Summary: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008].

Raf-1 proto-oncogene, serine/threonine kinaseMIM:164760Ensembl:ENSG00000132155HGNC:HGNC:9829PA341833p25.2

GO terms in RAF1

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005741mitochondrial outer membrane
CCIPIGO:0005794Golgi apparatus
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0016607nuclear speck
BPIBAGO:0000165MAPK cascade
BPTASGO:0000165MAPK cascade
BPIDAGO:0000186activation of MAPKK activity
BPIEAGO:0001666response to hypoxia
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPTASGO:0006468protein phosphorylation
BPTASGO:0006915apoptotic process
BPTASGO:0007165signal transduction
BPIDAGO:0007190activation of adenylate cyclase activity
BPIEAGO:0007507heart development
BPTASGO:0008283cell proliferation
BPIDAGO:0008285negative regulation of cell proliferation
BPIEAGO:0030154cell differentiation
BPTASGO:0030168platelet activation
BPIEAGO:0030878thyroid gland development
BPIDAGO:0031333negative regulation of protein complex assembly
BPIDAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPTASGO:0034220ion transmembrane transport
BPIEAGO:0035019somatic stem cell population maintenance
BPTASGO:0035023regulation of Rho protein signal transduction
BPIEAGO:0035773insulin secretion involved in cellular response to glucose stimulus
BPIEAGO:0035994response to muscle stretch
BPTASGO:0042060wound healing
BPTASGO:0042981regulation of apoptotic process
BPIDAGO:0043066negative regulation of apoptotic process
BPTASGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEAGO:0045104intermediate filament cytoskeleton organization
BPTASGO:0045595regulation of cell differentiation
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048011neurotrophin TRK receptor signaling pathway
BPIEAGO:0048538thymus development
BPIEAGO:0060324face development
BPIEAGO:0071550death-inducing signaling complex assembly
BPIEAGO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPTASGO:2000145regulation of cell motility
MFTASGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0008179adenylate cyclase binding
MFIEAGO:0010856adenylate cyclase activator activity
MFTASGO:0016301kinase activity
MFIPIGO:0019899enzyme binding
MFIPIGO:0031267small GTPase binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0046872metal ion binding
MFIEAGO:0046982protein heterodimerization activity

Gene expression in normal tissue: RAF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAF1

DatabasePathway IDPathway Des.
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
biocartaat1rpathwayangiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocartabarrestinsrcpathwayroles of arrestin dependent recruitment of src kinases in gpcr signaling
biocartabarrmapkpathwayrole of -arrestins in the activation and targeting of map kinases
biocartabcrpathwaybcr signaling pathway
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartaccr3pathwayccr3 signaling in eosinophils
biocartacdk5pathwayphosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway
biocartacdmacpathwaycadmium induces dna synthesis and proliferation in macrophages
biocartaceramidepathwayceramide signaling pathway
biocartaedg1pathwayphospholipids as signalling intermediaries
biocartaerk5pathwayrole of erk5 in neuronal survival pathway
biocartaerkpathwayerk1/erk2 mapk signaling pathway
biocartafcer1pathwayfc epsilon receptor i signaling in mast cells
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
biocartagleevecpathwayinhibition of cellular proliferation by gleevec
biocartagpcrpathwaysignaling pathway from g-protein families
biocartahbxpathwaycalcium signaling by hbx of hepatitis b virus
biocartaher2pathwayrole of erbb2 in signal transduction and oncology
biocartaigf1pathwayigf-1 signaling pathway
biocartaigf1rpathwaymultiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamalpathwayrole of mal in rho-mediated activation of srf
biocartamapkpathwaymapkinase signaling pathway
biocartamelanocytepathwaymelanocyte development and pigmentation pathway
biocartangfpathwaynerve growth factor pathway (ngf)
biocartapdgfpathwaypdgf signaling pathway
biocartapyk2pathwaylinks between pyk2 and map kinases
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartaraspathwayras signaling pathway
biocartasam68pathwayregulation of splicing through sam68
biocartasppapathwayaspirin blocks signaling pathway involved in platelet activation
biocartasprypathwaysprouty regulation of tyrosine kinase signals
biocartatcrpathwayt cell receptor signaling pathway
biocartatffpathwaytrefoil factors initiate mucosal healing
biocartatpopathwaytpo signaling pathway
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-2672351Stimuli-sensing channels
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-392517Rap1 signalling
reactomeR-HSA-430116GP1b-IX-V activation signalling
reactomeR-HSA-438064Post NMDA receptor activation events
reactomeR-HSA-442742CREB phosphorylation through the activation of Ras
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5621575CD209 (DC-SIGN) signaling
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673000RAF activation
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5674135MAP2K and MAPK activation
reactomeR-HSA-5674499Negative feedback regulation of MAPK pathway
reactomeR-HSA-5675221Negative regulation of MAPK pathway
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6802946Signaling by moderate kinase activity BRAF mutants
reactomeR-HSA-6802948Signaling by high-kinase activity BRAF mutants
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAF
reactomeR-HSA-6802957Oncogenic MAPK signaling
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-983712Ion channel transport
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
smpdbSMP00391Insulin Signalling
wikipathwaysWP127IL-5 Signaling Pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP1993Angiogenesis overview
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2035Follicle Stimulating Hormone (FSH) signaling pathway
wikipathwaysWP2036TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2197Endothelin Pathways
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP2512Integrated Lung Cancer Pathway
wikipathwaysWP2586Aryl Hydrocarbon Receptor
wikipathwaysWP2636Common Pathways Underlying Drug Addiction
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP2870Extracellular vesicle-mediated signaling in recipient cells
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP313Signaling of Hepatocyte Growth Factor Receptor
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3680Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3849MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ
wikipathwaysWP3853ERK Pathway in Huntington,s Disease
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP38794-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP422MAPK Cascade
wikipathwaysWP4223Ras Signaling
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP49IL-2 Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP581EPO Receptor Signaling
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP732Serotonin Receptor 2 and ELK-SRF-GATA4 signaling
pidar_nongenomic_pathwayNongenotropic Androgen signaling
pidbcr_5pathwayBCR signaling pathway
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidcdc42_pathwayCDC42 signaling events
pidceramide_pathwayCeramide signaling pathway
pidcxcr3pathwayCXCR3-mediated signaling events
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb1_internalization_pathwayInternalization of ErbB1
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
pidfak_pathwaySignaling events mediated by focal adhesion kinase
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidgmcsf_pathwayGMCSF-mediated signaling events
pidigf1_pathwayIGF1 pathway
pidil2_1pathwayIL2-mediated signaling events
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidmapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidmtor_4pathwaymTOR signaling pathway
pidp38_mk2pathwayp38 signaling mediated by MAPKAP kinases
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidpi3kciaktpathwayClass I PI3K signaling events mediated by Akt
pidrb_1pathwayRegulation of retinoblastoma protein
pidshp2_pathwaySHP2 signaling
pidtcrraspathwayRas signaling in the CD4+ TCR pathway
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165959584Sorafenib Pharmacodynamics
pharmgkbPA165980050Vemurafenib Pathway, Pharmacodynamics
pharmgkbPA165980050update your name in edit mode
pharmgkbPA2032VEGF Signaling Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD95Isonicotinohydroxamic acid1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAF1