iGMDRD395

Canonical SMILES: CC1=CC=CC(=N1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N

InChI: InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)

InChI Key: IVRXNBXKWIJUQB-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameLY2157299
CHEMBLCHEMBL2364611
Pubchem CID10090500
DRUGBANK IDDB11911
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Drug-gene pathway enrichments

2reactome: Interleukin-12 family signaling2reactome: Interferon gamma signaling2reactome: Interleukin-6 signaling2reactome: Signaling by Interleukins2reactome: Interleukin-3, Interleukin-5 and GM-CSF signaling2reactome: Interleukin-6 family signaling2reactome: Interferon Signaling2reactome: Immune System2reactome: Regulation of IFNG signaling2reactome: Interleukin-12 signaling

Drug-gene GO enrichments

4BP: cytokine-mediated signaling pathway4MF: protein tyrosine kinase activity2MF: histone kinase activity (H3-Y41 specific)2MF: growth hormone receptor binding2BP: histone H3-Y41 phosphorylation2BP: JAK-STAT cascade involved in growth hormone signaling pathway2BP: interleukin-12-mediated signaling pathway2BP: erythrocyte differentiation2BP: tyrosine phosphorylation of STAT protein2CC: nucleoplasm

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3717 JAK2 1
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Gene in drug-gene network: Network Plot

MST-312MST-312cytochalasin.Bcytochalasin.Btriacsin Ctriacsin CBRD6368BRD6368ruxolitinib (in SH2B3 deleted)ruxolitinib (in SH2B3 deleted)nakiterpiosinnakiterpiosinNsc 632839Nsc 632839pluripotinpluripotinSirolimusSirolimusJAK2JAK2LY2157299LY2157299

Models in LY2157299

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(ERALPHA_pS118) protein MCLP LUNG undefined LY.2157299 sensitivity in vitro
EXP(JAK2) protein MCLP undefined PANCAN LY.2157299 sensitivity in vitro
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