound 7d-cis3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CSF1R

​​​​