PECAM1

Summary: The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameplatelet and endothelial cell adhesion molecule 1
OMIM IDMIM:173445
Ensembl IDEnsembl:ENSG00000261371
HGNC IDHGNC:HGNC:8823
PHARMGKB IDPA33167
Map Location17q23.3

GO terms in PECAM1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IDA GO:0042803 protein homodimerization activity
CC IDA GO:0005615 extracellular space
CC IDA GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
CC IEA GO:0016021 integral component of membrane
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Gene expression in normal tissue: PECAM1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PECAM1


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Database
Pathway ID
Pathway Des.
biocarta cell2cellpathway cell to cell adhesion signaling
reactome R-HSA-109582 Hemostasis
reactome R-HSA-114608 Platelet degranulation
reactome R-HSA-1474244 Extracellular matrix organization
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD798 Ceranib-2 1
iGMDRD87 Epigallocatechin-3-monogallate 2
iGMDRD401 Afatinib 1
iGMDRD394 BX-795 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PECAM1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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