PRKCH
Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:605437 Ensembl IDEnsembl:ENSG00000027075 HGNC IDHGNC:HGNC:9403 PHARMGKB IDPA33767 Map Location14q23.1 |
GO terms in PRKCH
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IMP | GO:0006468 | protein phosphorylation |
BP | TAS | GO:0007165 | signal transduction |
BP | ISS | GO:0010744 | positive regulation of macrophage derived foam cell differentiation |
BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
BP | TAS | GO:0030168 | platelet activation |
BP | IMP | GO:0034351 | negative regulation of glial cell apoptotic process |
Gene expression in normal tissue: PRKCH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKCH
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-109582 | Hemostasis |
reactome | R-HSA-114508 | Effects of PIP2 hydrolysis |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-372790 | Signaling by GPCR |
reactome | R-HSA-372790 | Signaling by GPCR |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PRKCH
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |