PRKCH
Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase C eta | MIM:605437 | Ensembl:ENSG00000027075 | HGNC:HGNC:9403 | PA33767 | 14q23.1 |
GO terms in PRKCH
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | ISS | GO:0010744 | positive regulation of macrophage derived foam cell differentiation |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IMP | GO:0034351 | negative regulation of glial cell apoptotic process |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0045618 | positive regulation of keratinocyte differentiation |
| BP | IMP | GO:0050861 | positive regulation of B cell receptor signaling pathway |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0060252 | positive regulation of glial cell proliferation |
| BP | IEA | GO:0070528 | protein kinase C signaling |
| BP | TAS | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | IMP | GO:2000810 | regulation of bicellular tight junction assembly |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004697 | protein kinase C activity |
| MF | IEA | GO:0004699 | calcium-independent protein kinase C activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0017160 | Ral GTPase binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: PRKCH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKCH
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114508 | Effects of PIP2 hydrolysis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-418597 | G alpha (z) signalling events |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| pid | endothelinpathway | Endothelins |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD351 | GW843682X | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD470 | Trametinib | 1 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD546 | BMS-754807 | 4 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD41 | Imatinib | 1 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD471 | Trametinib (plus imatinib in BCR-ABL) | 1 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD267 | Oligomycin A | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKCH
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