iGMDRD821

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Standard Name
Drug Status
Standard NameTAK-788
Drug StatusAlone

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 6

Drug-gene pathway enrichments

4reactome: Signal Transduction4reactome: SHC1 events in ERBB2 signaling4reactome: Signaling by ERBB24reactome: Signaling by Receptor Tyrosine Kinases3reactome: GRB2 events in ERBB2 signaling2reactome: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors2reactome: Downregulation of ERBB2 signaling2reactome: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors2reactome: Signaling by Non-Receptor Tyrosine Kinases2reactome: Intracellular signaling by second messengers

Drug-gene GO enrichments

9MF: protein tyrosine kinase activity5CC: receptor complex5CC: plasma membrane4MF: transmembrane receptor protein tyrosine kinase activity4MF: transmembrane signaling receptor activity4MF: epidermal growth factor-activated receptor activity4BP: positive regulation of ERK1 and ERK2 cascade3MF: MAP kinase kinase kinase activity3BP: negative regulation of apoptotic process3BP: positive regulation of protein kinase B signaling

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2064 ERBB2 2
1956 EGFR 4
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Models in TAK-788

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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