PRKCH


Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:605437
PHARMGKB IDPA33767
Map Location14q23.1

GO terms in PRKCH


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IMP GO:0006468 protein phosphorylation
BP TAS GO:0007165 signal transduction
BP ISS GO:0010744 positive regulation of macrophage derived foam cell differentiation
BP IBA GO:0018105 peptidyl-serine phosphorylation
BP TAS GO:0030168 platelet activation
BP IMP GO:0034351 negative regulation of glial cell apoptotic process
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Gene expression in normal tissue: PRKCH

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKCH


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-114508 Effects of PIP2 hydrolysis
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-372790 Signaling by GPCR
reactome R-HSA-372790 Signaling by GPCR
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD351 GW843682X 3
iGMDRD61 Kinetin riboside 1
iGMDRD470 Trametinib 1
iGMDRD679 Bistramide A 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKCH

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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